Microdeletions within the hydrophobic core region of cellular prion protein alter its topology and metabolism

Biochemical and Biophysical Research Communications

Volumn 393, Issue 3, 2010, Pages 439-444

  Lutz, Jens ^a,d   Brabeck, Christine ^a   Niemann, Hartmut H ^b   Kloz, Ulrich ^c   Korth, Carsten ^d   Lingappa, Vishwanath R ^e   Bürkle, Alexander ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

Cleavage; C1 fragment; Membrane topology; Prion protein; Transmembrane domain

Indexed keywords

POLYPEPTIDE; PRION PROTEIN; PROTEINASE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HYDROPHOBICITY; MEMBRANE POTENTIAL; MEMBRANE STRUCTURE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN METABOLISM;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; HYDROPHOBICITY; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; SEQUENCE DELETION;

EID: 77949264271     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.015     Document Type: Article

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