The inhibitor of IkappaBalpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices

Neuroscience Letters

Volumn 377, Issue 3, 2005, Pages 147-151

  Goffi, F ^a   Boroni, F ^a   Benarese, M ^a   Sarnico, I ^a   Benetti, A ^b   Spano, P F ^a   Pizzi, M ^a  

^a Division of Pharmacology   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

BAY 11 7082; Neuroprotection; NF B; NMDA

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; GLUTAMIC ACID; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N METHYL DEXTRO ASPARTIC ACID; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; I KAPPA B; N METHYLASPARTIC ACID; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NITRILE; SULFONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITOTOXICITY; GEL MOBILITY SHIFT ASSAY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; HIPPOCAMPUS; I-KAPPA B PROTEINS; MICE; N-METHYLASPARTATE; NITRILES; PHOSPHORYLATION; SULFONES;

EID: 14744287457     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.11.088     Document Type: Article

References (34)

1. J.R. Bethea, M. Castro, R.W. Keane, T.T. Lee, W.D. Dietrich, and R.P. Yezierski Traumatic spinal cord injury induces nuclear factor-kappaB activation J. Neurosci. 18 1998 3251 3260
2. P.J. Brooks, C. Marietta, and D. Goldman DNA mismatch repair and DNA methylation in adult brain neurons J. Neurosci. 16 1996 939 945
3. Z. Chen, J. Hagler, V.J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Genes Dev. 9 1995 1586 1597
4. J.A. Clemens, D.T. Stephenson, E.B. Smalstig, E.P. Dixon, and S.P. Little Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats Stroke 28 1997 1073 1080
5. E.P. Dixon, D.T. Stephenson, J.A. Clemens, and S.P. Little Bcl-Xshort is elevated following severe global ischemia in rat brains Brain Res. 776 1997 222 229
6. 2+ of N-methyl-d-aspartate and quisqualate neurotoxicity in young rat hippocainpal slices Neurosci. Lett. 97 1989 316 322
7. S. Ghosh, M.J. May, and E.B. Kopp NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses Annu. Rev. Immunol. 16 1998 225 260
8. M. Grilli, and M. Memo Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway Cell Death Differ. 6 1999 22 27
9. M. Grilli, M. Pizzi, M. Memo, and P.F. Spano Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation Science 274 1996 1383 1385
10. L. Guerrini, F. Blasi, and S. Denis-Donini Synaptic activation of NF-κB by glutamate in cerebellar granule neurons in vitro Proc. Natl. Acad. Sci. U.S.A. 92 1995 9077 9081
11. S. Hunot, B. Brugg, D. Ricard, P.P. Michel, M.P. Muriel, M. Ruberg, B.A. Faucheux, Y. Agid, and E.C. Hirsch Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson's disease Proc. Natl. Acad. Sci. U.S.A. 94 1997 7531 7536
12. K.F. Izban, M. Ergin, J.Z. Qin, R.L. Martinez, R.J. Pooley, S. Saeed, and S. Alkan Constitutive expression of NF-kappa B is a characteristic feature of mycosis fungoides: implications for apoptosis resistance and pathogenesis Hum. Pathol. 31 2000 1482 1490
13. B. Kaltschmidt, M. Uherek, H. Wellmann, B. Volk, and C. Kaltschmidt Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis Proc. Natl. Acad. Sci. U.S.A. 96 1999 9409 9414
14. S.A. Keller, E.J. Schattner, and E. Cesarman Inhibition of NF-kappa B induces apoptosis of KSHV-infected primary effusion lymphoma cells Blood 96 2000 2537 2542
15. J.M. Levenson, S. Choi, S.Y. Lee, Y.A. Cao, H.J. Ahn, K.C. Worley, M. Pizzi, H.C. Liou, and J.D. Sweatt A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel J. Neurosci. 24 2004 3933 3943
16. F. Lezoualc'h, S. Engert, B. Berning, and C. Behl Corticotropin-releasing hormone-mediated neuroprotection against oxidative stress is associated with the increased release of non-amyloidogenic amyloid beta precursor protein and with the suppression of nuclear factor-kappaB Mol. Endocrinol. 14 2000 147 159
17. F. Lezoulac'h, Y. Sagara, F. Holsboer, and C. Behl High constitutive NF-κB activity mediates resistance to oxidative stress in neuronal cells J. Neurosci. 18 1998 3224 3232
18. S.A. Lipton Janus faces of NF-kappa B: neurodestruction versus neuroprotection Nat. Med. 3 1997 20 22
19. S.B. Maggirwar, P.D. Sarmiere, S. Dewhurst, and R.S. Freeman Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons J. Neurosci. 18 1998 10356 10365
20. M.P. Mattson, Y. Goodman, H. Luo, W. Fu, and K. Furukawa Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration J. Neurosci. Res. 49 1997 681 697
21. M.K. Meffert, J.M. Chang, B.J. Wiltgen, M.S. Fanselow, and D. Baltimore NF-kappa B functions in synaptic signaling and behavior Nat. Neurosci. 6 2003 1072 1078
22. A. Nurmi, P.J. Lindsberg, M. Koistinaho, W. Zhang, E. Juettler, M.L. Karjalainen-Lindsberg, F. Weih, N. Frank, M. Schwaninger, and J. Koistinaho Nuclear factor-kappaB contributes to infarction after permanent focal ischemia Stroke 35 2004 987 991
23. L.A. O'Neill, and C. Kaltschmidt NF-kappa B: a crucial transcription factor for glial and neuronal cell function Trends Neurosci. 20 1997 252 258
24. J.W. Pierce, R. Schoenleber, G. Jesmok, J. Best, S.A. Moore, T. Collins, and M.E. Gerritsen Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo J. Biol. Chem. 272 1997 21096 21103
25. M. Pizzi, O. Consolandi, M. Memo, and P.F. Spano N-Methyl-d-aspartate neurotoxicity in hippocampal slices; protection by aniracetam Eur. J. Pharmacol. 275 1995 311 314
26. M. Pizzi, F. Goffi, F. Boroni, M. Benarese, S.E. Perkins, H.C. Liou, and P. Spano Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta J. Biol. Chem. 277 2002 20717 20723
27. Z.H. Qin, R.W. Chen, Y. Wang, M. Nakay, C. DeMaw, and T.N. Chase Nuclear factor κB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum J. Neurosci. 19 1999 4023 4035
28. M.M. Remacle-Bonnet, F.L. Garrouste, S. Heller, F. Andre, J.L. Marvaldi, and G.J. Pommier Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappa B signaling pathways Cancer Res. 60 2000 2007 2017
29. A. Schneider, A. Martin-Villalba, F. Weih, J. Vogel, T. Wirth, and M. Schwaninger NF-kappaB is activated and promotes cell death in focal cerebral ischemia Nat. Med. 5 1999 554 559
30. M.N. Schölzke, I. Potrovita, S. Subramaniam, S. Prinz, and M. Schwaninger Glutamate activates NF-kappaB through calpain in neurons Eur. J. Neurosci. 18 2003 3305 3310
31. K. Terai, A. Matsuo, and P.L. McGeer Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease Brain Res. 735 1996 159 168
32. M. Woods, E.G. Wood, J.A. Mitchell, and T.D. Warner Signal transduction pathways involved in cytokine stimulation of endothelin-1 release from human vascular smooth muscle cells J. Cardiovasc. Pharmacol. 36 2000 S407 S409
33. T. Yabe, D. Wilson, and J.P. Schwartz NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons J. Biol. Chem. 276 2001 43313 43319
34. M.J. Yin, Y. Yamamoto, and R.B. Gaynor The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta Nature 396 1998 77 80