CagA status and VacA subtypes of Helicobacter pylori in relation to histopathologic findings in Iranian population

Indian Journal of Pathology and Microbiology

Volumn 53, Issue 1, 2010, Pages 24-27

  Molaei, Mahsa ^a   Foroughi, Forough ^a   Mashayekhi, Reza ^a   Haghazali, Mehrdad ^a   Zojaji, Homayoon ^a   Jafari, Fereshteh ^a   Dabiri, Hossein ^a   Zali, Mohammad Reza ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

CagA status; Helicobecter pylori; VacA subtypes

Indexed keywords

BACTERIAL DNA; CAGA PROTEIN; VACUOLATING TOXIN;

ADULT; AGED; ALLELE; ARTICLE; BACTERIAL STRAIN; CHRONIC GASTRITIS; CLINICAL FEATURE; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA ISOLATION; DYSPEPSIA; FEMALE; GENE IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTESTINE METAPLASIA; IRAN; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; POLYMERASE CHAIN REACTION; POPULATION; POPULATION DENSITY; PROTEIN ANALYSIS; SCORING SYSTEM; STOMACH BIOPSY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOPSY; CROSS-SECTIONAL STUDIES; DNA, BACTERIAL; FEMALE; GASTRITIS; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HISTOCYTOCHEMISTRY; HUMANS; IRAN; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 77749309682     PISSN: 03774929     EISSN: 09745130     Source Type: Journal    
DOI: 10.4103/0377-4929.59178     Document Type: Article

References (27)

1. Malekzadeh R, Sotoudeh M, Derakhshan MH, Mikaeli J, Yazdanbod A, Merat S, et al. Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the North-West of Iran. J Clin Pathol 2004;57:37-42.
2. Blaser MJ. Intrastrain differences in Helicobacter pylori: a key question in mocosal damage. Ann Med 1995;27:559-63.
3. Atherton JC. H. pylori virulence factors. Br Med Bull 1998;54:105-20.
4. Xiang Z, Censini S, Bayeli P F, Telford JL, Figura N, Rappuoli R, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995;63:94-8.
5. Blaser MJ. Role of vacA and the cagA locus of Helicobacter pylori in human disease. Aliment Pharmacol Ther 1996;10:73-7.
6. Rudi J, Kolb C, Maiwald M, Kuck D, Sieg A, Galle PR, et al. Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases. J Clin Microbiol 1998;36:944-8.
7. Zhou W, Yamazaki S, Yamakawa A, Ohtani M, Ito Y, Keida Y, et al. The diversity of vacA and cagA genes of Helicobacter pylori in East Asia. FEMS Immunol Med Microbiol 2004;40:81-7.
8. Backert S, Schwarz T, Miehlke S, Kirsch C, Sommer C, Kwok T, et al. Functional analysis of the cag, pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer. Infect Immun 2004;72:1043-56.
9. Hatakeyama M, Higashi H. Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis. Cancer Sci 2005;96:835-43.
10. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-5.
11. Martin AC, Penn C W. H. pylori. In: Sussman M, ed. Molecular and medical microbiology. San Diego: Academic Press; 2002. p. 1331.
12. Evans DG, Queiroz DM, Mendes EN, Evans DJ Jr. Helicobacter pylori cagA status and s and m alleles of vacA in isolates from individuals with a variety of H. pylori associated gastric diseases. J Clin Microbiol 1998;36:3435-7.
13. Maeda S, Ogura K, Yoshida H, Kanai F, Ikenoue T, Kato N, et al. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut 1998;42:338-43.
14. Rudi J, Kuck D, Rudy A, Sieg A, Maiwald M, Stremmel W. Helicobacter pylori vacA genotypes and cagA gene in a series of 383 H. pylori positive patients. Z Gastroenterol 2000;38:559-64.
15. Dixon M F, Genta RM, Yardley JH, Correa P. Classification and Grading of Gastritis: The Updated Sydney System. Am J Surg Pathol 1996;20:1161-81.
16. Cover TL, Tummuru MK, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 1994;269:10566-73.
17. Kidd M, Lastovica AJ, Atherton JC, Louw JA. Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa. Gut 1999;45:499-502.
18. Morales-Espinosa R, Castillo-Rojas G, Gonzalez-Valencia G, Ponce de León S, Cravioto A, Atherton JC, et al. Colonization of Mexican patients by multiple Helicobacter pylori strains with different vacA and cagA genotypes. J Clin Microbiol 1999;37:3001-4.
19. Weel J F, van der Hulst RW, Gerrits Y, Roorda P, Feller M, Dankert J, et al. The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin and Helicobacter pylori-related diseases. J Infect Dis 1996;173:1171-5.
20. Chen XJ, Yan J, Shen Y F. Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases. Chin Med J (Engl) 2005;118:460-6.
21. Erzin Y, Koksal V, Altun S, Dobrucali A, Aslan M, Erdamar S, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 Genotypes and Correlation with Clinical Outcome in Turkish Patients with Dyspepsia. Helicobacter 2006;11:574-80.
22. Siavoshi F, Malekzadeh R, Daneshmand M, Ashktorab H. Helicobacter pylori endemic and gastric disease. Dig Dis Sci 2005;50:2075-80.
23. Martins LC, Corvelo TC, Demachki S, Araujo MT, Assumpção MB, Vilar SC, et al. Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazil. Mem Inst Oswaldo Cruz 2005;100:875-81.
24. Nogueira C, Figueiredo C, Carneiro F, Gomes AT, Barreira R, Figueira P, et al. Helicobacter pylori genotypes may determine gastric histopathology. Am J Pathol 2001;158:647-54.
25. Aydin F, Kaklikkaya N, Ozgur O, Cubukcu K, Kilic AO, Tosun I, et al. Distribution of vacA alleles and cagA status of Helicobacter pylori in peptic ulcer disease and non-ulcer dyspepsia. Clin Microbiol Infect 2004;10:1102-4.
26. van Doorn LJ, Figueiredo C, Rossau R, Jannes G, van Asbroek M, Sousa JC, et al. Typing of Helicobacter pylori vacA gene by PCR and reverse hybridization. J Clin Microbiol 1998;36:1271-6.
27. Warburton VJ, Everett S, Mapstone N P, Axon AT, Hawkey P, Dixon M F. Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. J Clin Pathol 1998;51:55-61.