Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazil

Memorias do Instituto Oswaldo Cruz

Volumn 100, Issue 8, 2005, Pages 875-881

  Martins, Luisa Caricio ^a   De Corvelo Oliveira, Tereza Cristina ^a   Demachki, Samia ^b   Araujo, Marialva T F ^b   Assumpção, Mônica Baraúna ^c   Vilar, Simone Cristina Araujo Jucá ^d,e   Freitas, Felipe Bonfim ^a   Barbosa, Hivana Patricia Melo ^a   Fecury, Amanda Alves ^a   Amaral, Renata Kelly Costa Do ^a   Santos, Sidney Emanuel Batista Dos ^f  

^a Campus Universitário do Guamá   (Brazil)

^b Departamento de Patologia   (Brazil)

^c Hospital Universitário João de Barros Barreto Belém   (Brazil)

^d Hospital Ofir Loiola   (Brazil)

^e Departamento de Endoscopia   (Brazil)

^f FEDERAL UNIVERSITY OF PARÁ   (Brazil)

Author keywords

Brazil; CagA status; Helicobacter pylori; Peptic ulcer; Vaca alleles

Indexed keywords

HELICOBACTER PYLORI;

EID: 32244444685     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762005000800009     Document Type: Article

References (40)

1. Aguiar FCD, Corvelo OCT, Araújo M, Cruz ME, Daibes S, Assumpção BM 2002. Expression of ABU e Lewis antigens in chronic gastritis and preneoplasic alterations in gastric mucosa. Arq Gustroenterol 39: 222-232.
2. Ashour AA, Magalhães PP, Mendes EN, Collares GB, de Gusmão VR, Queiroz DM, Nogueira AM, Rocha GA, de Oliveira CA 2002. Genotypes of vacA strains of Helicobacter pylori isolated from Brazilian adult with gatritis, duodenal ulcer or gastric carcinoma. FEMS Immunol Med Microbiol 1412: 1-6.
3. Atherton JC, Coo P, Peek Jr RM, Tummuru MK, Blaser MJ, Clover TL 1995. Mosaicism in vacuolations alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270: 17771-17777.
4. Atherton JC, Peek RM, Tham KT, Cover TL, Blaser MJ 1997. Clinical and pathological importance of heterogeneity in vacA the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112: 92-99.
5. Ayres M, Ayres MJ, Ayres DL, Santos AS 2003. Bioestat 3.0 Aplicações Estatísticas nas Áreas das Ciências Biológicas e Médicas, 3rd ed., Sociedade Civil Mamirauá, MCT CNPq, Belém, 291 pp.
6. Backert S, Schwarz T, Miehlke S, Kirsch C, Sommer C, Kwok T, Gerhard M, Goebel UB, Lehn N, Koenig W, Meyer TF 2004. Functional analysis of the cag, pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer. Infect Immun 72: 1043-1056.
7. Brito CAA, Silva LMB, Jucá N, Nilma C, Leal CN, Souzo W, Queiroz D, Cordeiro F, Silva NL 2000. Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori associated gastroduodenal diseases in Recife, Pernambuco, Brazil. Mem Inst Oswaldo Cruz 98: 817-821.
8. Catalano M, Matteo M, Barbolla RE, Vega DEJ, Crespo O, Leanza AG, Toppor J, Antelo P 2001. Helicobacter pylori vacA genotypes, cagA status and ureA B polymorphism isolates recovered from an Argentine population. Diagn Microbiol Infect Dis 41: 205-210.
9. Cover TL, Blaser MJ 1992. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem 267: 10570-10575.
10. Cover TL, Krishna US, Israel DA, Peek RMJR 2003. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res 63: 951-957.
11. Dixon MF, Genta RM, Yardley JH, Correa P 1997. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? The International Workshop on the Histopathology of Gastritis. Helicobacter (Suppl. 1): S17-24.
12. Dunn BE, Cohen H, Blaser MJ 1997. Helicobacter pylori. Clin Microbiol Rev 10: 720-741.
13. Evans DG, Queiroz DM, Mendes EN, Evans Jr DJ 1998. Helicobacter pylori cagA status and s and m alleles of vacA in isolates from individuals with a variety of H. pylori associated gastric diseases. J Clin Microbiol 36: 3435-3437.
14. Forsyth MH, Atherton JC, Blaser MJ, Cover TL 1998. Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. Infect Immun 66: 3088-3094.
15. Gatti LL, Fagundes E, Souza EK, Leite KR, de Souza Bastos EL, Vicentini LR, da Silva LC, Smith MA, Payao SL 2005. cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients. Diagn Microbiol Infect Dis 51: 231-235.
16. Hammar M, Tyszkiewicz T, Wadstrom T, O'Toole PW 1992. Rapid detection of Helicobacter pylori in gastric biopsy material by polymerase chain reaction. J Clin Microbiol 30: 54-58.
17. Hatakeyama M 2003. Helicobacter pylori CagA a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins. Microbes Infect 5: 143-150.
18. Kidd M, Lastovica AJ, Atherton JC, Louw JA 1999. Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa? Gut 45: 499-502.
19. Maeda S, Ogura K, Yoshida H, Kanai F, Ikenoue T, Kato N, Shiratori Y, Omata M 1998. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut 42: 338-343.
20. Mattar R, Laudanna AA 2000. Helicobacter pylori genotyping from positive clotests in patients with duodenal ulcer. Rev Hosp Clín 55: 155-160.
21. Morales-Espinosa R, Castillo-Rojas G, Gonzalez-Valencia G, Ponce de Leon S, Cravioto A, Atherton JC, Lopez-Vidal Y 1999. Colonization of Mexican patients by multiple Helicobacter pylori strains with different vacA and cagA genotypes. J Clin Microbiol 37: 3001-3004.
22. Nogueira C, Figueiredo C, Carneiro F, Gomes AT, Barreira R. Figueira P, Salgado C, Belo L, Peixoto A, Bravo JC, Bravo LE, Realpe JL, Plaisier AP, Quint WG, Ruiz B, Correa P, van Doom LJ 2001. Helicobacter pylori genotypes may determine gastric histopathology. Am J Pathol 158: 647-654.
23. Nomura A, Stemmermann GN, Chyou PH, Perez-Perez GI, Blaser MJ 1994. Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann Intern Med 120: 977-981.
24. Pai R, Cover TL, Tarnawski AS 1999. Helicobacter pylori vacuolating cytotoxin disorganizes the cytoskeletal architecture of gastric epithelial cells. Biochem Biophys Res Commun 262: 245-250.
25. Pan ZJ, van der Hulst RW, Feller M, Xiao SD, Tytgat GN, Dankert J, van der Ends A 1997. Equally high prevalences of infection with cagA positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis associated dyspepsia. J Clin Microbiol 35: 1344-1377.
26. Pan ZJ, van der Hulst RW, Tytgat GN, Dankert J, van der Ende A 1999. Relation between vacA subtypes, cytotoxin activity, and disease in Helicobacter pylori infected patients from the Netherlands. Am J Gatroenterol 94: 1517-1521.
27. Papini E, Zoratti M, Cover TL 2001. In search of Helicobacter pylori vacA mechanism of action. Toxicon 39:1757-1767.
28. Ribeiro ML, Godoy AP, Benvengo YH, Mendonca S, Pedrazzoli Jr J 2003. Clinical relevance of the cagA, vacA and iceA genotypes of Helicobacter pylori in Brazilian clinical isolates. FEMS Immunol Med Microbiol 36: 181-185.
29. Rudi J, Kuck D, Rudy A, Sieg A, Maiwald M, Stremmel W 2000. Helicobacter pylori vacA genotypes and cagA gene in a series of 383 H. pylori positive patients. Z Gastroenterol 38: 559-564.
30. Segal ED, Cha J, Lo J, Falkow S, Tompkins LS 1999. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 96: 14559-14564.
31. Stein M, Rappuoli R, Covacci A 2000. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag driven host cell translocation. Proc Natl Acad Sci USA 97: 1263-1268.
32. Taylor DN, Blaser MJ 1991. The epidemiology of Helicobacter pylori infection. Epidemiology 13: 42-59.
33. Tham KT, Peek Jr RM, Atherton JC, Cover TL, Perez-Perez GI, Shyr Y, Blaser MJ 2001. Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease. Hum Pathol 32: 264-273.
34. Tummuru MK, Cover TL, Blaser MJ 1993. Cloning and expression of a high molecular mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 61: 1799-1809.
35. Tummuru MKR, Sharma SA, Blaser MJ 1995. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol 18: 867-876.
36. van Doorn LJ, Figueiredo C, Megraud F, Pena S, Midolo P, Queiroz DM, Carneiro F, Vanderborght B, Pegado MD, Sanna R, De Boer W, Schneeberger PM, Correa P, Ng EK, Atherton J, Blaser MJ, Quint WG 1999. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 116: 823-830.
37. van Doom LJ, Figueiredo C, Sanna R, Plaisier A, Schneeberger P, de Boer W, Quint W 1998. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology 115: 58-66.
38. Willhite CD, Blanke RS 2004. Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity. Cell Microbiol 6: 143-154.
39. Zheng PY, Hua J, Yeoh KG, Ho B 2000. Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population. Gut 47: 18-22.
40. Zhou W, Yamazaki S, Yamakawa A, Ohtani M, Ito Y, Keida Y, Hiashi H, Hatakeyama M, Si J, Azuma T 2004. The diversity of vacA and cagA genes of Helicobacter pylori in East Asia. FEMS Immunol. Med Microbiol 40: 81-87.