Fitting the linear-quadratic model to detailed data sets for different dose ranges

Physics in Medicine and Biology

Volumn 51, Issue 11, 2006, Pages 2813-2823

  Garcia, L M ^a,b   Leblanc, J ^b   Wilkins, D ^b   Raaphorst, G P ^b  

^a CARLETON UNIVERSITY   (Canada)

^b OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPUTER SIMULATION; DATA HANDLING; MATHEMATICAL MODELS; MONTE CARLO METHODS; STATISTICAL METHODS;

GLIOBLASTOMA CELLS; HUMAN PROSTATE CARCINOMA CELL LINES; LQ MODELS; SURVIVAL CURVES;

DOSIMETRY;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CHO CELL; CLONOGENIC ASSAY; CONTROLLED STUDY; FIBROBLAST CULTURE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IRRADIATION; MONTE CARLO METHOD; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; RADIATION DOSE; RADIOSENSITIVITY; STATISTICAL MODEL; STUDENT T TEST; SURVIVAL RATE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLIOBLASTOMA; HUMANS; MALE; MODELS, BIOLOGICAL; PROSTATIC NEOPLASMS; RADIATION TOLERANCE; RADIOBIOLOGY; RADIOMETRY; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 33744799703     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/51/11/009     Document Type: Article

References (27)

1. Barendsen G W 1997 Parameters of linear-quadratic radiation dose-effect relationships, dependence on LET and mechanisms of reproductive cell death Int. J. Radiat. Biol. 71 649-55
2. Bartkowiak D, Hogner S, Nothdurft W and Rottinger E M 2001 Cell cycle and growth response of CHO cells to x-irradiation: threshold-free repair at low doses Int. J. Radiat. Oncol. Biol. Phys. 50 221-7
3. Brenner D J, Hahnfeldt P, Amundson S A and Sachs R K 1996 Interpretation of inverse dose-rate effects for mutagenesis by sparsely ionizing radiation Int. J. Radiat. Biol. 70 447-58
4. Brenner D J and Hall E J 1991 Conditions for the equivalence of continuous to pulsed low dose rate brachytherapy Int. J. Radiat. Oncol. Biol. Phys. 20 181-90
5. Carlone M, Wilkins D and Raaphorst G P 2005 The modified linear-quadratic model of Guerrero and Li can be derived from mechanistic basis and exhibits linear-quadratic-linear behavior Phys. Med. Biol. 50 L9-15
6. Chadwick K H and Leenhouts H P 1973 A molecular theory of cell survival Phys. Med. Biol. 18 78-87
7. Chapman J D 2003 Single-hit mechanism of tumor cell killing by radiation Int. J. Radiat. Biol. 79 71-81
8. Curtis S B 1986 Lethal and potentially lethal lesions induced by radiation-a unified repair model Radiat. Res. 106 252-70
9. Deschavanne P J, Fertil B, Chavaudra N and Malaise E P 1990 The relationship between radiosensitivity and repair of potentially lethal damage in human tumor cell lines with implications for radioresponsiveness Radiat. Res. 122 29-37
10. Dodds D, Symonds R P, Deehan C, Habeshaw T, Reed N S and Lamont D W 1996 A linear quadratic analysis of gynaecological brachytherapy Clin. Oncol. (R. Coll. Radiol.) 8 90-6
11. Fowler J F 1989 The linear-quadratic formula and progress in fractionated radiotherapy Br. J. Radiol. 62 679-94
12. Guerrero M and Li X A 2004 Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy Phys. Med. Biol. 49 4825-35
13. Hendry J H, Bentzen S M, Dale R G, Fowler J F, Wheldon T E, Jones B, Munro A J, Slevin N J and Robertson A G 1996 A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy Clin. Oncol. (R. Coll. Radiol.) 8 297-307
14. Joiner M C, Marples B, Lambin P, Short S C and Turesson I 2001 Low-dose hypersensitivity: current status and possible mechanisms Int. J. Radiat. Oncol. Biol. Phys. 49 379-89
15. Jones B, Tan L T and Dale R G 1995 Derivation of the optimum dose per fraction from the linear quadratic model Br. J. Radiol. 68 894-902
16. Marchese M J, Zaider M and Hall E J 1987 Dose-rate effects in normal and malignant cells of human origin Br. J. Radiol. 60 573-6
17. Marples B, Lambin P, Skov K A and Joiner M C 1997 Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells Int. J. Radiat. Biol. 71 721-35
18. 2-phase cells Radiat. Res. 161 247-55
19. Peacock J H, De Almodovar M R, McMillan T J and Steel G G 1992 The nature of the initial slope of radiation cell survival curves Br. J. Radiol. 24 S57-60
20. Puck T T and Marcus P I 1956 Action of x-rays on mammalian cells J. Exp. Med. 103 653-66
21. Raaphorst G P and Boyden S 1999 Adaptive response and its variation in human normal and tumor cells Int. J. Radiat. Biol. 75 865-73
22. Robertson C, Robertson A G, Hendry J H, Roberts S A, Slevin N J and Duncan W B 1998 Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers Int. J. Radiat. Oncol. Biol. Phys. 40 319-29
23. Sachs R K, Hahnfeldt P and Brenner D J 1997 Review: the link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair Int. J. Radiat. Biol. 72 351-74
24. Schmid E, Roos H, Rimpl G and Bauchinger M 1997 Chromosome aberration frequencies in human lymphocytes irradiated in a multi-layer array by protons with different LET Int. J. Radiat. Biol. 72 661-5
25. Tobias C A 1985 The repair-misrepair model in radiobiology: comparison to other models Radiat. Res. 8 S77-95
26. Whithers H R 1985 Biologic basis for altered fractionation schemes Cancer 55 2086-95
27. Zaider M 1991 Evidence of a neutron RBE of 70 (±50) for solid-tumor induction at Hiroshima and Nagasaki and its implications for assessing the effective neutron quality factor Health. Phys. 61 631-6