The radiobiological effect of intra-fraction dose-rate modulation in intensity modulated radiation therapy (IMRT)

Physics in Medicine and Biology

Volumn 53, Issue 13, 2008, Pages 3567-3578

  Bewes, J M ^a,b   Suchowerska, N ^a,b   Jackson, M ^b   Zhang, M ^b   McKenzie, D R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; HEALTH; MODULATION; RADIOTHERAPY; TUMORS;

CELL LINES; CELL SURVIVALS; CLONOGENIC ASSAYS; DELIVERY TIMES; DOSE RATES; IN VITRO STUDIES; INSTITUTE OF PHYSICS; INTENSITY MODULATED RADIATION THERAPY (IMRP); MELANOMA (MM); MULTI-LEAF COLLIMATOR (MLC); NON-SMALL CELL LUNG CANCER (NSCLC); OPTIMAL DOSE; PULSE AMPLITUDES; RADIATION DOSE; RADIATION FIELDS; RADIOBIOLOGICAL EFFECTS; REGIONAL VARIATIONS; SURVIVAL FRACTION (SF); TOTAL DOSE; TREATMENT TIMES;

PHYSICAL THERAPY;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTENSITY MODULATED RADIATION THERAPY; LUNG NON SMALL CELL CANCER; MELANOMA; PRIORITY JOURNAL; RADIATION DOSE; RADIOBIOLOGY;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DOSE FRACTIONATION; HUMANS; MELANOMA; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 47649109675     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/53/13/012     Document Type: Article

References (18)

1. Altman M B, Chmura S J, Deasy J O and Roeske J C 2006 Optimization of the temporal pattern of radiation: an IMRT based study Int. J. Radiat. Oncol. Biol. Phys. 66 898-905
2. American Psychological Association 2001 Publication Manual of the American Psychological Association 5th edn (Washington, DC: American Psychological Association)
3. Bewes J, Suchowerska N, Zhang M, Claridge E and McKenzie D R 2007 An economical and reliable method for automated quantitative analysis of in vitro cell colonies EPSM-ABEC (Fremantle) p 169
4. Claridge-Mackonis E, Suchowerska N, Zhang M, Ebert M, McKenzie D R and Jackson M 2007 Cellular response to modulated radiation fields Phys. Med. Biol. 52 5469-82
5. Dubrovsky V et al 2003 On the possible mechanisms of activation changes of enzymes under pulsed irradiation J. Russ. Laser Res. 24 289-300
6. Fowler J F, Welsh J S and Howard S P 2004 Loss of biological effect in prolonged fraction delivery Int. J. Radiat. Oncol. Biol. Phys. 59 242-9
7. Hall E and Giaccia A 2006 Radiobiology for the Radiologist 6th edn (Philadelphia: Lippincott Williams & Wilkins) p 34
8. Metcalfe P, Kron T and Hoban P 1997 The Physics of Radiotherapy X-Rays from Linear Accelerators (Madison: Medical Physics Publishing)
9. Mogili N, Joiner M and Burmeister J 2006 Effects of IMRT treatment time prolongation on tumor cell survival Med. Phys. 33 2294
10. Moiseenko V, Duzenli C and Durand R 2007 In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery Med. Phys. 34 1514-20
11. Mu X, Lofroth P, Karlsson M and Zackrisson B 2003 The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimisation problem Radiother. Oncol. 68 181-7
12. Murphy M J, Lin P and Ozhasoglu C 2007 Intra-fraction dose delivery timing during stereotactic radiotherapy can influence the radiobiological effect Med. Phys. 34 481-4
13. Ogino H, Shibamoto Y, Sugie C and Ito M 2005 Biological effects of intermittent radiation in tumor cells: influence of fraction number and dose per fraction J. Radiat. Res. 46 401-6
14. Paganetti H 2005 Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 63 892-900
15. Shibamoto Y, Ito M, Sugie C, Ogino H and Hara M 2004 Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and IMRT Int. J. Radiat. Oncol. Biol. Phys. 59 1484-90
16. Sterzing F, Munter M W and Schafer M 2005 Radiobiological investigation of dose-rate effects in intensity-modulated radiation therapy Strahlenther. Onkol. 181 42-8
17. Suchowerska N, Ebert M A, Zhang M and Jackson M 2005 In vitro response of tumor cells to non-uniform irradiation Phys. Med. Biol. 50 3041-51
18. Wang J Z, Li X, D'Souza W D and Stewart R D 2003 Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT) Int. J. Radiat. Oncol. Biol. Phys. 57 543-52