Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine

International Journal of Oncology

Volumn 36, Issue 4, 2010, Pages 973-982

  Skipworth, Richard J E ^a   Stewart, Grant D ^a   Bhana, Mishaim ^a   Christie, Jennifer ^a   Sturgeon, Catharine M ^b   Guttridge, Denis C ^c   Cronshaw, Andrew D ^a   Fearon, Kenneth C H ^a   Ross, James A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Biomarkers; Cachexia; Cancer; Mass spectrometry; Urine

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA2 GLYCOPROTEIN; BIOLOGICAL MARKER; BULLOUS PEMPHIGOID ANTIGEN 1; C MYC INTRON BINDING PROTEIN 1; CHROMOSOME 14 OPEN READING FRAME 78; CREATINE KINASE; CREATININE; CYTOSKELETON PROTEIN; FODRIN; IMMUNOGLOBULIN KAPPA CHAIN; MICROTUBULE ACTIN CROSSLINKING FACTOR; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 5; MUSCLE PROTEIN; MYOSIN 10; MYOSIN 5 C; MYOSIN 7 A; MYOSIN 9 A; NISCHARIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; CACHEXIA; CANCER CACHEXIA; CLINICAL ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DEMOGRAPHY; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN URINE LEVEL; PROTEOMICS; SQUAMOUS CELL CARCINOMA; URINALYSIS; URINARY EXCRETION; URINE;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CACHEXIA; CASE-CONTROL STUDIES; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE PROTEINS; PREDICTIVE VALUE OF TESTS; PROTEINURIA; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STOMACH NEOPLASMS; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 77749287010     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000577     Document Type: Article

References (58)

1. DeWys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, Cohen MH, Douglass HO Jr, Engstrom PF, Ezdinli EZ, Horton J, Johnson GJ, Moertel CG, Oken MM, Perlia C, Rosenbaum C, Silverstein MN, Skeel RT, Sponzo RW and Tormey DC: Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 69: 491-497, 1980.
2. Nixon DW, Lawson DH, Kutner M, Ansley J, Schwarz M, Heymsfield S, Chawla R, Cartwright TH and Rudman D: Hyperalimentation of the cancer patient with protein-calorie undernutrition. Cancer Res 41: 2038-2045, 1981.
3. Dejong CH, Busquets S, Moses AG, Schrauwen P, Ross JA, Argiles JM and Fearon KC: Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia. Oncol Rep 14: 257-263, 2005.
4. Barber MD, Fearon KC and Ross JA: Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer. Clin Sci (Lond) 96: 83-87, 1999.
5. Deans DA, Wigmore SJ, Gilmour H, Paterson-Brown S, Ross JA and Fearon KC: Elevated tumour interleukin-1beta is associated with systemic inflammation: a marker of reduced survival in gastro-oesophageal cancer. Br J Cancer 95: 1568-1575, 2006.
6. O'Riordain MG, Falconer JS, Maingay J, Fearon KC and Ross JA: Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism. Int J Oncol 15: 823-827, 1999.
7. Costelli P, Tullio RD, Baccino FM and Melloni E: Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia. Br J Cancer 84: 946-950, 2001.
8. Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S and Guttridge DC: Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest 114: 370-378, 2004.
9. Acharyya S, Butchbach ME, Sahenk Z, Wang H, Saji M, Carathers M, Ringel MD, Skipworth RJ, Fearon KC, Hollingsworth MA, Muscarella P, Burghes AH, Rafael-Fortney JA and Guttridge DC: Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell 8: 421-432, 2005.
10. Weber MA Kinscherf R, Krakowski-Roosen H, Aulmann M, Renk H, Künkele A, Edler L, Kauczor HU and Hildebrandt W: Myoglobin plasma level related to muscle mass and fiber composition: a clinical marker of muscle wasting? J Mol Med 85: 887-896, 2007.
11. Pedersen LM and Milman N: Prevalence and prognostic significance of proteinuria in patients with lung cancer. Acta Oncol 35: 691-695, 1996.
12. Pieper R, Gatlin CL, Makusky AJ Russo PS, Schatz CR, Miller SS, Su Q, McGrath AM, Estock MA, Parmar PP, Zhao M, Huang ST, Zhou J, Wang F, Esquer-Blasco R, Anderson NL, Taylor J and Steiner S: The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins. Proteomics 3: 1345-1364, 2003.
13. Zerefos PG and Vlahou A: Urine sample preparation and protein profiling by two-dimensional electrophoresis and matrix-assisted laser desorption ionization time of flight mass spectroscopy. Methods Mol Biol 428: 141-157, 2008.
14. Robijn ML, Planken J, Kornelis D, Hokke CH and Deelder AM: Mass spectrometric detection of urinary oligosaccharides as markers of Schistosoma mansoni infection. Trans R Soc Trop Med Hyg 102: 79-83, 2006.
15. Kammerer B, Frickenschmidt A, Gleiter CH, Laufer S and Liebich H: MALDI-TOF MS analysis of urinary nucleosides. J Am Soc Mass Spectrom 16: 940-947, 2005.
16. Lapolla A, Ragazzi E, Andretta B, Fedele D, Tubaro M, Seraglia R, Molin L and Traldi P: Multivariate analysis of matrix-assisted laser desorption/ionization mass spectrometric data related to glycoxidation products of human globins in nephropathic patients. J Am Soc Mass Spectrom 18: 1018-1023, 2007.
17. Lin CY, Tsui KH, Yu CC, Yeh CW, Chang PL and Yung BY: Searching cell-secreted proteomes for potential urinary bladder tumour markers. Proteomics 6: 4381-4389, 2006.
18. M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM and Bhowmick NA: Detection of preneoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem Biophys Res Commun 353: 829-834, 2007.
19. Kojima K, Asmellash S, Klug CA, Grizzle WE, Mobley JA and Christein JD: Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer. J Gastrointest Surg 12: 1683-1690, 2008.
20. Ward DG, Nyangoma S, Joy H, Hamilton E, Wei W, Tselepis C, Steven N, Wakelam MJ, Johnson PJ, Ismail T and Martin A: Proteomic profiling of urine for the detection of colon cancer. Proteome Sci 6: 19, 2008.
21. Echan LA, Tang HY, Li-Khan N, Lee K and Speicher DW: Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma. Proteomics 5: 3292-3303, 2005.
22. Thompson RF and Langford GM: Myosin superfamily evolutionary history. Anat Rec 68: 276-289, 2002.
23. Wu X, Jung G and Hammer JA III: Functions of unconventional myosins. Curr Opin Cell Biol 12: 42-51, 2000.
24. Vikstrom KL, Seiler SH, Sohn RL, Strauss M, Weiss A, Welikson RE and Leinwand LA: The vertebrate myosin heavy chain: genetics and assembly properties. Cell Struct Funct 22: 123-129, 1997.
25. Mehl KA, Davis JM, Berger FG and Carson JA: Myofiber degeneration/ regeneration is induced in the cachectic ApcMin/+ mouse. J Appl Physiol 99: 2379-2387, 2005.
26. Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S and Lanfranchi G: Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. J Mol Biol 326: 137-149, 2003.
27. Huh GY, Glantz SB, Je S, Morrow JS and Kim JH: Calpain proteolysis of alpha II-spectrin in the normal adult human brain. Neurosci Lett 316: 41-44, 2001.
28. Lee S, Baek M, Yang H, Bang YJ, Kim WH, Ha JH, Kim DK and Jeoung DI: Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. Cancer Lett 184: 197-206, 2002.
29. Alahari SK, Lee JW and Juliano RL: Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J Cell Biol 151: 1141-1154, 2000.
30. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH and Calderwood DA: Talin binding to integrin beta tails: a final common step in integrin activation. Science 302: 103-106, 2003.
31. Franco SJ, Rodgers MA, Perrin BJ, Han J, Bennin DA, Critchley DR and Huttenlocher A: Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol 6: 977-983, 2004.
32. Yamauchi E, Titani K and Taniguchi H: Specific binding of acidic phospholipids to microtubule-associated protein MAP1B regulates its interaction with tubulin. J Biol Chem 272: 22948-22953, 1997.
33. Leung CL, Sun D, Zheng M, Knowles DR and Liem RK: Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons. J Cell Biol 147: 1275-1286, 1999.
34. Leung CL, Zheng M, Prater SM and Liem RK: The BPAG1 locus: alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles. J Cell Biol 154: 691-697, 2001.
35. Wieland BM, Stewart GD, Skipworth RJ, Sangster K, Fearon KC, Ross JA, Reiman TJ, Easaw J, Mourtzakis M, Kumar V, Pak BJ, Calder K, Filippatos G, Kremastinos DT, Palcic M and Baracos VE: Is there a human homologue to the murine proteolysis-inducing factor? Clin Cancer Res 13: 4984-4992, 2007.
36. Irmak S, Tilki D, Heukeshoven J, Oliveira-Ferrer L, Friedrich M, Huland H and Ergün S: Stage-dependent increase of orosomucoid and zinc-alpha2-glycoprotein in urinary bladder cancer. Proteomics 5: 4296-4304, 2005.
37. Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, Cinti S, Tisdale MJ and Trayhurn P: Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci USA 101: 2500-2505, 2004.
38. Todorov P, Cariuk P, McDevitt T, Coles B, Fearon K and Tisdale M: Characterization of a cancer cachectic factor. Nature 379: 739-742, 1996.
39. Pieper R, Gatlin CL, McGrath AM, Makusky AJ, Mondal M, Seonarain M, Field E, Schatz CR, Estock MA, Ahmed N, Anderson NG and Steiner S: Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics 4: 1159-1174, 2004.
40. Tantipaiboonwong P, Sinchaikul S, Sriyam S, Phutrakul S and Chen ST: Different techniques for urinary protein analysis of normal and lung cancer patients. Proteomics 5: 1140-1149, 2005.
41. Papale M, Pedicillo MC, Thatcher BJ, Di Paolo S, Lo Muzio L, Bufo P, Rocchetti MT, Centra M, Ranieri E and Gesualdo L: Urine profiling by SELDI-TOF/MS: monitoring of the critical steps in sample collection, handling and analysis. J Chromatogr B Analyt Technol Biomed Life Sci 856: 205-213, 2007.
42. Sigdel TK, Lau K, Schilling J and Sarwal M: Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation. Clin Transplant 22: 617-623, 2008.
43. Zerefos P, Prados J, Kossida S, Kalousis A and Vlahou A: Sample preparation and bioinformatics in MALDI profiling of urinary proteins. J Chromatogr B Analyt Technol Biomed Life Sci 853: 20-30, 2007.
44. Fearon KC, Voss AC and Hustead DS: Cancer Cachexia Study Group: Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis. Am J Clin Nutr 83: 1345-1350, 2006.
45. Fukuda S, Yamasaki Y, Iwaki T, Kawasaki H, Akieda S, Fukuchi N, Tahira T and Hayashi K: Characterization of the biological functions of a transcription factor, c-myc intron binding protein 1 (MIBP1). J Biochem 131: 349-357, 2002.
46. Takagi T, Harada J and Ishii S: Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol 2: 1048-1053, 2001.
47. Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A and Sterchi E: Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. J Biol Chem 273: 3076-3081, 1998.
48. Meugnier E, Bossu C, Oliel M, Jeanne S, Michaut A, Sothier M, Brozek J, Rome S, Laville M and Vidal H: Changes in gene expression in skeletal muscle in response to fat overfeeding in lean men. Obesity (Silver Spring) 15: 2583-2594, 2007.
49. Rodriguez OC and Cheney RE: Human myosin-Vc is a novel class V myosin expressed in epithelial cells. J Cell Sci 115: 991-1004, 2002.
50. Mouglabey YB, Nimri S, Sayegh F, El ZE and Slim R: Map refinement of the Usher syndrome type 1B gene, MYO7A, relative to 11q13.5 microsatellite markers. Clin Genet 54: 155-158, 1998.
51. McNally EM: Beta-myosin heavy chain gene mutations in familial hypertrophic cardiomyopathy: the usual suspect? Circ Res 90: 246-247, 2002.
52. Tajsharghi H, Oldfors A, Macleod DP and Swash M: Homozygous mutation in MYH7 in myosin storage myopathy and cardiomyopathy. Neurology 68: 962, 2007.
53. Lamont PJ, Udd B, Mastaglia FL, de Visser M, Hedera P, Voit T, Bridges LR, Fabian V, Rozemuller A and Laing NG: Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy. J Neurol Neurosurg Psychiatry 77: 208-215, 2006.
54. Reinhard J, Scheel AA, Diekmann D, Hall A, Ruppert C and Bähler M: A novel type of myosin implicated in signalling by rho family GTPases. EMBO J 14: 697-704, 1995.
55. Gorman SW, Haider NB, Grieshammer U, Swiderski RE, Kim E, Welch JW, Searby C, Leng S, Carmi R, Sheffield VC and Duhl DM: The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23. Genomics 59: 150-160, 1999.
56. Woolner S, O'Brien LL, Wiese C and Bement WM: Myosin-10 and actin filaments are essential for mitotic spindle function. J Cell Biol 182: 77-88, 2008.
57. Berg JS, Derfler BH, Pennisi CM, Corey DP and Cheney RE: Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. J Cell Sci 113: 3439-3451, 2000.
58. Alahari SK: Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK. Exp Cell Res 288: 415-424, 2003.