The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles

Journal of Cell Biology

Volumn 154, Issue 4, 2001, Pages 691-697

  Leung, Conrad L ^a   Zheng, Min ^a   Prater, Susan M ^a   Liem, Ronald K H ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Actin; Intermediate filaments; Microfilaments; Microtubules; Plakin

Indexed keywords

BULLOUS PEMPHIGOID ANTIGEN 1; CYTOSKELETON PROTEIN; INTERMEDIATE FILAMENT PROTEIN; ISOPROTEIN; MESSENGER RNA; MICROTUBULE ACTIN CROSS LINKING FACTOR; MICROTUBULE PROTEIN; PLAKIN; PROTEIN MACF; SPECTRIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DEGENERATIVE DISEASE; EMBRYO; GENE LOCUS; IN SITU HYBRIDIZATION; MOUSE; MUSCLE CELL; NERVE CELL; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; SENSORY NERVE; TISSUE SPECIFICITY;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BINDING SITES; CARRIER PROTEINS; CLONING, MOLECULAR; COLLAGEN; CYTOSKELETAL PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; NERVE TISSUE PROTEINS; NON-FIBRILLAR COLLAGENS; PEMPHIGOID, BULLOUS; PROTEIN ISOFORMS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0035921424     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200012098     Document Type: Article

References (18)

1. Dystonin expression in the developing nervous system predominates in the neurons that degenerate in dystonia musculorum mutant mice
2. Dystonin transcripts are altered and their levels are reduced in the mouse neurological mutant dt24J
3. Dystonin is an essential component of the Schwann cell cytoskeleton at the time of myelination
4. The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1
5. Dystonin is essential for maintaining neuronal cytoskeleton organization
6. Dystonin-deficient mice exhibit an intrinsic muscle weakness and an instability of skeletal muscle cytoarchitecture
7. Developmental expression of BPAG1-n: Insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice
8. Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
9. Short stop is allelic to kakapo, and encodes rod-like cytoskeletal-associated proteins required for axon extension
10. The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons
11. Microtubule actin cross-linking factor (MACF). A hybrid of dystonin and dystrophin that can interact with the actin and microtubule cyroskeletons
12. The kakapo mutation affects terminal arborization and central dendritic sprouting of Drosophila motor neurons
13. The plakin family: Versatile organizers of cytoskeletal architecture
14. Human bullous pemphigoid antigen (BPAG1). Amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains
15. Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): Identification of a novel group of microtubule associated proteins
16. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments
17. Integrators of the cyroskeleton that stabilize microtubules
18. Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system