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Volumn 192, Issue 5, 2010, Pages 1377-1386

Multidrug efflux pump MdtBC of Escherichia coli is active only as a B 2C heterotrimer

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BACTERIAL PROTEIN; MULTIDRUG EFFLUX PUMP PROTEIN; POLYHISTIDINE TAG; UNCLASSIFIED DRUG;

EID: 77749279768     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01448-09     Document Type: Article
Times cited : (41)

References (31)
  • 1
    • 0036066806 scopus 로고    scopus 로고
    • The baeSR two-component system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate
    • Baranova, N., and H. Nikaido. 2002. The baeSR two-component system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J. Bacteriol. 184:4168-4176.
    • (2002) J. Bacteriol , vol.184 , pp. 4168-4176
    • Baranova, N.1    Nikaido, H.2
  • 3
    • 0017807890 scopus 로고
    • Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid
    • Chang, A. C., and S. N. Cohen. 1978. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J. Bacteriol. 134:1141-1156.
    • (1978) J. Bacteriol , vol.134 , pp. 1141-1156
    • Chang, A.C.1    Cohen, S.N.2
  • 4
    • 0034612342 scopus 로고    scopus 로고
    • One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
    • Datsenko, K. A., and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U. S. A. 97:6640-6645.
    • (2000) Proc. Natl. Acad. Sci. U. S. A , vol.97 , pp. 6640-6645
    • Datsenko, K.A.1    Wanner, B.L.2
  • 5
    • 0036889033 scopus 로고    scopus 로고
    • Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops
    • Elkins, C. A., and H. Nikaido. 2002. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops. J. Bacteriol. 184:6490-6498.
    • (2002) J. Bacteriol , vol.184 , pp. 6490-6498
    • Elkins, C.A.1    Nikaido, H.2
  • 6
    • 9944247705 scopus 로고    scopus 로고
    • Three's company. Component structures bring a closer view of tripartite drug efflux pumps
    • Eswaran, J., E. Koronakis, M. K. Higgins, C. Hughes, and V. Koronakis. 2004. Three's company. Component structures bring a closer view of tripartite drug efflux pumps. Curr. Opin. Struct. Biol. 14:741-747.
    • (2004) Curr. Opin. Struct. Biol , vol.14 , pp. 741-747
    • Eswaran, J.1    Koronakis, E.2    Higgins, M.K.3    Hughes, C.4    Koronakis, V.5
  • 7
    • 0035110804 scopus 로고    scopus 로고
    • Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa
    • Guan, L., and T. Nakae. 2001. Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa. J. Bacteriol. 183:1734-1739.
    • (2001) J. Bacteriol , vol.183 , pp. 1734-1739
    • Guan, L.1    Nakae, T.2
  • 8
    • 0034702177 scopus 로고    scopus 로고
    • Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
    • Koronakis, V., A. Sharff, E. Koronakis, B. Luisi, and C. Hughes. 2002. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405:914-919.
    • (2002) Nature , vol.405 , pp. 914-919
    • Koronakis, V.1    Sharff, A.2    Koronakis, E.3    Luisi, B.4    Hughes, C.5
  • 9
    • 0030271498 scopus 로고    scopus 로고
    • Errors of heterologous protein expression
    • Kurland, C., and J. Gallant. 1996. Errors of heterologous protein expression. Curr. Opin. Biotechnol. 7:489-493.
    • (1996) Curr. Opin. Biotechnol , vol.7 , pp. 489-493
    • Kurland, C.1    Gallant, J.2
  • 10
    • 0442307441 scopus 로고    scopus 로고
    • Efflux-mediated drug resistance in bacteria
    • Li, X.-Z., and H. Nikaido. 2004. Efflux-mediated drug resistance in bacteria. Drugs 64:159-204.
    • (2004) Drugs , vol.64 , pp. 159-204
    • Li, X.-Z.1    Nikaido, H.2
  • 11
    • 33644833626 scopus 로고    scopus 로고
    • Conformational flexibility in the multidrug efflux system protein AcrA
    • Mikolosko, J., K. Bobyk, H. I. Zgurskaya, and P. Ghosh. 2006. Conformational flexibility in the multidrug efflux system protein AcrA. Structure 14:577-587.
    • (2006) Structure , vol.14 , pp. 577-587
    • Mikolosko, J.1    Bobyk, K.2    Zgurskaya, H.I.3    Ghosh, P.4
  • 13
    • 33748670458 scopus 로고    scopus 로고
    • Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    • Murakami, S., R. Nakashima, E. Yamashita, T. Matsumoto, and A. Yamaguchi. 2006. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443:173-179.
    • (2006) Nature , vol.443 , pp. 173-179
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Matsumoto, T.4    Yamaguchi, A.5
  • 14
    • 0037057652 scopus 로고    scopus 로고
    • Crystal structure of bacterial multidrug efflux transporter AcrB
    • Murakami, S., R. Nakashima, E. Yamashita, and A. Yamaguchi. 2002. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419:587-593.
    • (2002) Nature , vol.419 , pp. 587-593
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Yamaguchi, A.4
  • 15
    • 0036064516 scopus 로고    scopus 로고
    • The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC
    • Nagakubo, S., K. Nishino, T. Hirata, and A. Yamaguchi. 2002. The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J. Bacteriol. 184:4161-4167.
    • (2002) J. Bacteriol , vol.184 , pp. 4161-4167
    • Nagakubo, S.1    Nishino, K.2    Hirata, T.3    Yamaguchi, A.4
  • 16
    • 65249172043 scopus 로고    scopus 로고
    • Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli
    • Nagano, K., and H. Nikaido. 2009. Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 106:5854-5858.
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 5854-5858
    • Nagano, K.1    Nikaido, H.2
  • 17
    • 65249146929 scopus 로고    scopus 로고
    • Multidrug resistance in bacteria
    • Nikaido, H. 2009. Multidrug resistance in bacteria. Annu. Rev. Biochem. 78:119-146.
    • (2009) Annu. Rev. Biochem , vol.78 , pp. 119-146
    • Nikaido, H.1
  • 18
    • 0029845913 scopus 로고    scopus 로고
    • Multidrug efflux pumps of gram-negative bacteria
    • Nikaido, H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
    • (1996) J. Bacteriol , vol.178 , pp. 5853-5859
    • Nikaido, H.1
  • 19
    • 0030029513 scopus 로고    scopus 로고
    • AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
    • Okusu, H., D. Ma, and H. Nikaido. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178:306-308.
    • (1996) J. Bacteriol , vol.178 , pp. 306-308
    • Okusu, H.1    Ma, D.2    Nikaido, H.3
  • 21
    • 0026409298 scopus 로고
    • Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form
    • Schägger, H., and G. von Jagow. 1991. Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal. Biochem. 199:223-231.
    • (1991) Anal. Biochem , vol.199 , pp. 223-231
    • Schägger, H.1    von Jagow, G.2
  • 22
    • 33748310520 scopus 로고    scopus 로고
    • Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
    • Seeger, M. A., A. Schiefner, T. Eicher, F. Verrey, K. Diedrichs, and K. M. Pos. 2006. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science 313:1295-1298.
    • (2006) Science , vol.313 , pp. 1295-1298
    • Seeger, M.A.1    Schiefner, A.2    Eicher, T.3    Verrey, F.4    Diedrichs, K.5    Pos, K.M.6
  • 23
    • 67649583295 scopus 로고    scopus 로고
    • Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: Evidence from site-directed mutagenesis and carbodiimide labeling
    • Seeger, M. A., C. von Ballmoos, F. Verrey, and K. M. Pos. 2009. Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling. Biochemistry 48:5801-5812.
    • (2009) Biochemistry , vol.48 , pp. 5801-5812
    • Seeger, M.A.1    von Ballmoos, C.2    Verrey, F.3    Pos, K.M.4
  • 25
    • 33749632749 scopus 로고    scopus 로고
    • Conformation of the AcrB multidrug efflux pump in mutants of the putative proton-relay pathway
    • Su, C. C., M. Li, R. Gu, Y. Takatsuka, G. McDermott, H. Nikaido, and E. W. Yu. 2006. Conformation of the AcrB multidrug efflux pump in mutants of the putative proton-relay pathway. J. Bacteriol. 188:7290-7296.
    • (2006) J. Bacteriol , vol.188 , pp. 7290-7296
    • Su, C.C.1    Li, M.2    Gu, R.3    Takatsuka, Y.4    McDermott, G.5    Nikaido, H.6    Yu, E.W.7
  • 28
    • 33749630424 scopus 로고    scopus 로고
    • Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network
    • Takatsuka, Y., and H. Nikaido. 2006. Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network. J. Bacteriol. 188:7284-7289.
    • (2006) J. Bacteriol , vol.188 , pp. 7284-7289
    • Takatsuka, Y.1    Nikaido, H.2
  • 29
    • 63049131979 scopus 로고    scopus 로고
    • Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism
    • Takatsuka, Y., and H. Nikaido. 2009. Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism. J. Bacteriol. 191:1729-1737.
    • (2009) J. Bacteriol , vol.191 , pp. 1729-1737
    • Takatsuka, Y.1    Nikaido, H.2
  • 30
    • 0023571657 scopus 로고
    • High-copy-number and low-copy-number plasmid vectors for lacZ alpha-complementation and chloramphenicol- or kanamycin-resistance selection
    • Takeshita, S., M. Sato, M. Toba, W. Masahashi, and T. Hashimoto-Gotoh. 1987. High-copy-number and low-copy-number plasmid vectors for lacZ alpha-complementation and chloramphenicol- or kanamycin-resistance selection. Gene 61:63-74.
    • (1987) Gene , vol.61 , pp. 63-74
    • Takeshita, S.1    Sato, M.2    Toba, M.3    Masahashi, W.4    Hashimoto-Gotoh, T.5
  • 31
    • 0033594886 scopus 로고    scopus 로고
    • Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
    • Zgurskaya, H. I., and H. Nikaido. 1999. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 96:7190-7195.
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 7190-7195
    • Zgurskaya, H.I.1    Nikaido, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.