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Volumn 40, Issue 3, 2010, Pages 899-910

DNA vaccination with T-cell epitopes encoded within Ab molecules induces high-avidity anti-tumor CD8+ T cells

Author keywords

CTL; Epitopes; Tumor immunity; Vaccination

Indexed keywords

DNA ANTIBODY; DNA VACCINE; EPITOPE; FC RECEPTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A;

EID: 77749245797     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939857     Document Type: Article
Times cited : (23)

References (44)
  • 1
    • 0033556322 scopus 로고    scopus 로고
    • High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
    • Zeh, H. J., Perry-Lalley, D., Dudley, M. E., Rosenberg, S. A. and Yang, J. C., High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy. J. Immunol. 1999. 162: 989-994.
    • (1999) J. Immunol , vol.162 , pp. 989-994
    • Zeh, H.J.1    Perry-Lalley, D.2    Dudley, M.E.3    Rosenberg, S.A.4    Yang, J.C.5
  • 2
    • 0035423121 scopus 로고    scopus 로고
    • Heterogeneous T-cell response to MAGA10254-262: High avidity-specific cytolytic T lymphocytes show superior antitumour activity
    • Dutoit, V., Rubio-Godoy, V., Dietrich, P., Quiqueres, A., Schnuriger, V., Rimoldi, D., Lienard, D. et al., Heterogeneous T-cell response to MAGA10254-262: High avidity-specific cytolytic T lymphocytes show superior antitumour activity. Cancer Res. 2001. 61: 5850-5853.
    • (2001) Cancer Res , vol.61 , pp. 5850-5853
    • Dutoit, V.1    Rubio-Godoy, V.2    Dietrich, P.3    Quiqueres, A.4    Schnuriger, V.5    Rimoldi, D.6    Lienard, D.7
  • 3
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller, M. A., Leggatt, G. R. and Berzofsky, J. A., Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 1996. 93: 4102-4107.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4102-4107
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 4
    • 0141481203 scopus 로고    scopus 로고
    • Tumor-reactive, SSX-2-specific CD8+ T cells are selectively expanded during immune responses to antigenexpressing tumors in melanoma patients
    • Ayyoub, M., Rimoldi, D., Guillaume, P., Romero, P., Cerottini, J. C., Valmori, D. and Speiser, D., Tumor-reactive, SSX-2-specific CD8+ T cells are selectively expanded during immune responses to antigenexpressing tumors in melanoma patients. Cancer Res. 2003. 63: 5601-5606.
    • (2003) Cancer Res , vol.63 , pp. 5601-5606
    • Ayyoub, M.1    Rimoldi, D.2    Guillaume, P.3    Romero, P.4    Cerottini, J.C.5    Valmori, D.6    Speiser, D.7
  • 5
    • 0034130519 scopus 로고    scopus 로고
    • In vivo induction of a high-avidity, high-frequency cytotoxic Tlymphocyte response is associated with antiviral protective immunity
    • Sedlik, C., Dadaglio, G., Saron, M. F., Deriaud, E., Rojas, M., Casal, S. I. and Leclerc, C., In vivo induction of a high-avidity, high-frequency cytotoxic Tlymphocyte response is associated with antiviral protective immunity. J. Virol. 2000. 74: 5769-5775.
    • (2000) J. Virol , vol.74 , pp. 5769-5775
    • Sedlik, C.1    Dadaglio, G.2    Saron, M.F.3    Deriaud, E.4    Rojas, M.5    Casal, S.I.6    Leclerc, C.7
  • 6
    • 0029813121 scopus 로고    scopus 로고
    • Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL
    • Alexander-Miller, M. A., Leggatt, G. R., Sarin, A. and Berzofsky, J. A., Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. J. Exp. Med. 1996. 184: 485-492.
    • (1996) J. Exp. Med , vol.184 , pp. 485-492
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Sarin, A.3    Berzofsky, J.A.4
  • 7
    • 34548597082 scopus 로고    scopus 로고
    • Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter
    • Kroger, C. J. and Alexander-Miller, M. A., Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology 2007. 122: 167-178.
    • (2007) Immunology , vol.122 , pp. 167-178
    • Kroger, C.J.1    Alexander-Miller, M.A.2
  • 8
    • 0024272306 scopus 로고
    • Antigen recognition by H-2-restricted cytolytic T lymphocytes: Inhibition of cytolysis by anti-CD8 monoclonal antibodies depends upon both concentration and primary sequence of peptide antigen
    • Maryanski, J. L., Pala, P., Cerottini, J. C. and MacDonald, H. R., Antigen recognition by H-2-restricted cytolytic T lymphocytes: inhibition of cytolysis by anti-CD8 monoclonal antibodies depends upon both concentration and primary sequence of peptide antigen. Eur. J. Immunol. 1988. 18: 1863-1866.
    • (1988) Eur. J. Immunol , vol.18 , pp. 1863-1866
    • Maryanski, J.L.1    Pala, P.2    Cerottini, J.C.3    MacDonald, H.R.4
  • 9
    • 0034235795 scopus 로고    scopus 로고
    • T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity
    • Sandberg, J. K., Franksson, L., Sundback, J., Michaelsson, J., Petersson, M., Achour, A., Wallin, R. P. A. et al., T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity. J. Immunol. 2000. 165: 25-33.
    • (2000) J. Immunol , vol.165 , pp. 25-33
    • Sandberg, J.K.1    Franksson, L.2    Sundback, J.3    Michaelsson, J.4    Petersson, M.5    Achour, A.6    Wallin, R.P.A.7
  • 10
    • 0345535130 scopus 로고    scopus 로고
    • Selective induction of high avidity CTL by altering the balance of signals from APC
    • Oh, S., Hodge, J. W., Ahlers, J. D., Burke, D. S., Schlom, J. and Berzofsky, J. A., Selective induction of high avidity CTL by altering the balance of signals from APC. J. Immunol. 2003. 170: 2523-2530.
    • (2003) J. Immunol , vol.170 , pp. 2523-2530
    • Oh, S.1    Hodge, J.W.2    Ahlers, J.D.3    Burke, D.S.4    Schlom, J.5    Berzofsky, J.A.6
  • 11
    • 0042931259 scopus 로고    scopus 로고
    • Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism
    • Xu, S., Koski, G. K., Faries, M., Bedrosian, I., Mick, R., Maeurer, M., Cheever, M. A. et al., Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism. J. Immunol. 2003. 171: 2251-2261.
    • (2003) J. Immunol , vol.171 , pp. 2251-2261
    • Xu, S.1    Koski, G.K.2    Faries, M.3    Bedrosian, I.4    Mick, R.5    Maeurer, M.6    Cheever, M.A.7
  • 12
    • 0035451399 scopus 로고    scopus 로고
    • Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: Correlation with CD8ab versus CD8aa expression
    • Cawthon, A. G., Lu, H. and Alexander-Miller, M. A., Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8ab versus CD8aa expression. J. Immunol. 2001. 167: 2577-2584.
    • (2001) J. Immunol , vol.167 , pp. 2577-2584
    • Cawthon, A.G.1    Lu, H.2    Alexander-Miller, M.A.3
  • 14
    • 0027398099 scopus 로고
    • Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule
    • Zaghouani, H., Steinman, R., Nonacs, R., Shah, H., Gerhard,W. and Bona, C., Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science 1993. 259: 224-227.
    • (1993) Science , vol.259 , pp. 224-227
    • Zaghouani, H.1    Steinman, R.2    Nonacs, R.3    Shah, H.4    Gerhard, W.5    Bona, C.6
  • 16
    • 0027451440 scopus 로고
    • Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus
    • Brumeanu, T. D., Swiggard, W. J., Steinman, R. M., Bona, C. A. and Zaghouani, H., Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus. J. Exp. Med. 1993. 178: 1795-1799.
    • (1993) J. Exp. Med , vol.178 , pp. 1795-1799
    • Brumeanu, T.D.1    Swiggard, W.J.2    Steinman, R.M.3    Bona, C.A.4    Zaghouani, H.5
  • 17
    • 0027505012 scopus 로고
    • Priming of cytotoxic T lymphocytes at various stages of ontogeny with transfectoma cells expressing a chimeric Ig heavy chain gene bearing an influenza virus nucleoprotein peptide
    • Kuzu, Y., Kuzu, H., Zaghouani, H. and Bona, C., Priming of cytotoxic T lymphocytes at various stages of ontogeny with transfectoma cells expressing a chimeric Ig heavy chain gene bearing an influenza virus nucleoprotein peptide. Int. Immunol. 1993. 5: 1301-1307.
    • (1993) Int. Immunol , vol.5 , pp. 1301-1307
    • Kuzu, Y.1    Kuzu, H.2    Zaghouani, H.3    Bona, C.4
  • 18
    • 0027366959 scopus 로고
    • Contrasting efficacy of presentation by major histocompatibility complex class I and class II products when peptides are administered within a common protein carrier, self immunoglobulin
    • Zaghouani, H., Kuzu, Y., Kuzu, H., Brumeanu, T. D., Swiggard, W. J., Steinman, R. M. and Bona, C. A., Contrasting efficacy of presentation by major histocompatibility complex class I and class II products when peptides are administered within a common protein carrier, self immunoglobulin. Eur. J. Immunol. 1993. 23: 2746-2750.
    • (1993) Eur. J. Immunol , vol.23 , pp. 2746-2750
    • Zaghouani, H.1    Kuzu, Y.2    Kuzu, H.3    Brumeanu, T.D.4    Swiggard, W.J.5    Steinman, R.M.6    Bona, C.A.7
  • 19
    • 31144456176 scopus 로고    scopus 로고
    • Immunologic control of tumors by in vivo Fc gamma receptor-targeted antigen loading in conjunction with double-stranded RNA-mediated immune modulation
    • Bot, A., Smith, D., Phillips, B., Bot, S., Bona, C. and Zaghouani, H., Immunologic control of tumors by in vivo Fc gamma receptor-targeted antigen loading in conjunction with double-stranded RNA-mediated immune modulation. J. Immunol. 2006. 176: 1363-1374.
    • (2006) J. Immunol , vol.176 , pp. 1363-1374
    • Bot, A.1    Smith, D.2    Phillips, B.3    Bot, S.4    Bona, C.5    Zaghouani, H.6
  • 20
    • 21044444425 scopus 로고    scopus 로고
    • Immune responses to the 105AD7 human antiidiotypic vaccine after intensive chemotherapy, for osteosarcoma
    • Pritchard-Jones, K., Spendlove, I., Wilton, C., Whelan, J., Weeden, S., Lewis, I., Hale, J. et al., Immune responses to the 105AD7 human antiidiotypic vaccine after intensive chemotherapy, for osteosarcoma. Br. J. Cancer 2005. 92: 1358-1365.
    • (2005) Br. J. Cancer , vol.92 , pp. 1358-1365
    • Pritchard-Jones, K.1    Spendlove, I.2    Wilton, C.3    Whelan, J.4    Weeden, S.5    Lewis, I.6    Hale, J.7
  • 22
    • 33846252319 scopus 로고    scopus 로고
    • A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55
    • Ullenhag, G. J., Spendlove, I.,Watson, N. F., Indar, A. A., Dube, M., Robins, R. A., Maxwell-Armstrong, C. et al., A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55. Clin. Cancer Res. 2006. 12: 7389-7396.
    • (2006) Clin. Cancer Res , vol.12 , pp. 7389-7396
    • Ullenhag, G.J.1    Spendlove, I.2    Watson, N.F.3    Indar, A.A.4    Dube, M.5    Robins, R.A.6    Maxwell-Armstrong, C.7
  • 23
    • 0035342538 scopus 로고    scopus 로고
    • Human anti-idiotypic antibodies can be good immunogens as they target FC receptors on antigen-presenting cells allowing efficient stimulation of both helper and cytotoxic T-cell responses
    • Durrant, L. G., Parsons, T., Moss, R., Spendlove, I., Carter, G. and Carr, F., Human anti-idiotypic antibodies can be good immunogens as they target FC receptors on antigen-presenting cells allowing efficient stimulation of both helper and cytotoxic T-cell responses. Int. J. Cancer 2001. 92: 414-420.
    • (2001) Int. J. Cancer , vol.92 , pp. 414-420
    • Durrant, L.G.1    Parsons, T.2    Moss, R.3    Spendlove, I.4    Carter, G.5    Carr, F.6
  • 24
    • 0029958448 scopus 로고    scopus 로고
    • Fanger, N. A.,Wardwell, K., Shen, L., Tedder, T. F. and Guyre, P. M., Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. J. Immunol. 1996. 157: 541-548.
    • Fanger, N. A.,Wardwell, K., Shen, L., Tedder, T. F. and Guyre, P. M., Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. J. Immunol. 1996. 157: 541-548.
  • 25
    • 14544308857 scopus 로고    scopus 로고
    • Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
    • Dhodapkar, K. M., Kaufman, J. L., Ehlers, M., Banerjee, D. K., Bonvini, E., Koenig, S., Steinman, R. M. et al., Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc. Natl. Acad. Sci. USA 2005. 102: 2910-2915.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2910-2915
    • Dhodapkar, K.M.1    Kaufman, J.L.2    Ehlers, M.3    Banerjee, D.K.4    Bonvini, E.5    Koenig, S.6    Steinman, R.M.7
  • 27
    • 34548794941 scopus 로고    scopus 로고
    • Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells
    • Kroger, C. J. and Alexander-Miller, M. A., Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. J. Immunol. 2007. 179: 748-751.
    • (2007) J. Immunol , vol.179 , pp. 748-751
    • Kroger, C.J.1    Alexander-Miller, M.A.2
  • 28
    • 7444254052 scopus 로고    scopus 로고
    • Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanoma-specific CD8+ T lymphocytes
    • De Palma, R., Marigo, I., Del Galdo, F., De Santo, C., Serafini, P., Cingarlini, S., Tuting, T. et al., Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanoma-specific CD8+ T lymphocytes. Cancer. Res. 2004. 64: 8068-8076.
    • (2004) Cancer. Res , vol.64 , pp. 8068-8076
    • De Palma, R.1    Marigo, I.2    Del Galdo, F.3    De Santo, C.4    Serafini, P.5    Cingarlini, S.6    Tuting, T.7
  • 29
    • 0027208560 scopus 로고
    • Peptide stability in drug development. II. Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum
    • Powell, M. F., Stewart, T., Otvos, L., Jr., Urge, L., Gaeta, F. C., Sette, A., Arrhenius, T. et al., Peptide stability in drug development. II. Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum. Pharm. Res. 1993. 10: 1268-1273.
    • (1993) Pharm. Res , vol.10 , pp. 1268-1273
    • Powell, M.F.1    Stewart, T.2    Otvos Jr., L.3    Urge, L.4    Gaeta, F.C.5    Sette, A.6    Arrhenius, T.7
  • 31
    • 85047696202 scopus 로고    scopus 로고
    • Genetic immunization with a melanocytic self-antigen linked to foreign helper sequences breaks tolerance and induces autoimmunity and tumor immunity
    • Steitz, J., Bruck, J., Gambotto, A., Knop, J. and Tuting, T., Genetic immunization with a melanocytic self-antigen linked to foreign helper sequences breaks tolerance and induces autoimmunity and tumor immunity. Gene Ther. 2002. 9: 208-213.
    • (2002) Gene Ther , vol.9 , pp. 208-213
    • Steitz, J.1    Bruck, J.2    Gambotto, A.3    Knop, J.4    Tuting, T.5
  • 33
    • 28844459086 scopus 로고    scopus 로고
    • Enhancement of immunity by a DNA melanoma vaccine against TRP2 with CCL21 as an adjuvant
    • Yamano, T., Kaneda, Y., Huang, S., Hiramatsu, S. H. and Hoon, D. S., Enhancement of immunity by a DNA melanoma vaccine against TRP2 with CCL21 as an adjuvant. Mol Ther 2006. 13: 194-202.
    • (2006) Mol Ther , vol.13 , pp. 194-202
    • Yamano, T.1    Kaneda, Y.2    Huang, S.3    Hiramatsu, S.H.4    Hoon, D.S.5
  • 34
    • 27144512475 scopus 로고    scopus 로고
    • Survival gene' Bcl-xl potentiates DNA-raised antitumor immunity
    • Kim, J. H., Chen, J., Majumder, N., Lin, H., Falo, L. D., Jr. and You, Z., 'Survival gene' Bcl-xl potentiates DNA-raised antitumor immunity. Gene Ther. 2005. 12: 1517-1525.
    • (2005) Gene Ther , vol.12 , pp. 1517-1525
    • Kim, J.H.1    Chen, J.2    Majumder, N.3    Lin, H.4    Falo Jr., L.D.5    You, Z.6
  • 35
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller, R. P., van Duivenvoorde, L. M., van Elsas, A., Schumacher, T. N., Wildenberg, M. E., Allison, J. P., Toes, R. E. et al., Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 2001. 194: 823-832.
    • (2001) J. Exp. Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    van Duivenvoorde, L.M.2    van Elsas, A.3    Schumacher, T.N.4    Wildenberg, M.E.5    Allison, J.P.6    Toes, R.E.7
  • 36
    • 0032555907 scopus 로고    scopus 로고
    • Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization
    • Porgador, A., Irvine, K. R., Iwasaki, A., Barber, B. H., Restifo, N. P. and Germain, R. N., Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J. Exp. Med. 1998. 188: 1075-1082.
    • (1998) J. Exp. Med , vol.188 , pp. 1075-1082
    • Porgador, A.1    Irvine, K.R.2    Iwasaki, A.3    Barber, B.H.4    Restifo, N.P.5    Germain, R.N.6
  • 37
    • 0035889924 scopus 로고    scopus 로고
    • Cross-priming as a predominant mechanism for inducing CD8(1) T cell responses in gene gun DNA immunization
    • Cho, J. H., Youn, J. W. and Sung, Y. C., Cross-priming as a predominant mechanism for inducing CD8(1) T cell responses in gene gun DNA immunization. J. Immunol. 2001. 167: 5549-5557.
    • (2001) J. Immunol , vol.167 , pp. 5549-5557
    • Cho, J.H.1    Youn, J.W.2    Sung, Y.C.3
  • 38
    • 43049144967 scopus 로고    scopus 로고
    • Antibody association with HER-2/neu-targeted vaccine enhances CD8 T cell responses in mice through Fc-mediated activation of DCs
    • Kim, P. S., Armstrong, T. D., Song, H., Wolpoe, M. E., Weiss, V., Manning, E. A., Huang, L. Q. et al., Antibody association with HER-2/neu-targeted vaccine enhances CD8 T cell responses in mice through Fc-mediated activation of DCs. J. Clin. Invest. 2008. 118: 1700-1711.
    • (2008) J. Clin. Invest , vol.118 , pp. 1700-1711
    • Kim, P.S.1    Armstrong, T.D.2    Song, H.3    Wolpoe, M.E.4    Weiss, V.5    Manning, E.A.6    Huang, L.Q.7
  • 40
    • 57149110636 scopus 로고    scopus 로고
    • Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma
    • Saenger, Y. M., Li, Y., Chiou, K. C., Chan, B., Rizzuto, G., Terzulli, S. L., Merghoub, T. et al., Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma. Cancer Res. 2008. 68: 9884-9891.
    • (2008) Cancer Res , vol.68 , pp. 9884-9891
    • Saenger, Y.M.1    Li, Y.2    Chiou, K.C.3    Chan, B.4    Rizzuto, G.5    Terzulli, S.L.6    Merghoub, T.7
  • 41
    • 33846068828 scopus 로고    scopus 로고
    • Autophagy in MHC class II antigen processing
    • Strawbridge, A. B. and Blum, J. S., Autophagy in MHC class II antigen processing. Curr. Opin. Immunol. 2007. 19: 87-92.
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 87-92
    • Strawbridge, A.B.1    Blum, J.S.2
  • 42
    • 0031041233 scopus 로고    scopus 로고
    • Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
    • Bloom, M. B., Perry-Lalley, D., Robbins, P. F., Li, Y., el-Gamil, M., Rosenberg, S. A. and Yang, J. C., Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J. Exp. Med. 1997. 185: 453-459.
    • (1997) J. Exp. Med , vol.185 , pp. 453-459
    • Bloom, M.B.1    Perry-Lalley, D.2    Robbins, P.F.3    Li, Y.4    el-Gamil, M.5    Rosenberg, S.A.6    Yang, J.C.7
  • 44
    • 0013086328 scopus 로고
    • Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope
    • Milich, D. R., Hughes, J. L., McLachlan, A., Thornton, G. B. and Moriarty, A., Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope. Proc. Natl. Acad. Sci. USA 1988. 85: 1610-1614.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1610-1614
    • Milich, D.R.1    Hughes, J.L.2    McLachlan, A.3    Thornton, G.B.4    Moriarty, A.5


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