Studies on the reactivity of (9-methyl-5,6-dihydronaphtho[1′, 2′:4,5]-thieno[2,3-d]pyrimidin-11-yl)hydrazine towards some reagents for biological evaluation

Scientia Pharmaceutica

Volumn 78, Issue 1, 2010, Pages 1-12

  Rashad, Aymn E ^a   Shamroukh, Ahmed H ^a   Abdel Megeid, Randa E ^a   Sayed, Hayam H ^a   Abdel Wahed, Nayera M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antimicrobial activity; C nucleosides; Pyrazole; Pyridazine; Thieno 2,3 d pyrimidine

Indexed keywords

(9 METHYL 5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL)HYDRAZINE; 1 (9 METHYL 5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLE DERIVATIVE; 1,2,3,4,5 PENTA O ACETYL 1 C (5 METHYL 8,9 DIHYDRONAPHTHO[1',2':4,5]THIENO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 2 YL)ARABINITOL; 2 (9 METHYL 5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 6 PHENYL 4,5 DIHYDROPYRIDAZIN 3(2H) ONE; 4,5,6,7 TETRACHLORO 2 [(9 METHYL 5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL)AMINO] 1H ISOINDOLE 1,3(2H) DIONE; C NUCLEOSIDE; CHLORAMPHENICOL; FLUCONAZOLE; GLUCOSE; GLUCOSE (9 METHYL 5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL)HYDRAZONE; HYDRAZINE DERIVATIVE; HYDRAZONE DERIVATIVE; MALONONITRILE; REAGENT; TETRACYANOETHYLENE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BIOLOGICAL MONITORING; CANDIDA ALBICANS; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; INHIBITION KINETICS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 77749240317     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.0910-11     Document Type: Article

References (20)

1. Rashad AE, Mohamed MS, Zaki MEA, Fatahala SS. Synthesis and Biological Evaluation of Some Pyrrolo[2,3-d]pyrimidines. Arch Pharm. 2006; 339, 664-669. doi:10.1002/ardp.200600055
2. Jyh-Haur C, Kak-Shan S, Tsu-An H, Chia-Liang T, Chung-Chi L, Yen-Chun L, Chih-Shiang C, Sung-Nien T, Shin-Ru S. Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: a novel class of potent enterovirus inhibitor. Bioorg Med Chem Lett. 2004; 14: 2519-2525. doi:10.1016/j.bmcl.2004.02.092
3. Dolakova P, Dracinsky M, Masojidkova M, Solinova V, Kasicka V, Holy A. Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines. Eur J Med Chem. 2009; 44: 2408-2424. doi:10.1016/j.ejmech.2008.09.031
4. Baraldi PG, Pavani MG, Nunez MC, Vitali PBB, Gambari R, Romagnoli R. Antimicrobial and antitumor activity of N-heteroimine-1,2,3-diathiazoles and their transformation in triazolo-, imidazo- and pyrazolopyrimidines. Bioorg Med Chem. 2002; 10: 449-456. doi:10.1016/S0968-0896(01)00294-2
5. Nasr MN, Gineinah MM. Pyrido[2,3-d]pyrimidines and pyrimido[5',4':5,6]-pyrido[2,3-d] pyrimidines as new antiviral agents: Synthesis and biological activity. Arch Pharm. 2002; 335: 289-295. doi:10.1002/1521-4184(200208)335:6〈289::AID-ARDP289〉3.0.CO;2-Z
6. Loksha YM, Pedersen EB, Loddo R, Colla P. Synthesis and Anti-HIV-1 Activity of 1-Substiuted 6-(3-Cyanobenzoyl) and [(3-Cyanophenyl)fluoromethyl]-5- ethyluracils. Arch Pharm. 2009; 342: 501-506. doi:10.1002/ardp.200900058
7. Raffa D, Maggio B, Plescia F, Cascioferro S, Raimondi MV, Plescia S, Cusimano MG. Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies. Arch Pharm. 2009; 342: 321-326. doi:10.1002/ardp.200800140
8. Aly AA. Synthesis and pharmacological activity of annelated pyrimidine derivatives. Phosphorus, Sulfur Silicon Relat Elem. 2006; 181:1285-1298. doi:10.1080/10426500500326792
9. Rashed AE, Shamroukh AH, Hegab MI, Awad HM. Synthesis of some biologically active pyrazoles and C-nucleosides. Acta Chim Slov. 2005; 52: 429-434.
10. Rashad AE, Hegab MI, Abdel-Megeid RE, Fatahala NA, Abdel-Megeid FME. Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives. Eur J Med Chem. 2009; 182: 1535-1556. doi:10.1016/j.ejmech.2009.02.012
11. Shamroukh AH, Rashad AE, Sayed HH. Synthesis of some pyrazolo[3,4- d]pyrimidine derivatives for biological evaluation. Phosphorus, Sulfur Silicon Relat Elem. 2005; 180: 2347-2360. doi:10.1080/104265090921074
12. Rashad AE, Hegab MI, Abdel-Megeid RE, Micky JA, Abdel-Megeid FME. Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives. Bioorg Med Chem. 2008; 16: 7102-7106. doi:10.1016/j.bmc.2008.06.054
13. Shamroukh AH, Zaki MEA, Morsy EMH, Abdel-Motti FM, Abdel-Megeid FME. Synthesis of pyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine derivatives for antiviral evaluation. Arch Pharm. 2007; 340: 236-243. doi:10.1002/ardp.200700005
14. Rashad AE, Shamroukh AH, Ali MA, Abdel-Motti FM. Synthesis and antiviral screening of some novel pyridazines and triazolopyridazine nucleosides. Heteroatom Chem. 2007; 18: 274-282. doi:10.1002/hc.20296
15. Hegab MI, Hassan NA, Rashad AE, Fahmy AA, Abdel-Megeid FME. Synthesis, reactions, and antimicrobial activity of some fused thieno[2,3-d] pyrimidine derivatives. Phosphorus, Sulfur Silicon Relat Elem. 2007; 182: 1535-1556. doi:10.1080/10426500701247151
16. Rashad AE, Heikal OA, El-Nezhawy AOH, Abdel-Megeid FME. Synthesis and isomerization of thienotriazolopyrimidine and thienotetrazolo pyrimidine derivatives with potential anti-inflammatory activity. Heteroatom Chem. 2005; 16: 226-234. doi:10.1002/hc.20114
17. Litvinov VP. Thienopyrimidines: synthesis, properties, and biological activity. Russ Chem Bull. 2004; 53: 487-516. doi:10.1023/B:RUCB.0000035630. 75564.2b
18. Abdel-Megeid FME, Hassan NA, Zahran MA, Rashad AE. Synthesis of 5,6-dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidines, 5,6-dihydronaphtho [1',2':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines and some of their nucleosides. Sulfur Lett. 1998; 21: 269-284.
19. Jain SR, Kar A. The antibacterial activity of some essential oils and their combinations. Planta Med. 1971; 20: 118-123. doi:10.1055/s-0028-1099675
20. Scott AC. Laboratory Control of Antimicrobial Therapy. In: Collee JG, Duguid JP, Fraser AG, Marmion BP. Mackie and MacCartney Practical Medical Microbiology. 13th Ed, Churchill Livingstone. 1989; 2: pp. 161-181.