Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2408-2424

  Doláková, Petra ^a   Dračínský, Martin ^a   Masojídková, Milena ^a   Šolínová, Veronika ^a   Kašička, Václav ^a   Holý, Antonín ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acyclic nucleoside phosphonates; Alkylation; Bisphosphonates; Pyrimidine

Indexed keywords

2 (4 METHOXYBENZYL)AMINO 4,6 BIS[2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2 (HEXADECYLOXY)ETHYL 2 AMINO 4 (2 HYDROXYETHOXY) 5 METHYL 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2 (HEXADECYLOXY)ETHYL 2 AMINO 4 (2 HYDROXYETHOXY) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2 (HEXADECYLOXY)ETHYL 2 AMINO 5 BROMO 4 (2 HYDROXYETHOXY) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2 AMINO 4 [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY] 6 [2 (PHOSPHONOMETHOXY)PROPOXY]PYRIMIDINE; 2 AMINO 4 [2 (PHOSPHONOMETHOXY)ETHOXY] 6 [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 2 AMINO 4 [2 (PHOSPHONOMETHOXY)ETHOXY] 6 [2 (PHOSPHONOMETHOXY)PROPOXY] PYRIMIDINE; 2 AMINO 4 [[2 (PHOSPHONOMETHOXY)ETHYL]SULFANYL] 6 [[2 (PHOSPHONOMETHOXY)PROPYL] SULFANYL]PYRIMIDINE; 2 AMINO 4 [[2 (PHOSPHONOMETHOXY)ETHYL]SULFANYL] 6 [[2 (PHOSPHONOMETHOXY)PROPYL]SULFANYL] PYRIMIDINE; 2 AMINO 4 BIS[[2 (PHOSPHONOMETHOXY)PROPYL]SULFANYL]PYRIMIDINE; 2 AMINO 4,6 BIS[(PHOSPHONOMETHOXY)ALKOXY]PYRIMIDINE; 2 AMINO 4,6 BIS[(PHOSPHONOMETHOXY)ALKOXY]PYRIMIDINE DERIVATIVE; 2 AMINO 4,6 BIS[2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 2 AMINO 4,6 BIS[2 (PHOSPHONOMETHOXY) PROPOXY]PYRIMIDINE; 2 AMINO 4,6 BIS[2 (PHOSPHONOMETHOXY)PROPOXY]PYRIMIDINE; 2 AMINO 4,6 BIS[[2 (PHOSPHONOMETHOXY)ETHYL]SULFANYL]PYRIMIDINE; 2 AMINO 4,6 BIS[[2 (PHOSPHONOMETHOXY)PROPYL]SULFANYL]PYRIMIDINE; 2 BENZYLAMINO 4,6 BIS[2 (PHOSPHONOMETHOXY) ETHOXY]PYRIMIDINE; 2 CYCLOPENTYLAMINO 4,6 BIS[2 (PHOSPHONOMETHOXY) ETHOXY]PYRIMIDINE; 2 CYCLOPROPYLAMINO 4,6 BIS[2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2 METHYLAMINO 4,6 BIS[2 (PHOSPHONOMETHOXY) ETHOXY]PYRIMIDINE; 2 MORPHOLINO 4,6 BIS[2-(PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 4,6 BIS[2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; BISPHOSPHONIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; NONHUMAN;

ALKYLATION; ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DIPHOSPHONATES; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, CAPILLARY; HELA CELLS; HL-60 CELLS; HUMANS; MICE; MOLECULAR STRUCTURE; NUCLEOSIDES; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64249094188     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.031     Document Type: Article

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