Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3285-3292

  Rashad, Aymn E ^a   Hegab, Mohamed I ^a   Abdel Megeid, Randa E ^a   Fathalla, Nahed ^b   Abdel Megeid, Farouk M E ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b AL AZHAR UNIVERSITY   (Egypt)

Author keywords

Antiviral evaluation; C nucleosides; Pyrazoles; Pyrazolopyrimidines; Synthesis

Indexed keywords

1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YLAMINE; 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YLHYDRAZINE; 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4(3H) ONE; 1,2,3,4 TETRA O ACETYL 1 C 1 (5,6 DIHYDRONAPHTHO [1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) PYRAZOLO[4,3 E][1,2,4]TRIAZOLO 1,5 C]PYRIMIDIN 2 YL DEXTRO ERYTHRITOL; 1,2,3,4,5 PENTA O ACETYL 1 C 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 2 YL DEXTRO ARABINITOLE; 2,3,4,5 TETRA O ACETYL DEXTRO RIBOSE N 1 (5,6 DIHYDRONAPHTHO [1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YL HYDRAZONE; 2,3,4,5,6 PENTA O ACETYL DEXTRO GLUCOSE N 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YL HYDRAZONE; 4 IMINO 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1,4 DIHYDROPYRAZOLO[3,4 D]PYRIMIDIN 5 YLAMINE; 6 METHYL 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4(3H)ONE; ACICLOVIR; ETHYL 4 CYANO 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO [2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOL 5 YL IMIDOFORMATE; GLUCOSE N 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YL HYDRAZONE; HYDRAZONE DERIVATIVE; N [4 CYANO 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOL 5 YL]ACETAMIDE; N [4 CYANO 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOL 5 YL]FORMAMIDE; N [4 CYANO 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOL 5 YL]FORMAMIDINE; PYRAZOLE DERIVATIVE; PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVE; PYRAZOLOPYRIMIDINE DERIVATIVE; RIBOSE N 1 (5,6 DIHYDRONAPHTHO[1',2':4,5]THIENO[2,3 D]PYRIMIDIN 11 YL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YL HYDRAZONE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BIOASSAY; CELL STRAIN HEPG2; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; VERO CELL; VIRUS INFECTIVITY; VIRUS PLAQUE;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; HERPESVIRUS 1, HUMAN; HUMANS; PYRAZOLES; PYRIMIDINES;

EID: 67349102739     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.02.012     Document Type: Article

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