2009: Signaling breakthroughs of the year

Science Signaling

Volumn 3, Issue 103, 2010, Pages

  Adler, Elizabeth M ^a  

^a AAAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSCISIC ACID; CYCLIN DEPENDENT KINASE 1; EPHRIN RECEPTOR B2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL POLYPHOSPHATE 4 PHOSPHATASE TYPE II; INTERLEUKIN 17; INTERLEUKIN 22; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE SYK; PROTEIN SH2; RAC1 PROTEIN; RHODOPSIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR FOXO; TYROSINE; UNCLASSIFIED DRUG;

AGING; CANCER CELL; DENDRITIC CELL; DROSOPHILA; ENVIRONMENTAL STRESS; EPITHELIUM CELL; GENE EXPRESSION; HELPER CELL; HIPPOCAMPUS; HUMAN; IMMUNE SYSTEM; LEARNING; LUNG CANCER; MEMORY; NEUROSCIENCE; NOISE REDUCTION; NONHUMAN; ONCOGENE K RAS; PRIMATE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; REVIEW; RNA INTERFERENCE; SCHIZOPHRENIA; TRANSGENICS; ANIMAL; DISEASE MODEL; EDITORIAL; GENETICS; HISTORY; MEDICAL RESEARCH; METABOLISM; PLANT; SIGNAL TRANSDUCTION;

MAMMALIA; PRIMATES;

AGING; ANIMALS; BIOMEDICAL RESEARCH; DISEASE MODELS, ANIMAL; HISTORY, 21ST CENTURY; HUMANS; MEMORY; PLANTS; PRIMATES; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 77649290650     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3103eg1     Document Type: Review

References (47)

1. D. A. Barbie, P. Tamayo, J. S. Boehm, S. Y. Kim, S. E. Moody, I. F. Dunn, A. C. Schinzel, P. Sandy, E. Meylan, C. Scholl, S. Fröhling, E. M. Chan, M. L. Sos, K. Michel, C. Mermel, S. J. Silver, B. A. Weir, J. H. Reiling, Q. Sheng, P. B. Gupta, R. C. Wad-low, H. Le, S. Hoersch, B. S. Wittner, S. Ra-maswamy, D. M. Livingston, D. M. Sabatini, M. Meyerson, R. K. Thomas, E. S. Lander, J. P. Mesirov, D. E. Root, D. G. Gilliland, T. Jacks, W. C. Hahn, Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462, 108-112 (2009).
2. J. Luo, M. J. Emanuele, D. Li, C. J. Creighton, M. R. Schlabach, T. F. Westbrook, K. K. Wong, S. J. Elledge, A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848 (2009).
3. E. Meylan, A. L. Dooley, D. M. Feldser, L. Shen, E. Turk, C. Ouyang, T. Jacks, Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462, 104-107 (2009).
4. A. Singh, P. Greninger, D. Rhodes, L. Koopman, S. Violette, N. Bardeesy, J. A. Settleman, A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell 15, 489-500 (2009).
5. C. Scholl, S. Fröhling, I. F. Dunn, A. C. Schinzel, D. A. Barbie, S. Y. Kim, S. J. Silver, P. Tamayo, R. C. Wadlow, S. Ramaswamy, K. Döhner, L. Bullinger, P. Sandy, J. S. Boehm, D. E. Root, T. Jacks, W. C. Hahn, D. G. Gilliland, Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137, 821-834 (2009).
6. J. Downward, Cancer: A tumour gene's fatal flaws. Nature 462, 44-45 (2009).
7. J. T. Chang, C. Carvalho, S. Mori, A. H. Bild, M. L. Gatza, Q. Wang, J. E. Lucas, A. Potti, P. G. Febbo, M. West, J. R. Nevins, A genomic strategy to elucidate modules of oncogenic pathway signaling networks. Mol. Cell 34, 104-114 (2009).
8. I. Amit, M. Garber, N. Chevrier, A. P. Leite, Y. Don-ner, T. Eisenhaure, M. Guttman, J. K. Grenier, W. Li, O. Zuk, L. A. Schubert, B. Birditt, T. Shay, A. Goren, X. Zhang, Z. Smith, R. Deering, R. C. Mc-Donald, M. Cabili, B. E. Bernstein, J. L. Rinn, A. Meissner, D. E. Root, N. Hacohen, A. Regev, Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science 326, 257-263 (2009).
9. B. Schoeberl, E. A. Pace, J. B. Fitzgerald, B. D. Harms, L. Xu, L. Nie, B. Linggi, A. Kalra, V. Para-gas, R. Bukhalid, V. Grantcharova, N. Kohli, K. A. West, M. Leszczyniecka, M. J. Feldhaus, A. J. Kud-la, U. B. Nielsen, Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci. Signal. 2, ra31 (2009).
10. C. Jørgensen, A. Sherman, G. I. Chen, A. Pas-culescu, A. Poliakov, M. Hsiung, B. Larsen, D. G. Wilkinson, R. Linding, T. Pawson, Cell-specific information processing in segregating populations of Eph receptor-ephrin- expressing cells. Science 326, 1502-1509 (2009).
11. J. L. Mummery-Widmer, M. Yamazaki, T. Stoeger, M. Novatchkova, S. Bhalerao, D. Chen, G. Dietzl, B. J. Dickson, J. A. Knoblich, Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458, 987-992 (2009).
12. C. Choudhary, C. Kumar, F. Gnad, M. L. Nielsen, M. Rehman, T. C. Walther, J. V. Olsen, M. Mann, Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-840 (2009).
13. L. J. Holt, B. B. Tuch, J. Villén, A. D. Johnson, S. P. Gygi, D. O. Morgan, Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325, 1682-1686 (2009).
14. V. Mayya, D. H. Lundgren, S.-I. Hwang, K. Rezaul, L. Wu, J. K. Eng, V. Rodionov, D. K. Han, Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. 2, ra46 (2009).
15. J. D. Humphries, A. Byron, M. D. Bass, S. E. Craig, J. W. Pinney, D. Knight, M. J. Humphries, Pro-teomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci. Signal. 2, ra51 (2009).
16. C. S. H. Tan, B. Bodenmiller, A. Pasculescu, M. Jovanovic, M. O. Hengartner, C. Jørgensen, G. D. Bader, R. Aebersold, T. Pawson, R. Linding, Com-parative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci. Signal. 2, ra39 (2009).
17. C. S. H. Tan, A. Pasculescu, W. A. Lim, T. Pawson, G. D. Bader, R. Linding, Positive selection of tyrosine loss in metazoan evolution. Science 325, 1686-1688 (2009).
18. W. L. Yang, J. Wang, C. H. Chan, S. W. Lee, A. D. Campos, B. Lamothe, L. Hur, B. C. Grabiner, X. Lin, B. G. Darnay, H. K. Lin, The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325, 1134-1138 (2009).
19. B. Fine, C. Hodakoski, S. Koujak, T. Su, L. H. Saal, M. Maurer, B. Hopkins, M. Keniry, M. L. Sulis, S. Mense, H. Hibshoosh, R. Parsons, Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325, 1261-1265 (2009).
20. C. Gewinner, Z. C. Wang, A. Richardson, J. Teruya-Feldstein, D. Etemadmoghadam, D. Bowtell, J. Barretina, W. M. Lin, L. Rameh, L. Salmena, P. P. Pandolfi, L. C. Cantley, Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16, 115-125 (2009).
21. L. Srinivasan, Y. Sasaki, D. P. Calado, B. Zhang, J. H. Paik, R. A. DePinho, J. L. Kutok, J. F. Kearney, K. L. Otipoby, K. Rajewsky, PI3 kinase signals BCR-dependent mature B cell survival. Cell 139, 573-586 (2009).
22. D. E. Harrison, R. Strong, Z. D. Sharp, J. F. Nel-son, C. M. Astle, K. Flurkey, N. L. Nadon, J. E. Wilkinson, K. Frenkel, C. S. Carter, M. Pahor, M. A. Javors, E. Fernandez, R. A. Miller, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009).
23. C. Chen, Y. Liu, Y. Liu, P. Zheng, mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2, ra75 (2009).
24. C. Selman, J. M. Tullet, D. Wieser, E. Irvine, S. J. Lingard, A. I. Choudhury, M. Claret, H. Al-Qassab, D. Carmignac, F. Ramadani, A. Woods, I. C. Robinson, E. Schuster, R. L. Batterham, S. C. Kozma, G. Thomas, D. Carling, K. Okkenhaug, J. M. Thornton, L. Partridge, D. Gems, D. J. Withers, Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140-144 (2009).
25. B. M. Zid, A. N. Rogers, S. D. Katewa, M. A. Var-gas, M. C. Kolipinski, T. A. Lu, S. Benzer, P. Ka-pahi, 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139, 149-160 (2009).
26. N. Y. Kalaany, D. M. Sabatini, Tumours with PI3K activation are resistant to dietary restriction. Nature 458, 725-731 (2009).
27. J. Y. Kim, X. Duan, C. Y. Liu, M. H. Jang, J. U. Guo, N. Pow-anpongkul, E. Kang, H. Song, G. L. Ming, DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63, 761-773 (2009).
28. M. R. Pagani, K. Oishi, B. D. Gelb, Y. Zhong, The phosphatase SHP2 regulates the spacing effect for long-term memory induction. Cell 139, 186-198 (2009).
29. S. A. van de Pavert, B. J. Olivier, G. Goverse, M. F. Vondenhoff, M. Greuter, P. Beke, K. Kusser, U. E. Höpken, M. Lipp, K. Niederreither, R. Blomhoff, K. Sitnik, W. W. Agace, T. D. Randall, W. J. de Jonge, R. E. Mebius, Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat. Immunol. 10, 1193-1199 (2009).
30. I. I. Ivanov, K. Atarashi, N. Manel, E. L. Brodie, T. Shima, U. Karaoz, D. Wei, K. C. Goldfarb, C. A. Santee, S. V. Lynch, T. Tanoue, A. Imaoka, K. Itoh, K. Takeda, Y. Umesaki, K. Honda, D. R. Littman, Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
31. Y. Ma, I. Szostkiewicz, A. Korte, D. Moes, Y. Yang, A. Christmann, E. Grill, Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science 324, 1064-1068 (2009).
32. S. Y. Park, P. Fung, N. Nishimura, D. R. Jensen, H. Fujii, Y. Zhao, S. Lumba, J. Santiago, A. Ro-drigues, T. F. Chow, S. E. Alfred, D. Bonetta, R. Finkelstein, N. J. Provart, D. Desveaux, P. L. Ro-driguez, P. McCourt, J. K. Zhu, J. I. Schroeder, B. F. Volkman, S. R. Cutler, Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science 324, 1068-1071 (2009).
33. H. Fujii, V. Chinnusamy, A. Rodrigues, S. Rubio, R. Antoni, S.-Y. Park, S. R. Cutler, J. Sheen, P. L. Rodriguez, J.-K. Zhu, In vitro reconstitution of an abscisic acid signalling pathway. Nature 462, 660-664 (2009).
34. K. Melcher, L.-M. Ng, X. E. Zhou, F.-F. Soon, Y. Xu, K. M. Suino-Powell, S.-Y. Park, J. J. Weiner, H. Fu-jii, V. Chinnusamy, A. Kovach, J. Li, Y. Wang, J. Li, F. C. Peterson, D. R. Jensen, E.-L. Yong, B. F. Volk-man, S. R. Cutler, J.-K. Zhu, H. E. Xu, A gate-latchlock mechanism for hormone signalling by abscisic acid receptors. Nature 462, 602-608 (2009).
35. K. I. Miyazono, T. Miyakawa, Y. Sawano, K. Kubo-ta, H.-J. Kang, A. Asano, Y. Miyauchi, M. Taka-hashi, Y. Zhi, Y. Fujita, T. Yoshida, K.-S. Kodaira, K. Yamaguchi-Shinozaki, M. Tanokura, Structural basis of abscisic acid signalling. Nature 462, 609-614 (2009).
36. N. Nishimura, K. Hitomi, A. S. Arvai, R. P. Rambo, C. Hitomi, S. R. Cutler, J. I. Schroeder, E. D. Get-zoff, Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326, 1373-1379 (2009).
37. J. Santiago, F. Dupeux, A. Round, R. Antoni, S.-Y. Park, M. Jamin, S. R. Cutler, P. L. Rodriguez, J. A. Márquez, The abscisic acid receptor PYR1 in complex with abscisic acid. Nature 462, 665-668 (2009).
38. P. Yin, H. Fan, Q. Hao, X. Yuan, D. Wu, Y. Pang, C. Yan, W. Li, J. Wang, N. Yan, Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat. Struct. Mol. Biol. 16, 1230-1236 (2009).
39. E. Pennisi, Plant biology. Stressed out over a stress hormone. Science 324, 1012-1013 (2009).
40. M. R. Sussman, G. N. Phillips Jr., Plant science. How plant cells go to sleep for a long, long time. Science 326, 1356-1357 (2009).
41. L. B. Sheard, N. Zheng, Plant biology: Signal advance for abscisic acid. Nature 462, 575-576 (2009).
42. R. D. Airan, K. R. Thompson, L. E. Fenno, H. Bernstein, K. Deisseroth, Temporally precise in vivo control of intracellular signalling. Nature 458, 1025-1029 (2009).
43. A. Levskaya, O. D. Weiner, W. A. Lim, C. A. Voigt, Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 461, 997-1001 (2009).
44. Y. I. Wu, D. Frey, O. I. Lungu, A. Jaehrig, I. Schlichting, B. Kuhlman, K. M. Hahn, A genetically encoded photoactivatable Rac controls the motility of living cells. Nature 461, 104-108 (2009).
45. E. Sasaki, H. Suemizu, A. Shimada, K. Hanaza-wa, R. Oiwa, M. Kamioka, I. Tomioka, Y. So-tomaru, R. Hirakawa, T. Eto, S. Shiozawa, T. Mae-da, M. Ito, R. Ito, C. Kito, C. Yagihashi, K. Kawai, H. Miyoshi, Y. Tanioka, N. Tamaoki, S. Habu, H. Okano, T. Nomura, Generation of transgenic nonhuman primates with germline transmission. Nature 459, 523-527 (2009).
46. A. S. Shah, Y. Ben-Shahar, T. O. Moninger, J. N. Kline, M. J. Welsh, Motile cilia of human airway epithelia are chemosensory. Science 325, 1131-1134 (2009).
47. S. C. Kinnamon, S. D. Reynolds, Cell biology. Using taste to clear the air (ways). Science 325, 1081-1082 (2009).