메뉴 건너뛰기




Volumn 39, Issue 2, 2010, Pages 237-242

Leflunomide: Is a new oral agent in treatment of acute pancreatitis?

Author keywords

Leflunomide; Pancreatitis; Rat; Taurocholate

Indexed keywords

AMYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEFLUNOMIDE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE;

EID: 77649246747     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181bab6a9     Document Type: Article
Times cited : (4)

References (49)
  • 1
    • 0029014731 scopus 로고
    • Current views on the pathophysiology of acute biliary pancreatitis
    • Banerjee AK, Steele RJ. Current views on the pathophysiology of acute biliary pancreatitis. Gut. 1995;36:803-805.
    • (1995) Gut , vol.36 , pp. 803-805
    • Banerjee, A.K.1    Steele, R.J.2
  • 3
    • 0032985879 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-JB activation improves the survival of rats with taurocholate pancreatitis
    • Satoh A, Shimosegawa T, Fujita M, et al. Inhibition of nuclear factor-JB activation improves the survival of rats with taurocholate pancreatitis. Gut. 1999;44:253-258.
    • (1999) Gut , vol.44 , pp. 253-258
    • Satoh, A.1    Shimosegawa, T.2    Fujita, M.3
  • 4
    • 0036436837 scopus 로고    scopus 로고
    • Acute experimental pancreatitis and NFJB/Rel activation
    • Algul H, Tando Y, Schneider G, et al. Acute experimental pancreatitis and NFJB/Rel activation. Pancreatology. 2002;2:503-509.
    • (2002) Pancreatology , vol.2 , pp. 503-509
    • Algul, H.1    Tando, Y.2    Schneider, G.3
  • 5
    • 0034967604 scopus 로고    scopus 로고
    • Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis
    • Frossard JL, Pastor CM, Hadengue A. Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2001;280:1157-1162.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280 , pp. 1157-1162
    • Frossard, J.L.1    Pastor, C.M.2    Hadengue, A.3
  • 6
    • 0033866838 scopus 로고    scopus 로고
    • Pancreatic elastase activates pulmonary nuclear factor J B and inhibitory J B, mimicking pancreatitis-associated adult respiratory distress syndrome
    • Jaffray C, Yang J, Carter G, et al. Pancreatic elastase activates pulmonary nuclear factor J B and inhibitory J B, mimicking pancreatitis- associated adult respiratory distress syndrome. Surgery. 2000;128:225-231.
    • (2000) Surgery , vol.128 , pp. 225-231
    • Jaffray, C.1    Yang, J.2    Carter, G.3
  • 7
    • 38549084647 scopus 로고    scopus 로고
    • The role of NF-JB activation in the pathogenesis of acute pancreatitis
    • Rakonczay Z Jr, Hegyi P, Takács T, et al. The role of NF-JB activation in the pathogenesis of acute pancreatitis. Gut. 2008;57:259-267.
    • (2008) Gut , vol.57 , pp. 259-267
    • Rakonczay Jr., Z.1    Hegyi, P.2    Takács, T.3
  • 8
    • 0031183766 scopus 로고    scopus 로고
    • The role of nuclear factor J B in cytokine gene regulation
    • Blackwell TS, Christman JW. The role of nuclear factor J B in cytokine gene regulation. Am J Respir Cell Mol Biol. 1997;17:3-9.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 3-9
    • Blackwell, T.S.1    Christman, J.W.2
  • 9
    • 23144465846 scopus 로고    scopus 로고
    • Nuclear factor-JB activation on the reactive oxygen species in acute necrotizing pancreatitic rats
    • Long J, Song N, Liu XP, et al. Nuclear factor-JB activation on the reactive oxygen species in acute necrotizing pancreatitic rats. World J Gastroenterol. 2005;11:4277-4280.
    • (2005) World J Gastroenterol , vol.11 , pp. 4277-4280
    • Long, J.1    Song, N.2    Liu, X.P.3
  • 10
    • 0028792355 scopus 로고
    • Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis
    • Mladenovic V, Domljan Z, Rozman B, et al. Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Arthritis Rheum. 1995;38:1595-1603.
    • (1995) Arthritis Rheum , vol.38 , pp. 1595-1603
    • Mladenovic, V.1    Domljan, Z.2    Rozman, B.3
  • 11
    • 0030987746 scopus 로고    scopus 로고
    • Leflunomide and malononitrilamides
    • Silva Júnior H, Morris RE. Leflunomide and malononitrilamides. Am J Med Sci. 1997;313:289-301.
    • (1997) Am J Med Sci , vol.313 , pp. 289-301
    • Silva Júnior, H.1    Morris, R.E.2
  • 12
    • 0032773737 scopus 로고    scopus 로고
    • A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner
    • Hamilton LC, Vojnovic I, Warner TD. A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner. Br J Pharmacol. 1999;127:1589-1596.
    • (1999) Br J Pharmacol , vol.127 , pp. 1589-1596
    • Hamilton, L.C.1    Vojnovic, I.2    Warner, T.D.3
  • 13
    • 0033557695 scopus 로고    scopus 로고
    • Immunosuppressive leflunomide metabolite ( A77 1726) blocks TNF-dependent nuclear factor-JB activation and gene expression
    • Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-JB activation and gene expression. J Immunol. 1999;162:2095-2102.
    • (1999) J Immunol , vol.162 , pp. 2095-2102
    • Manna, S.K.1    Aggarwal, B.B.2
  • 14
    • 0034004844 scopus 로고    scopus 로고
    • Frequency and time course of pancreatic and extra pancreatic bacterial infection in experimental acute pancreatitis in rats
    • Schwarz M, Thomsen J, Meyer H, et al. Frequency and time course of pancreatic and extra pancreatic bacterial infection in experimental acute pancreatitis in rats. Surgery. 2000;127:427-432.
    • (2000) Surgery , vol.127 , pp. 427-432
    • Schwarz, M.1    Thomsen, J.2    Meyer, H.3
  • 15
    • 33646453495 scopus 로고    scopus 로고
    • Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver
    • Karaman A, Fadillioglu E, Turkmen E, et al. Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. Pediatr Surg Int. 2006;22:428-434.
    • (2006) Pediatr Surg Int , vol.22 , pp. 428-434
    • Karaman, A.1    Fadillioglu, E.2    Turkmen, E.3
  • 16
    • 0033565880 scopus 로고    scopus 로고
    • Vivo activity of leflunomide: Pharmacokinetic analyses and mechanism of immunosuppression
    • Chong AS, Huang W, Liu W, et al. In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression. Transplantation. 1999;68:100-109.
    • (1999) Transplantation , vol.68 , pp. 100-109
    • Chong, A.S.1    Huang, W.2    Liu, W.3
  • 17
    • 48549101190 scopus 로고    scopus 로고
    • Does leflunomide attenuate the sepsis-induced acute lung injury?
    • Ozturk E, Demirbilek S, Begec Z, et al. Does leflunomide attenuate the sepsis-induced acute lung injury? Pediatr Surg Int. 2008;24: 899-905.
    • (2008) Pediatr Surg Int , vol.24 , pp. 899-905
    • Ozturk, E.1    Demirbilek, S.2    Begec, Z.3
  • 18
    • 0024321860 scopus 로고
    • Effect temporary ischemia upon development and histological patterns of acute pancreatitis in the rat
    • Spormann H, Sokolowski A, Letko G. Effect temporary ischemia upon development and histological patterns of acute pancreatitis in the rat. Path Res Pract. 1989;184:507-513.
    • (1989) Path Res Pract , vol.184 , pp. 507-513
    • Spormann, H.1    Sokolowski, A.2    Letko, G.3
  • 19
    • 0027162506 scopus 로고
    • Prevalence and prediction of multiple organ system failure and mortality in acute pancreatitis
    • Tran DD, Cuesta MA, Schneider AJ, et al. Prevalence and prediction of multiple organ system failure and mortality in acute pancreatitis. J Crit Care. 1993;8(3):145-153.
    • (1993) J Crit Care , vol.8 , Issue.3 , pp. 145-153
    • Tran, D.D.1    Cuesta, M.A.2    Schneider, A.J.3
  • 20
    • 0034112740 scopus 로고    scopus 로고
    • Acute lung injury in two experimental models of acute pancreatitis: Infusion of saline or sodium taurocholate into the pancreatic duct
    • Lichtenstein A, Milani R, Fernezlian SM, et al. Acute lung injury in two experimental models of acute pancreatitis: infusion of saline or sodium taurocholate into the pancreatic duct. Crit Care Med. 2000;28(5):1497-1502.
    • (2000) Crit Care Med , vol.28 , Issue.5 , pp. 1497-1502
    • Lichtenstein, A.1    Milani, R.2    Fernezlian, S.M.3
  • 21
    • 0030098221 scopus 로고    scopus 로고
    • Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay
    • Kuebler WM, Abels C, Schuerer L, et al. Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc Clin Exp. 1996;16:89-97.
    • (1996) Int J Microcirc Clin Exp , vol.16 , pp. 89-97
    • Kuebler, W.M.1    Abels, C.2    Schuerer, L.3
  • 22
    • 0025127633 scopus 로고
    • Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
    • Packer L, Glazer AN, eds. Methods in Enzymology. New York, NY: Academic
    • Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. In: Packer L, Glazer AN, eds. Methods in Enzymology, vol 186. Oxygen Radicals in Biological Systems. New York, NY: Academic; 1990: 407-421.
    • (1990) Oxygen Radicals in Biological Systems , vol.186 , pp. 407-421
    • Esterbauer, H.1    Cheeseman, K.H.2
  • 24
    • 0042200541 scopus 로고    scopus 로고
    • Experimental model of acute pancreatitis in Wistar rat: Glucocorticoid treatment profile
    • Cosen-Binker LI, Binker MG, Negri G, et al. Experimental model of acute pancreatitis in Wistar rat: glucocorticoid treatment profile. Dig Dis Sci. 2003;48(8):1453-1464.
    • (2003) Dig Dis Sci , vol.48 , Issue.8 , pp. 1453-1464
    • Cosen-Binker, L.I.1    Binker, M.G.2    Negri, G.3
  • 25
    • 33645083973 scopus 로고    scopus 로고
    • Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo
    • Chao KC, Chao KF, Chuang CC, et al. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo. Br J Surg. 2006;93(3):332-338.
    • (2006) Br J Surg , vol.93 , Issue.3 , pp. 332-338
    • Chao, K.C.1    Chao, K.F.2    Chuang, C.C.3
  • 26
    • 1842453048 scopus 로고    scopus 로고
    • Infliximab: A new therapeutic agent in acute pancreatitis?
    • Oruc N, Ozutemiz AO, Yukselen V, et al. Infliximab: a new therapeutic agent in acute pancreatitis? Pancreas. 2004;28(1):e1-e8.
    • (2004) Pancreas , vol.28 , Issue.1
    • Oruc, N.1    Ozutemiz, A.O.2    Yukselen, V.3
  • 27
    • 34250833401 scopus 로고    scopus 로고
    • Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways
    • Cao Y, Adhikari S, Clément MV, et al. Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. Am J Pathol. 2007;170(5):1521-1534.
    • (2007) Am J Pathol , vol.170 , Issue.5 , pp. 1521-1534
    • Cao, Y.1    Adhikari, S.2    Clément, M.V.3
  • 28
    • 0032246276 scopus 로고    scopus 로고
    • Early NF-JB activation is associated with hormone-induced pancreatitis
    • Gukovsky I, Gukovskaya AS, Blinman TA, et al. Early NF-JB activation is associated with hormone-induced pancreatitis. Am J Physiol. 1998;275:1402-1414.
    • (1998) Am J Physiol , vol.275 , pp. 1402-1414
    • Gukovsky, I.1    Gukovskaya, A.S.2    Blinman, T.A.3
  • 29
    • 0034974849 scopus 로고    scopus 로고
    • Localized pancreatic NFJB activation and inflammatory response in taurocholate-induced pancreatitis
    • Vaquero E, Gukovsky I, Zaninovic V, et al. Localized pancreatic NFJB activation and inflammatory response in taurocholate-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2001; 280:1197-1208.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280 , pp. 1197-1208
    • Vaquero, E.1    Gukovsky, I.2    Zaninovic, V.3
  • 30
    • 0030730967 scopus 로고    scopus 로고
    • Therapeutic modification of nuclear factor J B binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis
    • Dunn JA, Li C, Ha T, et al. Therapeutic modification of nuclear factor J B binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis. Am Surg. 1997;63: 1036-1043.
    • (1997) Am Surg , vol.63 , pp. 1036-1043
    • Dunn, J.A.1    Li, C.2    Ha, T.3
  • 31
    • 0035746585 scopus 로고    scopus 로고
    • Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis
    • Telek G, Ducroc R, Scoazec JY, et al. Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis. J Surg Res. 2001;96:56-67.
    • (2001) J Surg Res , vol.96 , pp. 56-67
    • Telek, G.1    Ducroc, R.2    Scoazec, J.Y.3
  • 32
    • 9144220803 scopus 로고    scopus 로고
    • Attenuated cerulean induced pancreatitis in nuclear factor-JBYdeficient mice
    • Altavilla D, Famulari C, Passaniti M, et al. Attenuated cerulean induced pancreatitis in nuclear factor-JBYdeficient mice. Lab Invest. 2003;83: 1723-1732.
    • (2003) Lab Invest , vol.83 , pp. 1723-1732
    • Altavilla, D.1    Famulari, C.2    Passaniti, M.3
  • 33
    • 18144363228 scopus 로고    scopus 로고
    • Kinetic study of TNF > production and its regulatory mechanisms in acinar cells during acute pancreatitis induced by bile-pancreatic duct obstruction
    • Ramudo L, Manso MA, Sevillano S, et al. Kinetic study of TNF > production and its regulatory mechanisms in acinar cells during acute pancreatitis induced by bile-pancreatic duct obstruction. J Pathol. 2005;206:9-16.
    • (2005) J Pathol , vol.206 , pp. 9-16
    • Ramudo, L.1    Manso, M.A.2    Sevillano, S.3
  • 34
    • 12444286737 scopus 로고    scopus 로고
    • Role of nuclear factor-JB, reactive oxygen species and cellular signaling in the early phase of acute pancreatitis
    • Shi C, Zhao X, Wang X, et al. Role of nuclear factor-JB, reactive oxygen species and cellular signaling in the early phase of acute pancreatitis. Scand J Gastroenterol. 2005;40:103-108.
    • (2005) Scand J Gastroenterol , vol.40 , pp. 103-108
    • Shi, C.1    Zhao, X.2    Wang, X.3
  • 35
    • 0036083066 scopus 로고    scopus 로고
    • Leflunomide for the treatment of rheumatoid arthritis and autoimmunity
    • Sanders S, Harisdangkul V. Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. Am J Med Sci. 2002;323: 190-193.
    • (2002) Am J Med Sci , vol.323 , pp. 190-193
    • Sanders, S.1    Harisdangkul, V.2
  • 36
    • 0038657686 scopus 로고    scopus 로고
    • Leflunomide for the treatment of rheumatoid arthritis: A systematic review and metaanalysis
    • Osiri M, Shea B, Robinson V, et al. Leflunomide for the treatment of rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol. 2003;30:1182-1190.
    • (2003) J Rheumatol , vol.30 , pp. 1182-1190
    • Osiri, M.1    Shea, B.2    Robinson, V.3
  • 37
    • 0037083864 scopus 로고    scopus 로고
    • Experiences with leflunomide in solid organ transplantation
    • Williams JW, Mital D, Chong A, et al. Experiences with leflunomide in solid organ transplantation. Transplantation. 2002;73:358-366.
    • (2002) Transplantation , vol.73 , pp. 358-366
    • Williams, J.W.1    Mital, D.2    Chong, A.3
  • 38
    • 0038115119 scopus 로고    scopus 로고
    • Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy
    • Prajapati DN, Knox JF, Emmons J, et al. Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. J Clin Gastroenterol. 2003;37:125-128.
    • (2003) J Clin Gastroenterol , vol.37 , pp. 125-128
    • Prajapati, D.N.1    Knox, J.F.2    Emmons, J.3
  • 39
    • 0034122123 scopus 로고    scopus 로고
    • Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
    • Herrmann ML, Schleyerbach R, Kirschbaum BJ. Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology. 2000;47:273-289.
    • (2000) Immunopharmacology , vol.47 , pp. 273-289
    • Herrmann, M.L.1    Schleyerbach, R.2    Kirschbaum, B.J.3
  • 40
    • 0033764113 scopus 로고    scopus 로고
    • Leflunomide: Mode of action in the treatment of rheumatoid arthritis
    • Breedveld FC, Dayer JM. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2000;59:841-849.
    • (2000) Ann Rheum Dis , vol.59 , pp. 841-849
    • Breedveld, F.C.1    Dayer, J.M.2
  • 41
    • 0036023608 scopus 로고    scopus 로고
    • Dynamic effects of leflunomide on IL-1 IL-6 and TNF-> activity produced from peritoneal macrophages in adjuvant arthritis rats
    • Li WD, Ran GX, Teng HL, et al. Dynamic effects of leflunomide on IL-1, IL-6, and TNF-> activity produced from peritoneal macrophages in adjuvant arthritis rats. Acta Pharmacol Sin. 2002;23:752-756.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 752-756
    • Li, W.D.1    Ran, G.X.2    Teng, H.L.3
  • 42
    • 0034670031 scopus 로고    scopus 로고
    • Leflunomide suppresses TNF-induced cellular responses: Effects on NF-J B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis
    • Manna SK, Mukhopadhyay A, Aggarwal BB. Leflunomide suppresses TNF-induced cellular responses: effects on NF-J B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000;165:5962-5969.
    • (2000) J Immunol , vol.165 , pp. 5962-5969
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 43
    • 7044261012 scopus 로고    scopus 로고
    • Leflunomide protects from T cell mediated liver injury in mice through inhibition of nuclear factor-JB
    • Imose M, Nagaki M, Kimura K, et al. Leflunomide protects from T cell mediated liver injury in mice through inhibition of nuclear factor-JB. Hepatology. 2004;40:1160-1169.
    • (2004) Hepatology , vol.40 , pp. 1160-1169
    • Imose, M.1    Nagaki, M.2    Kimura, K.3
  • 45
    • 17044422072 scopus 로고    scopus 로고
    • Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis
    • Reddy SV, Wanchu A, Khullar M, et al. Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis. Int Immunopharmacol. 2005;5(6):1085-1090.
    • (2005) Int Immunopharmacol , vol.5 , Issue.6 , pp. 1085-1090
    • Reddy, S.V.1    Wanchu, A.2    Khullar, M.3
  • 46
    • 0032590082 scopus 로고    scopus 로고
    • NF-JB/Rel activation in cerulean pancreatitis
    • Steinle AU, Weidenbach H, Wagner M, et al. NF-JB/Rel activation in cerulean pancreatitis. Gastroenterology. 1999;116:420-430.
    • (1999) Gastroenterology , vol.116 , pp. 420-430
    • Steinle, A.U.1    Weidenbach, H.2    Wagner, M.3
  • 47
    • 4444260453 scopus 로고    scopus 로고
    • PKC-C and -D regulate NFJB activation induced by cholecystokinin and TNF-> in pancreatic acinar cells
    • Satoh A, Gukovskaya AS, Nieto JM, et al. PKC-C and -D regulate NFJB activation induced by cholecystokinin and TNF-> in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004;287:582-591.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. 582-591
    • Satoh, A.1    Gukovskaya, A.S.2    Nieto, J.M.3
  • 48
    • 0037762993 scopus 로고    scopus 로고
    • Systemic NF-JB activation in a transgenic mouse model of acute pancreatitis
    • Gray KD, Simovic MO, Chapman WC, et al. Systemic NF-JB activation in a transgenic mouse model of acute pancreatitis. J Surg Res. 2003;110:310-314.
    • (2003) J Surg Res , vol.110 , pp. 310-314
    • Gray, K.D.1    Simovic, M.O.2    Chapman, W.C.3
  • 49
    • 0020713265 scopus 로고
    • Pulmonary complications in fatal haemorrhagic acute pancreatitis
    • Lankisch P, Hahlf G, Koop H. Pulmonary complications in fatal haemorrhagic acute pancreatitis. Dig Dis Sci. 1983;28:111-116.
    • (1983) Dig Dis Sci , vol.28 , pp. 111-116
    • Lankisch, P.1    Hahlf, G.2    Koop, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.