Cotinine effects on nicotine metabolism

Clinical Pharmacology and Therapeutics

Volumn 61, Issue 6, 1997, Pages 649-654

  Zevin, Shoshana ^b   Jacob III, Peyton ^b   Benowitz, Neal ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COTININE; NICOTINE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DISPOSITION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; COTININE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; NICOTINE; NICOTINIC AGONISTS; REFERENCE VALUES;

EID: 0031011328     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(97)90099-0     Document Type: Article

References (20)

1. Benowitz NL, Jacob P III, Jones RT, Rosenberg J. Interindividual variability in the metabolism and cardiovascular effects of nicotine in man. J Pharmacol Exp Ther 1982;221:368-72.
2. Benowitz NL, Jacob P III. Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers. Clin Pharmacol Ther 1993;53:316-23.
3. Lee BL, Benowitz NL, Jacob P III. Influence of tobacco abstinence on the disposition kinetics and effects of nicotine. Clin Pharmacol Ther 1987;41:474-9.
4. Jacob P III, Benowitz NL, Shulgin AT. Recent studies of nicotine metabolism in humans. Pharmacol Biochem Behav 1988;30:249-53.
5. Neurath GB, Dunger M, Orth D, Pein FG. Trans-3′-hydroxycotinine as a main metabolite in urine of smokers. Int Arch Occup Environ Health 1987;59: 199-201.
6. Kyerematen GA, Vesell ES. Metabolism of nicotine. Drug Metab Rev 1991;23:3-41.
7. Nakayama H, Nakashima T, Kurogochi Y. Participation of cytochrome P-450 in nicotine oxidation. Biochem Biophys Res Commun 1982;108:200-5.
8. McCracken NW, Cholerton S, Idle JR. Cotinine formation by cDNA-expressed human cytochrome P450. Med Sci Res 1992;20:877-8.
9. Cashman JR, Park SB, Yang ZC, Wrighton SA, Jacob P III, Benowitz NL. Metabolism of nicotine by human liver microsomes: stereoselective formation of transnicotine N′-oxide. Chem Res Toxicol 1992;5:639-46.
10. Nakajima M, Yamamoto T, Nunoya KI, Yokoi T, Nagashima K, Inoue K, et al. Characterization of CYP2A6 involved in 3′-hydroxylation of cotinine in human liver microsomes. J Pharmacol Exp Ther 1996; 277:1010-5.
11. Benowitz NL, Jacob P III. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clin Pharmacol Ther 1994;56:483-93.
12. Benowitz NL, Jacob P III, Denaro C, Jenkins R. Stable isotope studies of nicotine kinetics and bioavailability. Clin Pharmacol Ther 1991;49:270-7.
13. Jacob P III, Benowitz NL, Shulgin AT. Synthesis of optically pure deuterium-labelled nicotine, nornicotine and cotinine. J Labelled Comp Radiopharm 1988;25:1117-28.
14. Benowitz NL, Kuyt F, Jacob P III, Jones RT, Osman AL. Cotinine disposition and effects. Clin Pharmacol Ther 1983;34:604-11.
15. 2 in humans. Biol Mass Spectrom 1991;20:247-52.
16. Jacob P III, Shulgin AT, Yu L, Benowitz NL. Determination of the nicotine metabolite trans-3′-hydroxycotinine in urine of smokers using gas chromatography with nitrogen-selective detection or selected ion monitoring. J Chromatogr 1992;583:145-54.
17. Benowitz NL, Jacob P III, Fong I, Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 1994;268:296-303.
18. Curvall M, Elwin CE, Kazemi-Valla E, Warholm C, Enzell CR. The pharmacokinetics of cotinine in plasma and saliva from nonsmoking healthy volunteers. Eur J Clin Pharmacol 1990;38:281-7.
19. De Schepper PJ, Van Hecken A, Daenens P, Van Rossum JM. Kinetics of cotinine after oral and intravenous administration to man. Eur J Clin Pharmacol 1987;31:583-8.
20. Haley NJ, Sepkovic DW, Hoffmann D. Elimination of cotinine from body fluids: disposition in smokers and nonsmokers. Am J Public Health 1989;79: 1046-8.