Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome

Acta Neurologica Scandinavica

Volumn 117, Issue 3, 2008, Pages 186-190

  Lazaros, L ^a   Markoula, S ^a   Xita, N ^a   Giannopoulos, S ^a   Gogou, P ^a   Lagos, G ^a   Kyritsis, A P ^a   Georgiou, I ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Estrogen receptor alpha; Genetics, metabolic syndrome; Stroke

Indexed keywords

ESTROGEN RECEPTOR ALPHA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENOTYPE; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; ONSET AGE; STROKE;

AGE OF ONSET; AGED; BLOOD GLUCOSE; BRAIN; DYSLIPIDEMIAS; ELECTROCARDIOGRAPHY; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERTENSION; MAGNETIC RESONANCE IMAGING; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; STROKE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 38849107496     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2007.00926.x     Document Type: Article

References (20)

1. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999 340 : 1801 11.
2. Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME. Estrogen receptor mediates the protective effects of estrogen against vascular injury. Circ Res 2002 90 : 1087 92.
3. Herrington DM, Howard TD, Hawkins GA, et al. Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 2002 346 : 967 74.
4. Koivu TA, Fan YM, Mattila KM, et al. The effect of hormone replacement therapy on atherosclerotic severity in relation to ESR1 genotype in postmenopausal women. Maturitas 2003 44 : 29 38.
5. Lehtimaki T, Laaksonen R, Mattila KM, et al. Estrogen receptor gene variation is a determinant of coronary reactivity in healthy young men. Eur J Clin Invest 2002 32 : 400 4.
6. Lehtimaki T, Kunnas TA, Mattila KM, et al. Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study. J Mol Med 2002 80 : 176 80.
7. Almeida S, Hutz MH. Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population. Braz J Med Biol Res 2006 39 : 447 54.
8. Shearman AM, Cupples LA, Demissie S, et al. Association between estrogen receptor alpha gene variation and cardiovascular disease. J Am Med Assoc 2003 290 : 2263 70.
9. Ho KJ, Liao JK. Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular disease. Mol Interv 2002 2 : 219 28.
10. Schuit SC, Oei HH, Witteman JC, et al. Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. J Am Med Assoc 2004 291 : 2969 77
11. Shearman AM., Cooper JA, Kotwinski PJ, et al. Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circ Res 2006 98 : 590 2.
12. Koch W, Hoppmann P, Pfeufer A, Mueller JC, Schomig A, Kastrati A. No replication of association between estrogen receptor-a gene polymorphisms and susceptibility to myocardial infarction in a large sample of patients of European descent. Circulation 2005 112 : 2138 42.
13. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke 1993 24 : 35 41.
14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972 18 : 499 502.
15. Dubal DB, Zhu H, Yu J, et al. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 2001 98 : 1952 7.
16. Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 1999 19 : 6385 93.
17. Shearman AM, Cooper JA, Kotwinski PJ, et al. Estrogen receptor alpha gene variation and the risk for stroke. Stroke 2005 36 : 2281 2.
18. Pendaries C, Darblade B, Rochaix P, et al. The AF-1 activation-function of ERa may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proc Natl Acad Sci USA 2002 99 : 2205 10.
19. Pare G, Krust A, Karas R, et al. Estrogen receptor-a mediates the protective effects of estrogen against vascular injury. Circ Res 2002 90 : 1087 92.
20. Brouchet I, Krust A, Dupont S, Chambon P, Bayard F, Arnal J. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor α but not estrogen receptor β. Circulation 2001 103 : 423 8.