GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein

Journal of Virology

Volumn 84, Issue 6, 2010, Pages 2935-2945

  Kalt, Inna ^a   Borodianskiy Shteinberg, Tatyana ^a   Schachor, Adi ^a   Sarid, Ronit ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GENE PRODUCT; PROTEIN BCL 2; PROTEIN INTERACTING WITH CARBOXYL TERMINUS 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOPRECIPITATION; MITOCHONDRION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TWO HYBRID SYSTEM;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEOLUS; HERPESVIRUS 8, HUMAN; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; VIRAL PROTEINS;

HUMAN HERPESVIRUS 8;

EID: 77649147275     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00757-09     Document Type: Article

References (40)

1. Andersen, J. S., Y. W. Lam, A. K. Leung, S. E. Ong, C. E. Lyon, A. I. Lamond, and M. Mann. 2005. Nucleolar proteome dynamics. Nature 433:77-83.
2. Barboule, N., I. Truchet, and A. Valette. 2005. Localization of phosphorylated forms of Bcl-2 in mitosis: co-localization with Ki-67 and nucleolin in nuclear structures and on mitotic chromosomes. Cell Cycle 4:590-596.
3. Bellows, D. S., B. N. Chau, P. Lee, Y. Lazebnik, W. H. Burns, and J. M. Hardwick. 2000. Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins. J. Virol. 74:5024-5031.
4. Bellows, D. S., M. Howell, C. Pearson, S. A. Hazlewood, and J. M. Hardwick. 2002. Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins. J. Virol. 76:2469-2479.
5. Boisvert, F. M., S. van Koningsbruggen, J. Navascues, and A. I. Lamond. 2007. The multifunctional nucleolus. Nat. Rev. Mol. Cell Biol. 8:574-585.
6. Bruni, R., B. Fineschi, W. O. Ogle, and B. Roizman. 1999. A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and is recruited to the nucleus after infection. J. Virol. 73:3810-3817.
7. Chau, B. N., E. H. Cheng, D. A. Kerr, and J. M. Hardwick. 2000. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Mol. Cell 6:31-40.
8. Chen, Y. B., S. Y. Seo, D. G. Kirsch, T. T. Sheu, W. C. Cheng, and J. M. Hardwick. 2006. Alternate functions of viral regulators of cell death. Cell Death Differ. 13:1318-1324.
9. Cheng, E. H., J. Nicholas, D. S. Bellows, G. S. Hayward, H. G. Guo, M. S. Reitz, and J. M. Hardwick. 1997. A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proc. Natl. Acad. Sci. U. S. A. 94:690-694.
10. Cohen, A., D. G. Wolf, E. Guttman-Yassky, and R. Sarid. 2005. Kaposi's sarcoma-associated herpesvirus: clinical, diagnostic, and epidemiological aspects. Crit. Rev. Clin. Lab. Sci. 42:101-153.
11. Cuconati, A., and E. White. 2002. Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection. Genes Dev. 16:2465-2478.
12. Dourmishev, L. A., A. L. Dourmishev, D. Palmeri, R. A. Schwartz, and D. M. Lukac. 2003. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol. Mol. Biol. Rev. 67:175-212.
13. Flanagan, A. M., and A. Letai. 2008. BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2. Cell Death Differ. 15:580-588.
14. Granato, D. C., G. M. Machado-Santelli, and C. C. Oliveira. 2008. Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome. FEBS J. 275:4164-4178.
15. Gross, A., J. M. McDonnell, and S. J. Korsmeyer. 1999. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1899-1911.
16. Guo, J. Y., A. Yamada, T. Kajino, J. Q. Wu, W. Tang, C. D. Freel, J. Feng, B. N. Chau, M. Z. Wang, S. S. Margolis, H. Y. Yoo, X. F. Wang, W. G. Dunphy, P. M. Irusta, J. M. Hardwick, and S. Kornbluth. 2008. Aven-dependent activation of ATM following DNA damage. Curr. Biol. 18:933-942.
17. Hsu, Y. T., and R. J. Youle. 1997. Nonionic detergents induce dimerization among members of the Bcl-2 family. J. Biol. Chem. 272:13829-13834.
18. Huang, Q., A. M. Petros, H. W. Virgin, S. W. Fesik, and E. T. Olejniczak. 2002. Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc. Natl. Acad. Sci. U. S. A. 99:3428-3433.
19. Jamil, S., R. Sobouti, P. Hojabrpour, M. Raj, J. Kast, and V. Duronio. 2005. A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1. Biochem. J. 387:659-667.
20. Kim, Y. J., Y. E. Cho, Y. W. Kim, J. Y. Kim, S. Lee, and J. H. Park. 2008. Suppression of putative tumour suppressor gene GLTSCR2 expression in human glioblastomas. J. Pathol. 216:218-224.
21. Liang, C., P. Feng, B. Ku, I. Dotan, D. Canaani, B. H. Oh, and J. U. Jung. 2006. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 8:688-699.
22. Loh, J., Q. Huang, A. M. Petros, D. Nettesheim, L. F. van Dyk, L. Labrada, S. H. Speck, B. Levine, E. T. Olejniczak, and H. W. Virgin. 2005. A surface groove essential for viral Bcl-2 function during chronic infection in vivo. PLoS. Pathog. 1:e10.
23. Masa, S. R., R. Lando, and R. Sarid. 2008. Transcriptional regulation of the open reading frame 35 encoded by Kaposi's sarcoma-associated herpesvirus. Virology 371:14-31.
24. Morency, E., Y. Coute, J. Thomas, P. Texier, and P. Lomonte. 2005. The protein ICP0 of herpes simplex virus type 1 is targeted to nucleoli of infected cells. Arch. Virol. 150:2387-2395.
25. Ojala, P. M., K. Yamamoto, E. Castanos-Velez, P. Biberfeld, S. J. Korsmeyer, and T. P. Makela. 2000. The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nat. Cell Biol. 2:819-825.
26. Okahara, F., H. Ikawa, Y. Kanaho, and T. Maehama. 2004. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J. Biol. Chem. 279:45300-45303.
27. Okahara, F., K. Itoh, M. Ebihara, M. Kobayashi, H. Maruyama, Y. Kanaho, and T. Maehama. 2005. Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein. Anal. Biochem. 336:138-140.
28. Okahara, F., K. Itoh, A. Nakagawara, M. Murakami, Y. Kanaho, and T. Maehama. 2006. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol. Biol. Cell 17:4888-4895.
29. Pattingre, S., A. Tassa, X. Qu, R. Garuti, X. H. Liang, N. Mizushima, M. Packer, M. D. Schneider, and B. Levine. 2005. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122:927-939.
30. Paulose-Murphy, M., N. K. Ha, C. Xiang, Y. Chen, L. Gillim, R. Yarchoan, P. Meltzer, M. Bittner, J. Trent, and S. Zeichner. 2001. Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). J. Virol. 75:4843-4853.
31. Sarid, R., T. Sato, R. A. Bohenzky, J. J. Russo, and Y. Chang. 1997. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nat. Med. 3:293-298.
32. Scherl, A., Y. Coute, C. Deon, A. Calle, K. Kindbeiter, J. C. Sanchez, A. Greco, D. Hochstrasser, and J. J. Diaz. 2002. Functional proteomic analysis of human nucleolus. Mol. Biol. Cell 13:4100-4109.
33. Schmidt-Kastner, R., C. Aguirre-Chen, T. Kietzmann, I. Saul, R. Busto, and M. D. Ginsberg. 2004. Nuclear localization of the hypoxia-regulated proapoptotic protein BNIP3 after global brain ischemia in the rat hippocampus. Brain Res. 1001:133-142.
34. Schmitt, E., M. Beauchemin, and R. Bertrand. 2007. Nuclear colocalization and interaction between bcl-xL and cdk1(cdc2) during G2/M cell-cycle checkpoint. Oncogene 26:5851-5865.
35. Smith, J. S., I. Tachibana, U. Pohl, H. K. Lee, U. Thanarajasingam, B. P. Portier, K. Ueki, S. Ramaswamy, S. J. Billings, H. W. Mohrenweiser, D. N. Louis, and R. B. Jenkins. 2000. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. Genomics 64:44-50.
36. Sulis, M. L., and R. Parsons. 2003. PTEN: from pathology to biology. Trends Cell Biol. 13:478-483.
37. Walensky, L. D. 2006. BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ. 13:1339-1350.
38. Wei, Y., S. Pattingre, S. Sinha, M. Bassik, and B. Levine. 2008. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30:678-688.
39. Widmer, I., M. Wernli, F. Bachmann, F. Gudat, G. Cathomas, and P. Erb. 2002. Differential expression of viral Bcl-2 encoded by Kaposi's sarcomaassociated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions. J. Virol. 76:2551-2556.
40. Yim, J. H., Y. J. Kim, J. H. Ko, Y. E. Cho, S. M. Kim, J. Y. Kim, S. Lee, and J. H. Park. 2007. The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Cell Death Differ. 14:1872-1879.