No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer

Molecular Carcinogenesis

Volumn 48, Issue 7, 2009, Pages 581-585

  Pallier, Karine ^a,b   Houllier, Anne Marie ^a,b   Le Corre, Delphine ^a,b   Cazes, Aurélie ^c   Laurent Puig, Pierre ^a,b,c   Blons, Hélène ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

Amplification; Cancer; Lung; Mutation; PXN

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; K RAS PROTEIN; PAXILLIN; PROTEIN KINASE LKB1; PROTEIN P53; SCATTER FACTOR RECEPTOR; PRIMER DNA;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; INCIDENCE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SOMATIC MUTATION; GENETICS; INTRON; LUNG TUMOR; NERVE FIBER; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

AXONS; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; DNA PRIMERS; HUMANS; INTRONS; LUNG NEOPLASMS; PAXILLIN; POLYMERASE CHAIN REACTION;

EID: 67649225195     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20538     Document Type: Article

References (13)

1. Turner CE. Paxillin and focal adhesion signalling. Nat Cell Biol 2000;2:E231-E236.
2. Schaller MD. Paxillin: A focal adhesion-associated adaptor protein. Oncogene 2001;20:6459-6472. (Pubitemid 32977851)
3. Jagadeeswaran R, Surawska H, Krishnaswamy S, et al. Paxillin is a target for somatic mutations in lung cancer: Implications for cell growth and invasion. Cancer Res 2008; 68:132-142.
4. Blons H, Pallier K, Le Corre D, et al. Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. BMC Med Genomics 2008;1:25.
5. Liu H, Wang H, Shi Z, et al. TaqMan probe array for quantitative detection of DNA targets. Nucleic Acids Res 2006;34:e4. (Pubitemid 43160067)
6. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408. (Pubitemid 34164012)
7. Weir BA, Woo MS, Getz G, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007;450:893-898. (Pubitemid 350231325)
8. Akbari M, Hansen MD, Halgunset J, Skorpen F, Krokan HE. Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner. J Mol Diagn 2005;7:36-39. (Pubitemid 40310163)
9. Williams C, Ponten F, Moberg C, et al. A high frequency of sequence alterations is due to formalin fixation of archival specimens. Am J Pathol 1999;155:1467-1471.
10. Hashimoto K, Ohsawa K, Kimura M. Mutations induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lacZ and cII genes of Muta Mouse. Mutat Res 2004;560: 119-131. (Pubitemid 38638789)
11. Cappuzzo F, Janne PA, Skokan M, et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 2009;20: 298-304.
12. Daskalos A, Nikolaidis G, Xinarianos G, et al. Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int J Cancer 2008; 124:81-87.
13. Wallace NA, Belancio VP, Deininger PL. L1 mobile element expression causes multiple types of toxicity. Gene 2008;419: 75-81.