Foxn1 gene knockout suppresses sexual attractiveness and pheromonal components of male urine in inbred mice

Chemical Senses

Volumn 35, Issue 1, 2010, Pages 47-56

  Zhang, Jian Xu ^a   Sun, Lixing ^b   Zhang, Yao Hua ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b CENTRAL WASHINGTON UNIVERSITY   (United States)

Author keywords

Foxn1; Handicap hypothesis; Mate choice; Pheromone

Indexed keywords

PROTEIN FOXN1; SEX PHEROMONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; WHN PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BAGG ALBINO MOUSE; CD 1 MOUSE; CONTROLLED STUDY; FEMALE; GENETIC CORRELATION; IMMUNE DEFICIENCY; KNOCKOUT GENE; MALE; MATE CHOICE; MOUSE; MOUSE STRAIN; NONHUMAN; OLFACTORY DISCRIMINATION; PREPUTIAL GLAND; PRIORITY JOURNAL; SEXUAL BEHAVIOR; STRAIN DIFFERENCE; URINALYSIS; URINE ODOR; ANIMAL; GENETICS; INBREEDING; MOUSE MUTANT; URINE;

ANIMALIA; MUS;

ANIMALS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; INBREEDING; MALE; MATING PREFERENCE, ANIMAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; SEX ATTRACTANTS;

EID: 77449130797     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjp081     Document Type: Article

References (62)

1. Alonso-Alvarez C, Bertrand S, Sorci G. 2007. Energetic reserves, leptin and testosterone: a refinement of the immunocompetence handicap hypothesis. Biol Lett. 3:271-274.
2. Andersson M. 1994. Sexual selection. Princeton (NJ): Princeton University Press.
3. Barnard CJ, Behnke JM, Gage AR, Brown H, Smithurst PR. 1997a. Modulation of behaviour and testosterone concentration in immunodepressed male laboratory mice (Mus musculus). Physiol Behav. 61: 907-917.
4. Barnard CJ, Behnke JM, Gage AR, Brown H, Smithurst PR. 1997b. Immunity costs and behavioural modulation in male laboratory mice (Mus musculus) exposed to the odour of females. Physiol Behav. 62:857-866.
5. Barnard CJ, Behnke JM, Gage AR, Brown H, Smithurst PR. 1998. The role of parasite-induced immunodepression, rank and social environment in the modulation of behaviour and hormone concentration in male laboratory mice (Mus musculus). Proc R Soc B. 265:693-701.
6. Champagne FA, Curley JP, Keverne EB, Bateson PPG. 2007. Natural variations in postpartum maternal care in inbred and outbred mice. Physiol Behav. 91:325-334.
7. Clayton DH. 1991. The influence of parasites on host sexual selection. Parasitol Today. 7:329-334.
8. Crabbe JC, Wahlsten D, Dudek BC. 1999. Genetics of mouse behavior: interactions with laboratory environment. Science. 284:1670-1672.
9. Duffy DL, Ball GF. 2002. Song predicts immunocompetence in male European starlings (Sturnus vulgaris). Proc R Soc B. 269:847-852.
10. Falstad I, Karter AJ. 1992. Parasites, bright males, and the immunocompetence handicap. Am Nat. 139:603-622.
11. Hamilton WD, Poulin R. 1997. The Hamilton and Zuk hypothesis revisited: a meta-analytical approach. Behaviour. 134:299-320.
12. Hamilton WD, Zuk M. 1982. Heritable true fitness and bright birds: a role for parasites? Science. 218:384-387.
13. Harvey S, Jemiolo B, Novotny M. 1989. Pattern of volatile compounds in dominant and subordinate male mouse urine. J ChemEcol. 15:2061-2071.
14. Hillgarth N, Ramenofsky M, Wingfield J. 1997. Testosterone and sexual selection. Behav Ecol. 8:108-109.
15. Hurst JL, Rich TJ. 1999. Scent marks as competitive signals of mate quality. In: Johnston RE, Muller-Schwarze D & Sorensen P, editors. Advances in chemical signals in vertebrates. New York: Plenum Press. p. 209-225.
16. Ilmonen P, Stundner G, Thoss M, Penn DJ. 2009. Females prefer the scent of outbred males: good-genes-as-heterozygosity? BMC Evol Biol. 9: 104-113.
17. Isaacson JH, Cattanach BM. 1962. Report. Mouse News Lett. 27:31.
18. Isles AR, Baum MJ, Ma D, Keverne EB, Allen ND. 2001. Genetic imprinting: urinary odour preferences in mice. Nature. 409:783-784.
19. Jemiolo B, Alberts J, Sochinski-Wiggins S, Harvey S. 1985. Behavioral and endocrine responses of female mice to synthetic analogues of volatile compounds in male urine. Anim Behav. 33:1114-1118.
20. Jemiolo B, Xie T-M, Novotny M. 1991. Socio-sexual olfactory preference in female mice: attractiveness of synthetic chemosignals. Physiol Behav. 50:1119-1122.
21. Jones RB, Nowell NW. 1973. A comparison of the aversive and female attractant properties of urine from dominant and subordinate male mice. Anim Learn Behav. 2:141-144.
22. Jordan WC, Bruford MW. 1998. New perspectives on mate choice and the MHC. Heredity. 81:127-133.
23. Kavaliers M, Choleris E, Pfaff DW. 2005. Genes, odours and the recognition of parasitized individuals by rodents. Trends Parasit. 21:423-429.
24. Kavaliers M, Colwell DD. 1995. Discrimination by female mice between the odours of parasitized and non-parasitized males. Proc R Soc B. 261:31-35.
25. Keller LF, Waller DM. 2002. Inbreeding effects in wild populations. Trends Ecol Evol. 17:230-241.
26. Kelly MA, Rubinstein M, Phillips TJ, Lessov CN, Burkhart-Kasch S, Zhang G, Bunzow JR, Fang Y, Gerhardt GA, Grandy DK, et al. 1998. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci. 18:3470-3479.
27. Köpf-Maier P, Mboneko VF. 1990. Anomalies in the hormonal status of athymic nude mice. J Cancer Res Clin Oncol. 116:229-231.
28. Kurtz J, Sauer KP. 1999. The immunocompetence handicap hypothesis testing the genetic predictions. Proc R Soc B. 266:2515-2522.
29. Liu Y-J, Zhang J-X, Cao X-P, Zhang JH, Bao W-D. 2008. Social dominance, sexual attractiveness and pheromonal communication in male mice. Acta Zool Sin. 54:399-406.
30. Liu Y-J, Zhang J-X, Zhang J-H, Bao W-D, Liu D-Z. Forthcoming. 2009. Vomeronasal organ ablation elicits chemosensory dysfunction and abnormal behavior in mice. J Ethol. doi: 101007/s10164-009-0180-x.
31. Logue SF, Owen EH, Rasmussen DL, Wehner JM. 1997. Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience. 80:1075-1086.
32. Mecklenburg L, Nakamura M, Sundberg JP, Paus R. 2001. The nu mouse skin phenotype: the role of foxn1 in hair follicle development and cycling. Exp Mol Pathol. 71:171-178.
33. Nevison CM, Hurst JL, Barnard CJ. 1999. Strain-specific effects of cage enrichment in male laboratory mice (Mus Musculus). Anim Welfare. 8:361-379.
34. Novotny M, Harvey S, Jemiolo B. 1990. Chemistry of male dominance in the house mouse (Mus domesticus). Experientia. 46:109-113.
35. Novotny M, Jemiolo B, Wiesler D, Ma W, Harvey S, Xu F, Xie T-M, Carmack M. 1999. A unique urinary constituent, 6-hydroxy-6-methyl-3heptanone, is a pheromone that accelerates puberty in female mice. Chem Biol. 6:377-383.
36. Pankevich DE, Baum MJ, Cherry JA. 2004. Olfactory sex discrimination persists, whereas the preference for urinary odorants from estrous females disappears in male mice after vomeronasal organ removal. J Neurosci. 24:9451-9457.
37. Penn DJ, Potts WK. 1998a. Chemical signals and parasite-mediated sexual selection. Trends Ecol Evol. 13:391-396.
38. Penn DJ, Potts WK. 1998b. MHC-disassortative mating preferences reversed by cross-fostering. Proc R Soc B. 265:1299-1306.
39. Penn D, Schneider G, White K, Slev P, Potts W. 1998. Influenza infection neutralizes the attractiveness of male odor to female mice (Mus musculus). Ethology. 104:685-694.
40. Pusey AP, Wolf M. 1996. Inbreeding avoidance in animals. Trends Ecol Evol. 11:201-206.
41. Rantala MJ, Kortet R, Kotiaho JS, Vainikka A, Suhonen J. 2003. Condition dependence of pheromones and immune function in the grain beetle, Tenebrio molitor. Funct Ecol. 17:534-540.
42. Rantala MJ, Vainikala A, Koret R. 2003. The role of juvenile hormone in immunue function and pheromone production trade-offs: a test of the immunocompetence handicap principle. Proc R Soc B. 270:2257-2261.
43. Reid JM, Arcese P, Cassidy ALEV, Marr AB, Smith JNM, Keller LF. 2005. Hamilton and Zuk meet heterozygosity? Song repertoire size indicates inbreeding and immunity in song sparrows (Melospoza melodia). Proc R Soc B. 272:481-487.
44. Riviére S, Challet L, Fluegge D, Spehr M, Rodriguez I. 2009. Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature. 459:574-577.
45. Roberts ML, Buchanan KL, Evans MR. 2004. Testing the immunocompetence handicap hypothesis: a review of the evidence. Anim Behav. 68:227-239.
46. Roberts SC, Gosling LM. 2003. Genetic similarity and quality interact in mate choice decisions by female mice. Nat Genet. 35:103-106.
47. Schlake T. 2001. The nude gene and the skin. Exp Dermatol. 10:293-304.
48. Schorpp M, Hofmann M, Dear TN, Boehm T. 1997. Characterization of mouse and human nu genes. Immunogenetics. 46:509-515.
49. Simmons LW, Zuk M, Rotenberry JT. 2005. Immune function reflected in calling song characteristics in a natural population of the cricket Teleogryllus commodus. Anim Behav. 69:1235-1241.
50. Singer AG, Beauchamp GK, Yamazaki K. 1997. Volatile signals of the major histocompatibility complex in male mouse urine. Proc Natl Acad Sci USA. 94:2210-2214.
51. Spearow JL, Doemeny P, Sera R, Leffler R, Barkley M. 1999. Genetic variation in susceptibility to endocrine disruption by estrogen in mice. Science. 285:1259-1261.
52. Sun L, Müller-Schwarze D. 1998a. Anal gland secretion codes for family membership in the beavers. Behav Ecol Sociobiol. 44:199-208.
53. Sun L, Müller-Schwarze D. 1998b. Anal gland secretion codes for relatedness in the beaver, Castor canadensis. Ethology. 104:917-927.
54. Vainikka A, Rantala MJ, Seppälä O. 2007. Do male mealworm beetles, Tenebrio molitor, sustain the honesty of pheromone signals under immune challenge? Acta Ethol. 10:63-72.
55. Verhulst S, Dieleman SJ, Parmentier HK. 1999. A tradeoff between immunocompetence and sexual ornamentation in domestic fowl. Proc Natl Acad Sci USA. 96:4478-4481.
56. Võikar V, Kõks S, Vasar E, Rauvala H. 2001. Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies. Physiol Behav. 72:271-281.
57. Yamazaki K, Beauchamp GK, Shen FW, Bard J, Boyse EA. 1994. Discrimination of odortypes determined by the major histocompatibility complex among outbred mice. Proc Natl Acad Sci USA. 91:3735-3738.
58. Zahavi A. 1975. Mate selection-a selection for a handicap. J Theor Biol. 53:205-214.
59. Zala SM, Potts WK, Penn DJ. 2004. Scent-marking displays provide honest signals of health and infection. Behav Ecol. 15:338-344.
60. Zhang J-X, Liu Y-J, Zhang J-H, Sun L. 2008. Dual role of preputial gland secretion and its major components in sex recognition of mice. Physiol Behav. 95:388-394.
61. Zhang J-X, Rao X-P, Sun L, Zhao C-H, Qin X-W. 2007. Putative chemical signals about sex, individual and genetic background in the preputial gland and urine of the house mouse (Mus musculus). Chem Senses. 32:293-303.
62. Zhang J-X, Sun L-X, Novotny M. 2007. Mice respond differently to urine and its major volatile constituents from male and female ferrets. J Chem Ecol. 33:603-612.