Olfactory sex discrimination persists, whereas the preference for urinary odorants from estrous females disappears in male mice after vomeronasal organ removal

Journal of Neuroscience

Volumn 24, Issue 42, 2004, Pages 9451-9457

  Pankevich, Diana E ^a   Baum, Michael J ^a   Cherry, James A ^b  

^a Boston University   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Accessory olfactory bulb; Habituation; Odor detection; Pheromone; Sexual behavior; Urinary

Indexed keywords

PHEROMONE; VOLATILE AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; HABITUATION; MALE; MOUSE; NONHUMAN; ODOR; OLFACTORY DISCRIMINATION; OLFACTORY SYSTEM; OVARIECTOMY; PRIORITY JOURNAL; SEX DETERMINATION; SEXUAL BEHAVIOR; SMELLING; VOMERONASAL ORGAN;

ANIMALS; DISCRIMINATION (PSYCHOLOGY); ESTRUS; FEMALE; MALE; MICE; MICE, INBRED C57BL; ORCHIECTOMY; OVARIECTOMY; SEXUAL BEHAVIOR, ANIMAL; SMELL; URINE; VOMERONASAL ORGAN;

EID: 7044231115     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2376-04.2004     Document Type: Conference Paper

References (29)

1. Baum MJ, Keverne EB (2002) Sex difference in attraction thresholds for volatile odors from male and estrous female mouse urine. Horm Behav 41:213-219.
2. Baum MJ, Brown JJ, Kica E, Rubin BS, Johnson RS, Papaioannou VE (1994) Effect of a null mutation of the c-fos proto-oncogene on sexual behavior of male mice. Biol Reprod 50:1040-1048.
3. Beauchamp GK, Martin IG, Wysocki CJ, Wellington JL (1982) Chemoinvestigatory and sexual behavior of male guinea pigs following vomeronasal organ removal. Physiol Behav 29:329-336.
4. Beckman M (2002) When in doubt, mice mate rather than hate. Science 295:782.
5. Clancy AN, Coquelin A, Macrides F, Gorski RA, Noble EP (1984) Sexual behavior and aggression in male mice: involvement of the vomeronasal system. J Neurosci 4:2222-2229.
6. Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, Ogawa S, Zufall F, Mombaerts P (2002) Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419:70-74.
7. Diamond M (1970) Intromission pattern and species vaginal code in relation to induction of pseudopregnancy. Science 169:995-997.
8. Halem HA, Baum MJ, Cherry JA (2001) Sex difference and steroid modulation of pheromone-induced immediate early genes in the two zones of the mouse accessory olfactory system. J Neurosci 21:2474-2480.
9. Halpern M, Martinez-Marcos A (2003) Structure and function of the vomeronasal system: an update. Prog Neurobiol 70:245-318.
10. Keverne EB (2002) Pheromones, vomeronasal function, and gender-specific behavior. Cell 108:735-738.
11. Key B, Giorgi PP (1986) Soybean agglutinin binding to the olfactory systems of the rat and mouse. Neurosci Lett 69:131-136.
12. Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R (2002) Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci USA 99:6376-6381.
13. Luo M, Fee MS, Katz LC (2003) Encoding pheromonal signals in the accessory olfactory bulb of behaving mice. Science 299:1196-1201.
14. Ma D, Allen ND, Van Bergen YC, Jones CM, Baum MJ, Keverne EB, Brennan PA (2002) Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice. Eur J Neurosci 16:2317-2323.
15. McCarthy MM, Auger AP (2002) He's a lover, not a fighter - smell, sex and civility. Trends Endocrinol Metab 13:183-184.
16. Meredith M (1986) Vomeronasal organ removal before sexual experience impairs male hamster mating behavior. Physiol Behav 36:737-743.
17. Norlin EM, Gussing F, Berghard A (2003) Vomeronasal phenotype and behavioral alterations in G alpha i2 mutant mice. Curr Biol 13:1214-1219.
18. O'Connell RJ, Meredith M (1984) Effects of volatile and nonvolatile chemical signals on male sex behaviors mediated by the main and accessory olfactory systems. Behav Neurosci 98:1083-1093.
19. Pankevich D, Baum MJ, Cherry JA (2003) Removal of the superior cervical ganglia fails to block Fos induction in the accessory olfactory system of male mice after exposure to female odors. Neurosci Lett 345:13-16.
20. Petrulis A, Peng M, Johnston RE (1999) Effects of vomeronasal organ removal on individual odor discrimination, sex-odor preference, and scent marking by female hamsters. Physiol Behav 66:73-83.
21. Powers JB, Fields RB, Winans SS (1979) Olfactory and vomeronasal system participation in male hamsters' attraction to female vaginal secretions. Physiol Behav 22:77-84.
22. Schaefer ML, Young DA, Restrepo D (2001) Olfactory fingerprints for major histocompatibility complex-determined body odors. J Neurosci 21:2481-2487.
23. Schaefer ML, Yamazaki K, Osada K, Restrepo D, Beauchamp GK (2002) Olfactory fingerprints for major histocompatibility complex-determined body odors II: relationship among odor maps, genetics, odor composition, and behavior. J Neurosci 22:9513-9521.
24. Stowers L, Holy TE, Meister M, Dulac C, Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295:1493-1500.
25. Trinh K, Storm DR (2003) Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium. Nat Neurosci 6:519-525.
26. Wysocki CJ, Lepri JJ (1991) Consequences of removing the vomeronasal organ. J Steroid Biochem Mol Biol 39:661-669.
27. Wysocki CJ, Wysocki LM (1995) Surgical removal of the mammalian vomeronasal organ and its verification. In: Experimental cell biology of taste and olfaction (Speilman AI, Brand JG, eds), pp 49-57. New York: CRC.
28. Wysocki CJ, Nyby J, Whitney G, Beauchamp GK, Katz Y (1982) The vomeronasal organ: primary role in mouse chemosensory gender recognition. Physiol Behav 29:315-327.
29. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404:99-103.