Intensity of transplant chronic rejection correlates with level of graft-infiltrating regulatory cells

Journal of Heart and Lung Transplantation

Volumn 29, Issue 3, 2010, Pages 335-341

  Semiletova, Natalya V ^a   Shen, Xiu Da ^a   Baibakov, Boris ^b   Andakyan, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

chronic rejection; MHC; peptide; T regulatory cells; tolerance

Indexed keywords

CYCLOSPORIN; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; DOWN REGULATION; GRAFT NECROSIS; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MODELS, ANIMAL; RATS; RATS, INBRED ACI; RATS, INBRED BUF; RATS, INBRED LEW; RATS, INBRED WF; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 77349121587     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2009.08.003     Document Type: Article

References (19)

1. Stephens L.A., Barclay A.N., and Mason D. Phenotypic characterization of regulatory CD4+CD25+ T cells in rats. Int Immunol 16 (2004) 365-375
2. Joffre O., Santolaria T., Calise D., et al. Prevention of acute and chronic allograft rejection with CD4+CD25+FoxP3+ regulatory T lymphocytes. Nat Med 14 (2008) 88-92
3. Bharat A., Fields R.C., and Mohanakumar T. Regulatory T cell-mediated transplantation tolerance. Immunol Res 33 (2005) 195-212
4. Joetham A., Matsubara S., Okamoto M., et al. Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses. J Immunol 180 (2008) 7117-7124
5. Koshiba T., Kitade H., Van Damme B., et al. Regulatory cell-mediated tolerance does not protect against chronic rejection. Transplantation 76 (2003) 588-596
6. Waaga-Gasser A.M., Grimm M.R., Lutz J., et al. Regulatory allospecific T cell clones abrogate chronic allograft rejection. J Am Soc Nephrol 20 (2009) 820-830
7. Bunnag S., Allanach K., Jhangri G.S., et al. FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. Am J Transplant 8 (2008) 1423-1433
8. Dijke I.E., Caliskan K., Korevaar S.S., et al. FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients. Transplant Immunol 18 (2008) 250-254
9. Caballero A., Fernandez N., Lavado R., et al. Tolerogenic response: allorecognition pathways. Transplant Immunol 17 (2006) 3-6
10. Wang D., Opelz G., and Terness P. A simplified technique for heart transplantation in rats: abdominal vessel branch-sparing and modified venotomy. Microsurgery 26 (2006) 470-472
11. Semiletova N.V., Shen X.D., Feldman D.M., et al. Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains. Cell Immunol 248 (2007) 48-58
12. Mellanby R.J., Phillips J.M., Parish N.M., et al. Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice. Autoimmunity 41 (2008) 383-394
13. Lynch R.J., and Platt J.L. Accommodation in organ transplantation. Curr Opin Organ Transplant 13 (2008) 165-170
14. Koshiba T., Giulietti A., Van Damme B., et al. Paradoxical early upregulation of intragraft Th1 cytokines is associated with graft acceptance following donor-specific blood transfusion. Transplant Int 16 (2003) 179-185
15. Yamaura K., Ito K., Tsukioka K., et al. Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy. Circulation 110 (2004) 1650-1657
16. Koksoy S., Elpek K.G., Yolcu E.S., et al. Tolerance to rat hearts grafts induced by intrathymic immunomodulation is mediated by indirect recognition primed CD4CD25 T-reg cells. Transplantation 79 (2005) 1492-1497
17. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 (1993) 801-809
18. Souza A.I., Felkin L.E., McCormack A.M., et al. Sequential expression of three known protective genes in cardiac biopsies after transplantation. Transplantation 79 (2005) 584-590
19. Park W.D., Grande J.P., Ninova D., et al. Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury. Am J Transplant 3 (2003) 952-958