Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 1875-1881

  Karuppasamy, Muthukumar ^a   Mahapatra, Manojkumar ^a   Yabanoglu, Samiye ^b   Ucar, Gulberk ^b   Sinha, Barij Nayan ^a   Basu, Arijit ^a   Mishra, Nibha ^a   Sharon, Ashoke ^a   Kulandaivelu, Umasankar ^c   Jayaprakash, Venkatesan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY   (India)

^b HACETTEPE UNIVERSITY   (Turkey)

^c Vaagdevi College of Pharmacy   (India)

Author keywords

MAO inhibitors; Molecular docking; Pyrazolines

Indexed keywords

3,5 DIARYL 4,5 DIHYDRO 1H PYRAZOLE; 3,5 DIARYL PYRAZOLINE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; MONOAMINE OXIDASE A INHIBITOR; N,3,5 TRIARYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR DOCKING; NONHUMAN; RAT;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; KINETICS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77349110399     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.043     Document Type: Article

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