Highly effective and slow-biodegradable network-type cationic gene delivery polymer: Small library-like approach synthesis and characterization

Biomaterials

Volumn 27, Issue 10, 2006, Pages 2292-2301

  Kim, Hyun Jin ^a   Kwon, Min Sung ^a   Choi, Joon Sig ^b   Yang, Seung Min ^a   Yoon, Jae Keun ^a   Kim, Kwan ^a   Park, Jong Sang ^a  

^a Seoul National University   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Biodegradation; Gene therapy; Gene transfer; Nanoparticle; Self assembley; Surface modification

Indexed keywords

BIODEGRADATION; DNA; ESTERS; NANOSTRUCTURED MATERIALS; PHYSIOLOGY; POSITIVE IONS; SELF ASSEMBLY; SURFACE TREATMENT; SYNTHESIS (CHEMICAL);

GENE THERAPY; NANOPARTICLE; NETWORK-TYPE STRUCTURE; POLYMER SYNTHESIS;

GENE TRANSFER;

AMINOCAPROIC ACID; BIOPOLYMER; BUFFER; DNA; DRUG CARRIER; POLY(AMINO ESTER); POLYAMINOAMINE; POLYETHYLENEIMINE; TERTIARY AMINE; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA TRANSFECTION; DRUG DEGRADATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBEDDING; EMBRYO; GENE LIBRARY; GENETIC LINKAGE; HUMAN; HUMAN CELL; MELTING POINT; NONVIRAL GENE DELIVERY SYSTEM; POLYMERIZATION; PRIORITY JOURNAL; SERUM; SURFACE PROPERTY;

BIOCOMPATIBLE MATERIALS; CATIONS; CELL LINE; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; HUMANS; MICROSCOPY, ATOMIC FORCE; MOLECULAR STRUCTURE; PARTICLE SIZE; POLYMERS; TRANSFECTION;

EID: 28844434193     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2005.10.023     Document Type: Article

References (24)

1. M.A. Kay, D. Liu, and P.M. Hoogerbrugge Gene therapy Proc Natl Acad Sci USA 94 1997 12,744 12,746
2. M. Nishikawa, and L. Huang Nonviral vectors in the new millennium: delivery barriers in gene transfer Hum Gene Ther 12 2001 861 870
3. E. Check Gene therapy: a tragic setback Nature 420 2002 116 118
4. D. Putnam, and R. Langer Poly(4-hydroxy-l-proline ester): low-temperature polycondensation and plasmid DNA complexation Macromolecules 32 1999 3658 3662
5. Y. Lim, C. Kim, K. Kim, S.W. Kim, and J. Park Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-l- glycolic acid] J Am Chem Soc 122 2000 6524 6525
6. D.M. Lynn, and R. Langer Degradable poly(β-animo esters): synthesis, characterization, and self-assembly with plasmid DNA J Am Chem Soc 122 2000 10761 10786
7. J. Wang, H. Mao, and K.W. Leong A novel biodegradable gene carrier based on polyphoester J Am Chem Soc 123 2001 9480 9481
8. Y. Lim, S. Kim, Y. Lee, W. Lee, T. Yang, and M. Lee Cationic hyperbranched poly(amino ester): a novel class of DNA condensing molecule with cationic surface, biodegradable three-dimensional structure, and tertiary amine groups in the interior J Am Chem Soc 123 2001 2460 2461
9. A. Akinc, D.M. Lynn, D.G. Anderson, and R. Langer Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery J Am Chem Soc 125 2003 5316 5323
10. Y. Lim, Y.H. Choi, and J. Park A self-destroying polycationic polymer: biodegradable poly(4-hydroxy-l-proline ester) J Am Chem Soc 121 1999 5633 5639
11. Y. Lim, S. Kim, H. Suh, and J. Park Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier Bioconjugate Chem 13 2002 952 957
12. C. Gao, and D. Yan Hyperbranched polymers: from synthesis to applications Prog Polym Sci 29 2004 183 275
13. M. Jikei, S.H. Chon, M. Kakimoto, S. Kawauchi, T. Imase, and J. Watanabe Synthesis of hyperbranched aromatic polyamide from aromatic diamines and trimesic acid Macromolecules 32 1999 2061 2064
14. S. Tanaka, K. Takeuchi, M. Asai, T. Iso, and M. Ueda Preparation of hyperbranched copolymers constituted of triphenylamine and phenylene units Synth Metals 119 2001 139 140
15. H. Chen, and J. Yin Synthesis and characterization of hyperbranched polyimides with good organosolubility and thermal properties based on a new triamine and conventional dianhydrides J Polym Sci A: Polym Chem 40 2002 3804 3814
16. 3) Polym Bull 49 2003 313 320
17. 3 monomers Polym J 35 2003 280 285
18. M.J. Lee, S.S. Cho, J.R. You, Y. Lee, B.D. Kang, and J.S. Choi Intraperitoneal gene delivery mediated by a novel cationic liposome in a peritoneal disseminated ovarian cancer model Gene Ther 9 2002 859 866
19. J.S. Choi, K. Nam, J. Kim, J. Lee, and J. Park Enhanced transfection efficiency of PAMAM dendrimer by surface modification with l-arginine J Control Release 99 2004 445 456
20. J.C. Perales, T. Ferkol, M. Molas, and R.W. Hanson An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes Eur J Biochem 226 1994 255 266
21. N. Malik, R. Wiwattanapatapee, R. Klopsch, K. Lorenz, H.J. Frey, and W. Weener Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labeled polyamidoamine dendrimers in vivo J Control Release 65 2000 133 148
22. R. Jevprasesphant, J. Penny, R. Jalal, A. Attwood, N.B. Mckeown, and A. D'Emanuele The influence of surface modification on the cytotoxicity of PAMAM dendrimers Int J Pharm 252 2003 263 266
23. L. Dekie, V. Toncheva, P. Dubruel, H. Schacht, L. Barrett, and L.W. Seymour Poly l-glutamic acid derivatives as vectors for gene therapy J Control Release 65 2000 187 202
24. O. Boussif, T. Delair, C. Brua, L. Veron, A. Pavirani, and H.V. Kolbe Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro Bioconjugate Chem 10 1999 877 883