The effect of different patterns of growth hormone administration on the IGF axis and somatic and skeletal growth of the dwarf rat

American Journal of Physiology - Endocrinology and Metabolism

Volumn 298, Issue 3, 2010, Pages

  Westwood, Melissa ^a   Maqsood, Arfa R ^a   Solomon, Mattea ^a   Whatmore, Andrew J ^a   Davis, Julian R E ^a   Baxter, Robert C ^b   Gevers, Evelien F ^c   Robinson, Iain C A F ^a   Clayton, Peter E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Acid labile subunit; Growth hormone deficiency; Infradian; Insulin like growth factor; Insulin like growth factor binding protein

Indexed keywords

GROWTH HORMONE; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; OXYTETRACYCLINE; RECOMBINANT GROWTH HORMONE; SODIUM CHLORIDE; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY GROWTH; BODY HEIGHT; BODY WEIGHT; BONE GROWTH; BONE MASS; CHEMICAL LABELING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMUR; GROWTH HORMONE DEFICIENCY; KIDNEY; KIDNEY MASS; LIVER WEIGHT; MALE; MEASUREMENT; MUSCLE; MUSCLE MASS; NONHUMAN; ORGAN GROWTH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TIBIA; ULTRADIAN RHYTHM;

ANIMALS; BODY SIZE; BONE DEVELOPMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DWARFISM, PITUITARY; GROWTH HORMONE; MALE; RATS; SOMATOMEDINS;

EID: 77349098988     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00234.2009     Document Type: Article

References (59)

1. Aguiar-Oliveira MH, Gill MS, de A Barretto ES, Alcântara MR, Miraki-Moud F, Menezes CA, Souza AH, Martinelli CE, Pereira FA, Salvatori R, Levine MA, Shalet SM, Camacho-Hubner C, Clayton PE. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J Clin Endocrinol Metab 84: 4118-4126, 1999.
2. Alba M, Fintini D, Salvatori R. Effects of recombinant mouse growth hormone treatment on growth and body composition in GHRH knock out mice. Growth Horm IGF Res 15: 275-282, 2005.
3. Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75: 73-82, 1993.
4. Batchelor DC, Lewis RM, Breier BH, Gluckman PD, Skinner SJ. Fetal rat lung epithelium has a functional growth hormone receptor coupled to tyrosine kinase activity and insulin-like growth factor binding protein-2 production. J Mol Endocrinol 21: 73-84, 1998.
5. Baxter RC, Dai J. Purification and characterisation of the acid-labile subunit of rat serum insulin-like growth factor binding protein complex. Endocrinology 134: 848-852, 1994.
6. Bick T, Hochberg Z, Amit T, Isaksson OG, Jansson JO. Roles of pulsatility and continuity of growth hormone (GH) administration in the regulation of hepatic GH-receptors, and circulating GH-binding protein and insulin-like growth factor-I. Endocrinology 131: 423-429, 1992.
7. Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology 136: 2099-2109, 1995.
8. Blethen SL, Baptista J, Kuntze J, Foley T, LaFranchi S, Johanson A. Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. The Genentech Growth Study Group. J Clin Endocrinol Metab 82: 418-420, 1997.
9. Cavallo L, De LF, Bernasconi S, Russo R, Zecchino C, Arrigo T. Subcutaneous growth hormone administration in growth-hormone-defi-cient children. Continuous plus pulsatile overnight versus single daily injection: effects on growth rate velocity. Horm Res 42: 86-89, 1994.
10. Chandrashekar V, Bartke A. The role of growth hormone in the control of gonadotropin secretion in adult male rats. Endocrinology 139: 1067-1074, 1998.
11. Charlton HM, Clark RG, Robinson IC, Porter-Goff AE, Cox BS, Bugnon C, Bloch BS. Growth hormone-deficient dwarfism in the rat: a new mutation. J Endocrinol 119: 51-58, 1988.
12. Choi HK, Waxman DJ. Growth hormone, but not prolactin, maintains, low-level activation of STAT5a and STAT5b in female rat liver. Endocrinology 140: 5126-5135, 1999.
13. Crawford BA, Dobbie P, Bass JJ, Lewitt MS, Baxter RC, Handelsman DJ. Growth hormone (GH) regulation of circulating insulin-like growth factor-I levels during sexual maturation of the GH-deficient dwarf (dw/ dw) male rat. J Endocrinol 141: 393-401, 1994.
14. Daugaard JR, Laustsen JL, Hansen BS, Richter EA. Insulin action in growth hormone-deficient and age-matched control rats: effect of growth hormone treatment. J Endocrinol 160: 127-135, 1999.
15. Davey HW, Xie T, McLachlan MJ, Wilkins RJ, Waxman DJ, Grattan DR. STAT5b is required for GH-induced liver IGF-I gene expression. Endocrinology 142: 3836-3841, 2001.
16. Davies JS, Gevers EF, Stevenson AE, Coschigano KT, El-Kasti MM, Bull MJ, Elford C, Evans BA, Kopchick JJ, Wells T. Adiposity profile in the dwarf rat: an unusually lean model of profound growth hormone deficiency. Am J Physiol Endocrinol Metab 292: E1483-E1494, 2007.
17. De Schepper J, Craen M, Massa G, Heinrichs C, Maes M, Du Caju M, Rausin L, Bourguignon JP. Growth hormone therapy in Turner's syndrome: one versus two daily injections. J Clin Endocrinol Metab 79: 489-494, 1994.
18. Everitt AV, Terry V, Phillips MJ, Kerry HM, Shorey CD. Morphometric analysis of gastocnemius muscle fiber size and fiber proportions in the hypophysectomised rat after prolonged administration of growth hormone or thyroxine. Growth Dev Aging 60: 85-93, 1996.
19. Flores-Morales A, Greenhalgh CJ, Norstedt G, Rico-Bautista E. Negative regulation of growth hormone receptor signaling. Mol Endocrinol 20: 241-253, 2006.
20. Fowelin J, Attvall S, Lager I, Bengtsson BA. Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism 42: 1443-1447, 1993.
21. Freeth JS, Ayling RM, Whatmore AJ, Towner P, Price DA, Norman MR, Clayton PE. Human skin fibroblasts as a model of growth hormone (GH) action in GH receptor-positive Laron's syndrome. Endocrinology 138: 55-61, 1997.
22. Gargosky SE, Tapanainen P, Rosenfeld RG. Administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I), by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats. Endocrinology 134: 2267-2276, 1994.
23. Gebert CA, Park SH, Waxman DJ. Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation. Mol Endocrinol 13: 213-227, 1999.
24. Gelander L, Blum WF, Larsson L, Rosberg S, Albertsson-Wikland K. Monthly measurements of insulin-like growth factor I (IGF-I) and IGFbinding protein-3 in healthy prepubertal children: characterization and relationship with growth: the 1-year growth study. Pediatr Res 45: 377-383, 1999.
25. Gerbert CA, Park SH, Waxman DJ. Regulation of stat5b activation by the temporal pattern of growth hormone stimulation. Mol Endocrinol 11: 400-414, 1997.
26. Gevers EF, Loveridge N, Robinson IC. Bone marrow adipocytes: a neglected target tissue for growth hormone. Endocrinology 143: 4065-4073, 2002.
27. Gevers EF, Wit JM, Robinson IC. Effect of gonadectomy on growth and GH responsiveness in dwarf rats. J Endocrinol 145: 69-79, 1995.
28. Gevers EF, Wit JM, Robinson IC. Growth, growth hormone (GH)-binding protein, and GH receptors are differentially regulated by peak and trough components of the GH secretory pattern in the rat. Endocrinology 137: 1013-1018, 1996.
29. Gill MS, Thalange NK, Foster PJ, Tillmann V, Price DA, Diggle PJ, Clayton PE. Regular fluctuations in growth hormone (GH) release determine normal human growth. Growth Horm IGF Res 9: 114-122, 1999.
30. Gill MS, Tillmann V, Veldhuis JD, Clayton PE. Patterns of GH output and their synchrony with short term height increments influence stature and growth performance in normal children. J Clin Endocrinol Metab 86: 5860-5863, 2001.
31. Glasscock GF, Hein AN, Miller JA, Hintz RL, Rosenfeld RG. Effects of continuous infusion of insulin-like growth factor I and II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat. Endocrinology 130: 203-210, 1992.
32. Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab 85: 3990-3993, 2000.
33. Guyda HJ. Four decades of growth hormone therapy for short children: what have we achieved? J Clin Endocrinol Metab 84: 4307-4316, 1999.
34. Hayashida T, Contopoulos AN. Immunological studies with rat pituitary growth hormone. I. Basic studies with immunodiffusion and antihormone tests. Gen Comp Endocrinol 9: 217-226, 1967.
35. Hindmarsh PC, Fall CH, Pringle PJ, Osmond C, Brook CG. Peak and trough growth hormone concentrations have different associations with the insulin-like growth factor axis, body composition and metabolic parameters. J Clin Endocrinol Metab 82: 2172-2176, 1997.
36. Jansson JO, Eden S, Isaksson OG. Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 6: 128-150, 1985.
37. Jørgensen JO, Thuesen L, Müller J, Ovesen P, Skakkebaek NE, Christiansen JS. Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance. Eur J Endocrinol 130: 224-228, 1994.
38. Kemp SF, Fielder PJ, Attie KM, Blethen SL, Reiter EO, Ford KM, Marian M, Dao LN, Lee HJ, Saenger P. Pharmacokinetic and pharmacodynamic characteristics of a long-acting growth hormone (GH) preparation (nutropin depot) in GH-deficient children. J Clin Endocrinol Metab 89: 3234-3240, 2004.
39. Labarta JI, Gargosky SE, Simpson DM, Lee PD, Argente J, Guevara-Aguirre J, Rosenfeld RG. Immunoblot studies of the acid-labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long-term therapy with GH or IGF-I respectively. Clin Endocrinol (Oxf) 47: 657-666, 1997.
40. Laursen T, Jørgensen JO, Christiansen JS. Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults. Clin Endocrinol (Oxf) 41: 337-343, 1994.
41. Lewitt MS, Saunders H, Phuyal JL, Baxter R. Complex formation by human insulin-like growth factor binding protein-3 and human acid-labile subunit in growth hormone-deficient rats. Endocrinology 134: 2404-2409, 1994.
42. Maiter D, Underwood LE, Maes M, Davenport ML, Ketelslegers JM. Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor I and liver GH receptors in hypophysectomized rats. Endocrinology 123: 1053-1059, 1988.
43. Martinez DA, Orth MW, Carr KE, Vanderby R, Jr, Vailas AC. Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone. Am J Physiol Endocrinol Metab 270: E51-E59, 1996.
44. Miquet JG, Sotelo AI, Bartke A, Turyn D. Desensitization of the JAK2/STAT5 GH signaling pathway associated with increased CIS protein content in liver of pregnant mice. Am J Physiol Endocrinol Metab 289: E600-E607, 2005.
45. O'Neal DN, Kalfas A, Dunning PL, Christopher MJ, Sawyer SD, Ward GM, Alford FP. The effect of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis. J Clin Endocrinol Metab 79: 975-983, 1994.
46. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC. Growth hormone and bone. Endocr Rev 19: 55-79, 1998.
47. Ooi G, Cohen FJ, Tseng LY, Rechler MM, Boisclair Y. Growth hormone stimulates transcription of the gene encoding the acid-labile subunit (ALS) of the circulating insulin-like growth factor binding protein complex and ALS promoter activity in rat liver. Mol Endocrinol 11: 997-1007, 1997.
48. Papaconstantinou J, Deford JH, Gerstner A, Hsieh CC, Boylston WH, Guigneaux MM, Flurkey K, Harrison DE. Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice. Mech Ageing Dev 126: 692-704, 2005.
49. Phillip M, Hershkovitz E, Belotserkovsky O, Leiberman E, Limoni Y, Zadik Z. Once versus twice daily injections of growth hormone in children with idiopathic short stature. Acta Paediatr 87: 518-520, 1998.
50. Robinson KA, Willi SM, Bingel S, Buse MG. Decreased hexosamine biosynthesis in GH-deficient dwarf rat muscle. Reversal with GH, but not IGF-I, therapy. Am J Physiol Endocrinol Metab 276: E435-E442, 1999.
51. Singleton DA, Buschang PH, Behrents RG, Hinton RJ. Craniofacial growth in growth hormone-deficient rats after growth hormone supplementation. Am J Orthod Dentofacial Orthop 130: 69-82, 2006.
52. Skottner A, Clark RG, Fryklund L, Robinson IC. Growth responses in a mutant dwarf rat to human growth hormone and recombinant human insulin-like growth factor I. Endocrinology 124: 2519-2526, 1989.
53. Stiles AD, D'Ercole AJ. The insulin-like growth factors and the lung. Am J Respir Cell Mol Biol 3: 93-100, 1990.
54. Suttie JM, Fennessy PF, Corson ID, Laas FJ, Crosbie SF, Butler JH, Gluckman PD. Pulsatile growth hormone, insulin-like growth factors and antler development in red deer (Cervus elaphus scoticus) stags. J Endocrinol 121: 351-360, 1989.
55. Tannenbaum GS, Martin JB, Colle E. Ultradian growth hormone rhythm in the rat: effects of feeding, hyperglycemia, and insulin-induced hypoglycemia. Endocrinology 99: 720-727, 1976.
56. Thalange NK, Gill MS, Gill L, Whatmore AJ, Addison GM, Price DA, Clayton PE. Infradian rhythms in urinary growth hormone excretion. J Clin Endocrinol Metab 81: 100-106, 1996.
57. Tolle V, Bassant MH, Zizzari P, Poindessous-Jazat F, Tomasetto C, Epelbaum J, Bluet-Pajot MT. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 143: 1353-1361, 2002.
58. Veldhuis JD, Carlson ML, Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686-7690, 1987.
59. Woelfle J, Chia DJ, Rotwein P. Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GHinduced insulin-like growth factor-I gene activation. J Biol Chem 278: 51261-51266, 2003.