Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 11, 1999, Pages 4118-4126

  Aguiar Oliveira, Manuel H ^b   Gill, Matthew S ^a   Barretto, Elenilde S De A ^b   Alcântara, Marta R S ^b   Miraki Moud, Farideh ^d   Menezes, Carlos A ^b   Souza, Anita H O ^b   Martinelli, Carlos E ^c   Pereira, F A ^b   Salvatori, Roberto ^e   Levine, Michael A ^e   Shalet, Stephen M ^f   Camacho Hubner, Cecilia ^d   Clayton, Peter E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RELEASING FACTOR RECEPTOR; PROTEIN; PROTEIN SUBUNIT; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; COMPLEX FORMATION; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; FEMALE; GENE MUTATION; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION;

EID: 0033304486     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.11.4118     Document Type: Article

References (40)

1. The diagnosis of growth hormone deficiency in children and adults
2. Is growth hormone deficiency a viable diagnosis?
3. Diagnostic controversy: The diagnosis of childhood growth hormone deficiency revisited
4. Hazards of pharmacological tests of growth hormone secretion in childhood
5. Growth hormone state after completion of treatment with growth hormone
6. The prevalence of severe growth hormone deficiency in adults who received growth hormone replacement in childhood
7. Insulin-like growth factors I and II in evaluation of growth retardation
8. Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma
9. A specific radioimmunoassay for insulin-like growth factor II: The interference of IGF binding proteins can be blocked by excess IGF-I
10. Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency
11. Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency?
12. Biochemical tests in the diagnosis of childhood growth hormone deficiency
13. Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children
14. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: Determination by reconstitution and affinity-labeling
15. Circulating levels and molecular distribution of the acid-labile (α) subunit of the high molecular weight insulin-like growth factor-binding protein complex
16. Acid-labile subunit of human insulin-like growth factor-binding protein complex: Measurement, molecular, and clinical evaluation
17. Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor
18. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse
19. The Dwarfs of Sindh: Severe growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene
20. Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene
21. Cross sectional stature and weight reference curves for the UK, 1990
22. Measurement of insulin-like growth factor-II in human plasma using a specific monoclonal antibody-based two-site immunoradiometric assay
23. The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy
24. Circulating levels of IGFs and IGF binding proteins in human cord serum: Relationships to intrauterine growth
25. Purification and characterization of the insulin-like growth factor-binding protein-1 phosphoform found in normal plasma
26. Modulation of human IGF binding protein-3 activity by structural modification
27. Growth hormone receptor deficiency in Ecuador: Clinical and biochemical phenotype in two populations
28. Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: Relation to age, sex, stage of puberty, testicular size, and body mass index
29. Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: The relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass indent, and pubertal maturation
30. Human growth hormone and human aging
31. Laron syndrome: Typical and atypical forms
32. Variables controlling the secretion cf insulin-like growth factor binding protein-2 in normal human subjects
33. The diagnosis of severe growth hormone deficiency in elderly patients with hypothalamic-pituitary disease
34. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
35. Formation of 150-kDa binary complexes of insulin-like growth factor binding protein-3 and the acid-labile subunit in vitro and in vivo
36. Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit
37. Insulin-like growth factor (IGF)-binding proteins in serum - Do they have additional roles besides modulating the endocrine IGF actions
38. Growth hormone (GH) treatment of GH-deficient children increases serum levels of insulin-like growth factors (IGFs). IGF-binding protein-3 and -5, and bone alkaline phosphatase isoenzyme
39. The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: Hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency
40. Insulin-like growth factor (IGF) binding protein (IGFBP) complex: Epitope mapping, immunoassay and preliminary clinical evaluation