Immunoblot studies of the acid-labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long-term therapy with GH or IGF-I respectively

Clinical Endocrinology

Volumn 47, Issue 6, 1997, Pages 657-666

  Labarta, José I ^a,e   Gargosky, Sharron E ^a   Simpson, Diane M ^a   Lee, Phillip D K ^b   Argente, Jesús ^c   Guevara Aguirre, Jaime ^d   Rosenfeld, Ron G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Diagnostic Systems Laboratories Inc   (United States)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d Inst Endocrinol   (Ecuador)

^e HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

ADOLESCENT; ARTICLE; BODY FLUID; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HORMONE RECEPTOR INTERACTION; HUMAN; IMMUNOBLOTTING; PRIORITY JOURNAL;

EID: 0031470223     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.2581078.x     Document Type: Article

References (52)

1. Ballard, J., Baxter, R., Binoux, M., Clemmons, D., Drop, S., Hall, K., Hintz, R., Rechler, M., Rutanen, E. & Schwander, J. (1992) Report on the nomenclature of the IGF binding proteins. Journal of Clinical Endocrinology and Metabolism, 74, 1215-1216.
2. Barreca, A., Ponzani, P., Arvigo, M., Giordano, G. & Minuto, F. (1998) Effect of the acid-labile subunit on the binding of insulin-like growth factor (IGF)-binding protein-3 to 1251 IGF-I. Journal of Clinical Endocrinology and Metabolism, 80, 1318-1324.
3. Baxter, R.C. (1988) Characterization of the acid-labile subunit of the growth hormone dependent insulin-like growth factor binding protein complex. Journal of Clinical Endocrinology and Metabolism, 67, 265-272.
4. Baxter, R.C. (1990a) Circulating levels and molecular distribution of the acid-labile subunit of the high molecular weight insulin-like growth factor binding protein complex. Journal of Clinical Endocrinology and Metabolism, 70, 1347-1353.
5. Baxter, R.C. (1990b) Glycosaminoglycans inhibit formation of the 140kDa insulin-like growth factor-binding protein complex. Biochemical Journal, 271, 773-777.
6. Baxter, R.C. & Dai, J. (1994) Purification and characterization of the acid-labile subunit of rat serum insulin like growth factor binding protein complex. Endocrinology, 134, 848-852.
7. Baxter, R.C., Hizuka, N., Takano, K., Holman, S.R. & Asakawa, K. (1993) Responses of insulin-like growth factor binding protein-1 (IGFBP-1) and the IGFBP-3 complex to administration of insulin-like growth factor-I. Acta Endocrinologica, 128, 101-108.
8. Baxter, R.C. & Martin, J.L. (1986) Radioimmunoassay of growth hormone dependent insulin-like growth factor binding protein in human plasma. Journal of Clinical Investigation, 78, 1504-1512.
9. Baxter, R.C. & Martin, J.L. (1989) Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity labeling. Proceedings of the National Academy of Sciences USA, 86, 6898-6902.
10. Baxter, R.C., Martin, J.L. & Beniac, V.A. (1989) High molecular weight insulin-like growth factor binding protein complex: purification and properties of the acid-labile subunit from human serum. Journal of Biology and Chemistry, 264, 11843-11848.
11. Berg, M.A., Guevara-Aguirre, J., Rosenbloom, A.L., Rosenfeld, R.G. & Francke, U. (1992) Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome. Human Mutation, 1, 24-34.
12. Binoux, M. & Hossenlopp, P. (1988) Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph. Journal of Clinical Endocrinology and Metabolism, 67, 509-514.
13. Bowsher, R.R., Lee, W.H., Apathy, J.M., O'Brien, P.J., Ferguson, A.L. & Henry, D.P. (1991) Measurement of insulin-like growth factor-II in physiological fluids and tissues. I. An improved extraction procedure and radioimmunoassay for human and rat fluids. Endocrinology, 128, 805-814.
14. Camacho-Hubner, C., Clemmons, D.R. & D'Ercole, J. (1991) Regulation of insulin-like growth (IGF) binding proteins in transgenic mice with altered expression of growth hormone and IGF-I. Endocrinology, 129, 1201-1206.
15. Chin, E., Zhou, J., Dai, J., Baxter, R.C. & Bondy, C.A. (1994) Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex. Endocrinology, 134, 2498-2504.
16. Dai, J. & Baxter, R.C. (1994) Regulation in vivo of the acid-labile subunit of the rat serum insulin-like growth factor-binding protein complex. Endocrinology, 135, 2335-2341.
17. Dai, J., Scott, C.D. & Baxter, R.C. (1994) Regulation of the acid-labile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Endocrinology, 135, 1066-1072.
18. Daughaday, W.H. & Rotwein, P. (1989) Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocrine Reviews, 10, 68-91.
19. De Boer, H., Block, G.J., Popp-Snijders C., Stuurman, L., Baxter, R.C. & Van der Veen, E. (1996) Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers. Journal of Endocrinology and Metabolism, 81, 1371-1377.
20. D'Ercole, A.J., Drop, S.L.S. & Korleve, D.J. (1985) Somatomedin C/ Insulin-like growth factor-I binding proteins in human amniotic fluid and in fetal and postnatal blood: evidence of immunological homology. Journal of Clinical Endocrinology and Metabolism, 61, 612-619.
21. Fielder, P.J., Mortensen, D.L., Mallet, P., Carlsson, B., Baxter, R.C. & Clark, R.G. (1996) Differential long-term effects of insulin-like growth factor-I (IGF-I). growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats. Endocrinology, 137, 1913-1920.
22. Furlanetto, R.W. (1980) The somatomedin C binding protein: evidence for a heterologous subunit structure. Journal of Clinical Endocrinology and Metabolism, 51, 12-19.
23. Gargosky, S.E., Pham, H.M., Wilson, K.F., Liu, F., Giudice, L.C. & Rosenfeld, R.G. (1992) Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. Endocrinology, 131, 3051-3060.
24. Gargosky, S.E., Tapanainen, P. & Rosenfeld, R.G. (1994) administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I), by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats. Endocrinology, 134, 2267-2276.
25. Gargosky, S.E., Wilson, K.F., Fielder, P.J., Vacarello, M.A., Guevara-Aguirre, J., Diamond, F.B., Baxter, R.C., Rosenbloom, A.L. & Rosenfeld, R.G. (1993) The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor deficiency patients: effects of IGF-I therapy on IGFBP-3. Journal of Clinical Endocrinology and Metabolism, 77, 1683-1689.
26. Guevara-Aguirre, J., Vasconez, O., Martinez, V., Martinez, A.L., Rosenbloom, A.L., Diamond, Jr F.B., Gargosky, S.E., Nonoshita, L. & Rosenfeld, R.G. (1995) A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency. Journal of Clinical Endocrinology and Metabolism, 80, 1393-1398.
27. Hardouin, S., Gourmelen, M., Noguiez, P., Seurin, D., Roghani, M., Le Bouc, Y., Povoa, G., Merimee, T.J., Hossenlopp, P. & Binoux, M. (1989) Molecular forms of serum insulin-like growth factor (IGF)-binding proteins in man: relationships with growth hormone and IGFs and physiological significance. Journal of Clinical Endocrinology and Metabolism, 69, 1291-1301.
28. Hasegawa, Y., Cohen, P., Yorgin, P. & Rosenfeld, R.G. (1992) Characterization of urinary insulin-like growth factor binding proteins. Journal of Clinical Endocrinology and Metabolism, 74, 830-835.
29. Hintz, R.L. & Liu, F. (1980) Somatomedin plasma binding proteins. In: Growth Hormone and Other Biologically Active Peptides. (eds A. Pecile & E.E. Müller), pp. 133-143. Excerpta Medica, Amsterdam.
30. Jones, J.I. & Clemmons, D.R. (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocrine Reviews, 16, 3-34.
31. Kupfer, S.R., Underwood, L.E., Baxter, R.C. & Clemmons, D.R. (1993) Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. Journal of Clinical Investigation, 91, 391-396.
32. Lamson, G., Giudice, L.G. & Rosenfeld, R.G. (1991) Insulin-like growth factor binding proteins: structural and molecular relationships. Growth Factors, 5, 19-28.
33. Laron, Z., Perzelan, A. & Karp, M. (1968) Pituitary dwarfism with high serum levels of growth hormone. Israel Journal of Medical Sciences, 4, 883-894.
34. Laron, Z., Perzelan, A. & Manneheimer, S. (1966) Genetic pituitary dwarfism with high serum concentration of growth hormone: a new inborn error of metabolism? Israel Journal of Medical Sciences, 2, 152-155.
35. Lee, Y.C. & Rochler, M.M. (1995) A major portion of the 150-kilodalton insulin-like growth factor binding protein (IGFBP) complex in adult rat serum contains unoccupied, proteolytically nicked IGFBP-3 that binds IGF-II preferentially. Endocrinology, 136, 668-678.
36. Leong, S.L., Baxter, R.C., Camerato, T., Dai, J. & Wood, W.I. (1992) Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. Molecular Endocrinology, 6, 870-876.
37. Lewitt, M.S., Saunders, H. & Baxter, R.C. (1993) Bioavailability of insulin-like growth factors (IGFs) in rats determined by the molecular distribution of human IGF-binding protein-3. Endocrinology, 133, 1797-1802.
38. Lewitt, M.S., Saunders, H., Phuyal, J.L. & Baxter, R.C. (1994) Complex formation by human insulin-like growth factor-binding protein-3 and human acid-labile subunit in growth hormone deficient rats. Endocrinology, 134, 2404-2409.
39. Liu, F., Hintz, R.L., Khare, A., Diaugustine, R.P., Powell, D.R. & Lee, P.D.K. (1994) Immunoblot studies of the IGF-related acid-labile subunit. Journal of Clinical Endocrinology and Metabolism, 79, 1883-1886.
40. Martin, J.L. & Baxter, R.C. (1985) Antibody against acid-stable insulin-like growth factor binding protein detects 150,000 mol wt growth hormone-dependent complex in human plasma. Journal of Clinical Endocrinology and Metabolism, 61, 799-801.
41. Martin, J.L. & Baxter, R.C. (1986) Insulin-like growth factor binding proteins from human plasma: purification and characterization. Journal of Biology and Chemistry, 261, 8754-8760.
42. Matsumoto, T., Gargosky, S.E., Iwasaki, K. & Rosenfeld, R.G. (1996) Identification and characterization of insulin like growth factors (GFs), IGF-binding proteins, and IGFBP proteases in human synovial fluid. Journal of Clinical Endocrinology and Metabolism, 81, 150-155.
43. Rechler, M.M. (1993) Insulin-like growth factor binding proteins. Vitamins and Hormones, 47, 1-114.
44. Rosenfeld, R.G., Lamson, G.L., Pham, H., Oh, Y., Conover, C., DeLeon, D.D., Donovan, S.M., Ocrant, I. & Giudice, L.C. (1991) Insulin-like growth factor binding proteins. Recent Progress in Hormone Research, 46, 99-159.
45. Rosenfeld, R.G., Pham, H., Oh, Y., Lamson, G. & Giudice, L. (1990) Identification of insulin-like growth factor binding protein-2 (IGFBP-2) and low molecular weight IGFBP in human seminal plasma. Journal of Clinical Endocrinology and Metabolism, 70, 551-553.
46. Rosenfeld, R.G., Rosenbloom, A.L. & Guevara-Aguirre, J. (1994) Growth hormone (GH) insensitivity due to primary GH receptor deficiency. Endocrine Reviews, 15, 369-390.
47. Scott, C.D. & Baxter, R.C. (1991) Synthesis of the acid-labile subunit of the growth hormone-dependent insulin-like factor-binding protein complex by rat hepatocytes in culture. Biochemical Journal, 275, 441-446.
48. Towbin, H., Staehlin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from acrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences USA, 76, 4350-4354.
49. Walker, J.L., Baxter, R.C., Young, S., Pucilowska, J., Clemmons, D.R. & Underwood, L.F., (1993) Effects of recombinant insulin-like growth factor-I on IGF binding proteins and the acid-labile subunit in growth hormone insensitivity syndrome. Growth Regulation, 3, 109-112.
50. Wilson, K.P., Fielder, P.J., Guevara-Aguirre, J., Cohen, P., Vasconez, O., Martinez, V., Martinez, A., Rosembloom, A.I., & Rosenfeld, R.G. (1995) Long term effects of insulin-like growth factor (IGF)-I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency. Clinical Endocrinology, 42, 399-407.
51. Xu, S., Cwyfan-Hughes, S.C., Van der Klappen, J.W.J., Sansom, J., Burton, J.L., Donnelly, M. & Holly, J.M.P. (1995) Insulin-like growth factors (IGFs) and IGF-binding proteins in human skin interstitial fluid. Journal of Clinical Endocrinology and Metabolism, 80, 2940-2945.
52. Zapf, J., Hauri, C., Waldvogel, M., Futo, F., Häsler, H., Binz, K., Guler, H.P., Schmid, C. & Froech, E.R. (1989) Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats. Proceedings of the National Academy of Sciences USA, 86, 3813-3817.