Large-scale asymmetric synthesis of a cathepsin S inhibitor

Journal of Organic Chemistry

Volumn 75, Issue 4, 2010, Pages 1155-1161

  Lorenz, Jon C ^a   Busacca, Carl A ^a   Feng, XuWu ^a   Grinberg, Nelu ^a   Haddad, Nizar ^a   Johnson, Joe ^a   Kapadia, Suresh ^a   Lee, Heewon ^a   Saha, Anjan ^a   Sarvestani, Max ^a   Spinelli, Earl M ^a   Varsolona, Rich ^a   Wei, Xudong ^a   Zeng, Xingzhong ^a   Senanayake, Chris H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-HYDROXYPYRIDINE; ASYMMETRIC HYDROGENATION; ASYMMETRIC SYNTHESIS; CHEMICAL EQUATIONS; CHIRAL UREAS; CYSTEINE PROTEASE; FUNCTIONALIZED; PEPTIDE COUPLING; PHOSPHONATION; SCALE-UP; STRECKER REACTIONS; SYNTHETIC ROUTES;

ALDEHYDES; CHROMATOGRAPHIC ANALYSIS; HYDROGENATION; METABOLISM; PALLADIUM; REACTION INTERMEDIATES; UREA;

SYNTHESIS (CHEMICAL);

ALDEHYDE; AMIDONITRILE; CATHEPSIN S; CATHEPSIN S INHIBITOR; CYSTEINE PROTEINASE; PALLADIUM; RHODIUM; UNCLASSIFIED DRUG; UREA; VINYL DERIVATIVE;

ARTICLE; ASYMMETRIC SYNTHESIS; CALORIMETRY; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; HYDROGENATION; OLEFINATION; PROTON NUCLEAR MAGNETIC RESONANCE; THERMOSTABILITY;

ALKENES; CALORIMETRY; CATALYSIS; CATHEPSINS; CYCLIZATION; ENZYME INHIBITORS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PALLADIUM; RHODIUM; STEREOISOMERISM; UREA; VINYL COMPOUNDS;

EID: 77249177535     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo9022809     Document Type: Article

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