A comparison of catalysts to promote imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst

Organic Process Research and Development

Volumn 9, Issue 6, 2005, Pages 956-961

  Dunn, Peter J ^a   Hoffmann, Wilfried ^a   Kang, Ying ^a,b   Mitchell, John C ^b   Snowden, Martin J ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 28944443142     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0580062     Document Type: Article

References (18)

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11. See MSDS, Applied Biosystems, July 2002.
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13. Yoshida, T. Kogyyo Kayaku 1987, 5, 311-316 (in Japanese).
14. Wehrstedt, K.; Heitkamp D. 1-Hydroxybenzotriazole (HOBt) and Similar Compounds: Properties and Classification; OECD-IGUS Energetic and Oxidising Substances (EOS) Working Group Meeting, Paris, France, March 2002. This information can be found on http://www.bam.de/english/ index4.htm. In addition it is reported that anhydrous HOBt is more dangerous than the hydrate of HOBt.
15. Unfortunately a further reminder of the potential hazards of handling this material on a large scale was demonstrated by a recent explosion at Lacamas Laboratories, Portland, Oregon, U.S.A., which was caused by 1-hydroxybenzotriazole. The incident took place on May 9, 2005.
16. Note that this material has recently become available as a 0.5-0.7 M solution in DMF from the Sigma-Aldrich company and other suppliers.
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