Involvement of Rho kinase in the pathogenesis of acute pulmonary embolism-induced polystyrene microspheres in rats

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 3, 2010, Pages

  Toba, M ^a   Nagaoka, T ^a   Morio, Y ^a   Sato, K ^a   Uchida, K ^a   Homma, N ^a   Takahashi, K ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Endothelial nitric oxide synthase; Endothelin 1; Rho kinase ; Vascular cell adhesion molecule 1

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FASUDIL; POLYSTYRENE; RHO KINASE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; CONTROLLED STUDY; HEART RIGHT VENTRICLE PRESSURE; HYPOXEMIA; LUNG ALVEOLUS OXYGEN TENSION; LUNG EMBOLISM; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; ENDOTHELIN-1; HEMODYNAMICS; INJECTIONS, INTRAVENOUS; LUNG; MALE; MICROSPHERES; NITRIC OXIDE SYNTHASE TYPE III; POLYSTYRENES; PROTEIN KINASE INHIBITORS; PULMONARY ARTERY; PULMONARY EMBOLISM; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 77249159372     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90237.2008     Document Type: Article

References (48)

1. British Thoracic Society. Guidelines for the management of suspected acute pulmonary embolism. Thorax 58: 470-483, 2003.
2. Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, Takeshit A. Longterm treatment with a Rho-kinase inhibitor improves monocrotalineinduced fatal pulmonary hypertension in rats. Circ Res 94: 385-393, 2004.
3. Ahmed A. American College of Cardiology/American Heart Association Chronic Heart Failure Evaluation and Management guidelines: relevance to the geriatric practice. J Am Geriatr Soc 51: 123-126, 2003.
4. Ayach B, Tsang J, Jeng AY, Blouin A, Gosselin M, Wang FH, Wu-Wong JR, Wessale J, Opgenorth TJ, Battistini B. Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism. Clin Sci (Lond) 103, Suppl 48: 371S-375S, 2002.
5. Barritt DW, Jordan SC. Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial. Lancet 1: 1309-1312, 1960.
6. Bauer M, Wilkens H, Langer F, Schneider SO, Lausberg H, Schafers HJ. Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension. Circulation 105: 1034-1036, 2002.
7. Becattini C, Agnelli G, Pesavento R, Silingardi M, Poggio R, Taliani MR, Ageno W. Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest 130: 172-175, 2006.
8. Dalen JE, Alpert JS. Natural history of pulmonary embolism. Prog Cardiovasc Dis 17: 259-270, 1975.
9. Dantzker DR, Bower JS. Alterations in gas exchange following pulmonary thromboembolism. Chest 81: 495-501, 1982.
10. de Perrot M, Fadel E, McRae K, Tan K, Slinger P, Paul N, Mak S, Granton JT. Evaluation of persistent pulmonary hypertension after acute pulmonary embolism. Chest 132: 780-785, 2007.
11. Dismuke SE, Wagner EH. Pulmonary embolism as a cause of death. The changing mortality in hospitalized patients. JAMA 255: 2039-2042, 1986.
12. Fagan KA, Fouty BW, Tyler RC, Morris KG Jr, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, Rodman DM. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299, 1999.
13. Fagan KA, McMurtry IF, Rodman DM. Role of endothelin-1 in lung disease. Respir Res 2: 90-101, 2001.
14. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287: L656-L664, 2004.
15. Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 22: 32-39, 2001.
16. Fukumoto Y, Matoba T, Ito A, Tanaka H, Kishi T, Hayashidani S, Abe K, Takeshita A, Shimokawa H. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 91: 391-392, 2005.
17. Garcia Szabo RR, Minnear FL, Bizios R, Johnson A, Malik AB. Role of thromboxane in the pulmonary response to pulmonary microembolization. Chest 83: 76S-78S, 1983.
18. Ghuysen A, Lambermont B, Dogne JM, Kolh P, Tchana-Sato V, Morimont P, Magis D, Hanson J, Segers P, D'Orio V. Effect of BM-573 [N-terbutyl- N′-[2-(4′-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism. J Pharmacol Exp Ther 310: 964-972, 2004.
19. Goldhaber SZ, Elliott CG. Acute pulmonary embolism: part I: epidemiology, pathophysiology, and diagnosis. Circulation 108: 2726-2729, 2003.
20. Homma N, Morio Y, Takahashi H, Yamamoto A, Suzuki T, Sato K, Muramatsu M, Fukuchi Y. Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension. Respiration 73: 105-112, 2006.
21. Itti E, Nguyen S, Robin F, Desarnaud S, Rosso J, Harf A, Meignan M. Distribution of ventilation/perfusion ratios in pulmonary embolism: an adjunct to the interpretation of ventilation/perfusion lung scans. J Nucl Med 43: 1596-1602, 2002.
22. Kobayashi N, Mita S, Yoshida K, Honda T, Kobayashi T, Hara K, Nakano S, Tsubokou Y, Matsuoka H. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-kappaB induced by oxidative stress. Hypertension 42: 1004-1013, 2003.
23. Lee JH, Chun YG, Lee IC, Tuder RM, Hong SB, Kim WS, Kim DS, Kim WD, Lee SD. Pathogenic role of endothelin 1 in hemodynamic dysfunction in experimental acute pulmonary thromboembolism. Am J Respir Crit Care Med 164: 1282-1287, 2001.
24. Li L, Crockett E, Wang DH, Galligan JJ, Fink GD, Chen AF. Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension. Arterioscler Thromb Vasc Biol 22: 249-255, 2002.
25. McGoon MD, Vanhoutte PM. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. J Clin Invest 74: 828-833, 1984.
26. Morio Y, Homma N, Takahashi H, Yamamoto A, Nagaoka T, Sato K, Muramatsu M, Fukuchi Y. Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs. J Vasc Res 44: 325-335, 2007.
27. Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, Kaibuchi K, Takeshita A. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J 15: 1062-1064, 2001.
28. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171: 494-499, 2005.
29. Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol 100: 996-1002, 2006.
30. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M. Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287: L665-L672, 2004.
31. Naseem KM. The role of nitric oxide in cardiovascular diseases. Mol Aspects Med 26: 33-65, 2005.
32. Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, Voelkel NF, McMurtry IF. Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res 100: 923-929, 2007.
33. Oka M, Ohnishi M, Takahashi H, Soma S, Hasunuma K, Sato K, Kira S. Altered vasoreactivity in lungs isolated from rats exposed to nitric oxide gas. Am J Physiol Lung Cell Mol Physiol 271: L419-L424, 1996.
34. 2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 275: 21722-21729, 2000.
35. Schmeck J, Koch T, Patt B, Heller A, Neuhof H, van Ackern K. The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs. Intensive Care Med 24: 605-611, 1998.
36. Shibuya M, Suzuki Y, Sugita K, Saito I, Sasaki T, Takakura K, Nagata I, Kikuchi H, Takemae T, Hidaka H, Nakashima M. Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg 76: 571-577, 1992.
37. Shimokawa H, Hiramori K, Iinuma H, Hosoda S, Kishida H, Osada H, Katagiri T, Yamauchi K, Yui Y, Minamino T, Nakashima M, Kato K. Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. J Cardiovasc Pharmacol 40: 751-761, 2002.
38. Simon M, Battistini B, Joo Kim Y, Tsang J. Plasma levels of endothelin-1, big endothelin-1 and thromboxane following acute pulmonary air embolism. Respir Physiol Neurobiol 138: 97-106, 2003.
39. Smulders YM. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res 48: 23-33, 2000.
40. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185, 2000.
41. Souza-Costa DC, Figueiredo-Lopes L, Alves-Filho JC, Semprini MC, Gerlach RF, Cunha FQ, Tanus-Santos JE. Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9. Crit Care Med 35: 239-245, 2007.
42. Tokuyama K, Nishimura H, Iizuka K, Kato M, Arakawa H, Saga R, Mochizuki H, Morikawa A. Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. Pharmacology 64: 189-195, 2002.
43. Tsang JY, Lamm WJ, Neradilek B, Polissar NL, Hlastala MP. Endothelin receptor blockade does not improve hypoxemia following acute pulmonary thromboembolism. J Appl Physiol 102: 762-771, 2007.
44. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 276: L297-L303, 1999.
45. Utsunomiya T, Krausz MM, Shepro D, Hechtman HB. Prostaglandin control of plasma and platelet 5-hydroxytryptamine in normal and embolized animals. Am J Physiol Heart Circ Physiol 241: H766-H771, 1981.
46. Vanhoutte PM. Say NO to ET. J Auton Nerv Syst 81: 271-277, 2000.
47. Wolde M, Tulevski I, Mulder J, Boomsma F, Mulder B, Buller H. Brain natriuretic peptide as a predictor of adverse outcome in patients with pulmonary embolism. Circulation 107: 2082-2084, 2003.
48. Zagorski J, Debelak J, Gellar M, Watts JA, Kline JA. Chemokines accumulate in the lungs of rats with severe pulmonary embolism induced by polystyrene microspheres. J Immunol 171: 5529-5536, 2003.