Endothelin receptor blockade does not improve hypoxemia following acute pulmonary thromboembolism

Journal of Applied Physiology

Volumn 102, Issue 2, 2007, Pages 762-771

  Tsang, John Y C ^a,d   Lamm, Wayne J E ^b   Neradilek, Blazej ^c   Polissar, Nayak L ^c   Hlastala, Michael P ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Mountain Whisper Light Statistical Consulting   (United States)

^d ST PAUL S HOSPITAL   (Canada)

Author keywords

Cluster analysis; Fluorescent microspheres; Gas exchange; Regional blood flow; Regional ventilation

Indexed keywords

ENDOTHELIN; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; TEZOSENTAN;

ACUTE PULMONARY THROMBOEMBOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD CLOT; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL MODEL; HYPOTENSION; HYPOXEMIA; LUNG BLOOD FLOW; LUNG EMBOLISM; LUNG GAS EXCHANGE; LUNG VENTILATION; LUNG VENTILATION PERFUSION RATIO; NEWBORN; NONHUMAN; PHARMACOLOGICAL BLOCKING; PIGLET; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RECEPTOR BLOCKING;

ACUTE DISEASE; ANIMALS; ANOXEMIA; DISEASE MODELS, ANIMAL; IMAGING, THREE-DIMENSIONAL; LUNG; MICROSPHERES; PULMONARY EMBOLISM; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; PYRIDINES; RECEPTORS, ENDOTHELIN; REGIONAL BLOOD FLOW; SWINE; TETRAZOLES; VASODILATOR AGENTS; VENTILATION-PERFUSION RATIO;

EID: 33846856937     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01139.2005     Document Type: Article

References (32)

1. Altemeier W, Robertson H, Glenny R. Pulmonary gas exchange analysis by using simulaneous depostion of aerosolized and injected microspheres. J Appl Physiol 85: 2344-2351, 1998.
2. Battistini B, Dussault P. Biosynthesis, distribution and metabolism of endothelins in the pulmonary system. Pulm Pharmacol 11: 79-88, 1998.
3. Benigni A, Remuzzi G. Endothelin antagonists. Lancet 353: 133-138, 1999.
4. Bottinger B, Motsch J, Dorsan J, Mieck U, Gries A, Weimann J, Martin E. Inhaled nitric oxide selectively decreases pulmonary artery pressure and pulmonary vascular resistance following acute massive pulmonary microembolism in piglets. Chest 110: 1041-1047, 1996.
5. Capellier G, Jacques T, Balvay P, Blasco G, Belle E, Barale F. Inhaled nitric oxide in patients with pulmonary embolism. Intensive Care Med 23: 1089-1092, 1997.
6. Clark J, Benjamin N, Larkin S, Webb D, Davies G, Maseri A. Endothelin is a potent long-lasting vasoconstrictor in men. Am J Physiol Heart Circ Physiol 257: H2033-H2035, 1989.
7. Clozel M, Ramuz H, Clozel J, Breu V, Loffler B, Coassolo P, Roux S. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 290: 840-846, 1999.
8. Delcroix M, Melot C, Lejeune P, Leeman M, Naeje R. Effects of vasodilators on gas exchange in acute canine embolic pulmonary hypertension. Anaesthesiology 72: 77-84, 1990.
9. Dschietzig T, Laule M, Alexiou K, Schror K, Baumann G, Stangl K. Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction. Crit Care Med 26: 510-517, 1998.
10. Fields C, Makhoul R. Vasomotor tone and the role of nitric oxide. Semin Vasc Surg 11: 181-192, 1998.
11. Gårdeback M, Larsen F, Rådegran K. Nitric oxide improves hypoxaemia following reperfusion oedema after pulmonary thromboendarterectomy. Br J Anaesth 75: 798-800, 1995.
12. Glenny R, Bernard S, Brinkley M. Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol 74: 2585-2597, 1993.
13. Gries A, Bottiger B, Dorsam J, Bauer H, Weimann J, Bode C, Martin E, Motsch J. Inhaled nitric oxide inhibits platelet aggregation after pulmonary embolism in pigs. Anesthesiology 86: 387-393, 1997.
14. Haendler B, Hechler U, Schleuning WD. Molecular cloning of human endothelin (ET) receptors ETA and ETB. J Cardiovasc Pharmacol 20: S1-S4, 1992.
15. Henry P. Endothelin receptor distribution and function in the airways. Clin Exp Pharmacol Physiol 26: 162-167, 1999.
16. Karaki H, Sudjarwo S, Hori M, Takai M, Urade Y, Okada T. Induction of endothelium-dependent relaxation in the rat aorta by IRL 1620, a novel and selective agonist at the endothelin ETB receptor. Br J Pharmacol 109: 486-490, 1993.
17. Lee J, Chun Y, Lee I, Tuder R, Hong S, Shim T, Lim C, Koh Y, Kim W, Kim D, Kim W, Lee S. Pathogenic role of endothelin 1 in hemodynamic dysfunction in experimental acute pulmonary thromboembolism. Am J Respir Crit Care Med 164: 1282-1287, 2001.
18. Levy S, Simmons D. Redistribution of alveolar ventilation following pulmonary thromboembolism in the dog. J Appl Physiol 36: 60-68, 1974.
19. Masaki T. The discovery of endothelins. Cardiovasc Res 39: 530-533, 1998.
20. Matsuda H, Beppu S, Ohmori F, Yamada M, Miyatake K. Involvement of cyclo-oxygenase-generated vasodilating eicosanoid(s) in addition to nitric oxide in endothelin-1-induced endothelium-dependent vasorelaxation in guinea pig aorta. Heart Vessels 8: 121-127, 1993.
21. Melot C, Delcroix M, Closset J, Vanderhoeft P, Lejeune P, Leeman M, Naeije R. Starling resistor vs. distensible vessel models for embolic pulmonary hypertension. Am J Physiol Heart Circ Physiol 268: H817-H827, 1995.
22. Michael J, Markewitz B. Endothelins and the lung. Am J Respir Crit Care Med 154: 555-581, 1996.
23. Robertson H, Glenny R, Stanford D, McInnes L, Luchtel D, Covert D. High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres. J Appl Physiol 82: 943-953, 1997.
24. Schmeck J, Koch T, Patt B, Heller A, Neuhof H, van Ackern K. The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs. Intensive Care Med 24: 605-611, 1998.
25. Simon M, Battistini B, Kim Y, Tsang J. Plasma levels of endothelin-1, big endothelin-1 and thromboxane following acute pulmonary air embolism. Respir Physiol Neurobiol 138: 97-106, 2003.
26. Sofia M, Faraone S, Alifano M, Micco A, Albisinni R, Maniscalco M, Minno G. Endothelin abnormalities in patients with pulmonary embolism. Chest 111: 544-549, 1996.
27. Sudjarwo S, Hori M, Tanaka T, Matsuda Y, Okada T, Karaki H. Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction. Biochem Biophys Res Commun 200: 627-633, 1994.
28. Tanus-Santos J, Gordo W, Udelsmann A, Cittadino M, Moreno H. Nonselective endothelin-receptor antagonism attenuates hemodynamic changes after massive pulmonary air embolism in dogs. Chest 118: 175-179, 2000.
29. Tsang J, Battistini B, Dussault P, Stewart K, Qayumi K. Biphasic release of immunoreactive endothelins following acute pulmonary thromboembolism. J Cardiovasc Pharmacol 36: S221-S224, 2000.
30. Tsang J, Lamm W, Starr I, Hlastala M. Spatial pattern of ventilation-perfusion mismatch following acute pulmonary thrmboembolism in pigs. J Appl Physiol 99: 662-669, 2005.
31. Tulleken J, Zylstra J, Evers K, van der Werf T. Oxygen desaturation after treatment with inhaled nitric oxide for obstructive shock due to massive pulmonary embolism. Chest 112: 296-297, 1997.
32. Uhlig S, von Bethmann A, Featherstone R, Wendel A. Pharmacologic characterization of endothelin receptor responses in the isolated perfused rat lung. Am J Respir Crit Care Med 152: 1449-1460, 1995.