IL-13 promotes the proliferation of rat pancreatic stellate cells through the suppression of NF-κB/TGF-β1 pathway

Biochemical and Biophysical Research Communications

Volumn 393, Issue 1, 2010, Pages 61-65

  Shinozaki, Satoshi ^a   Mashima, Hirosato ^b   Ohnishi, Hirohide ^b   Sugano, Kentaro ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic pancreatitis; Fibrosis; Interleukin 13; Pancreatic stellate cell (PSC); Proliferation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; STAT6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYSTIC FIBROSIS; FIBROGENESIS; NONHUMAN; PANCREAS CELL; PANCREAS STELLATE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSCRIPTOMICS;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; FIBROSIS; HUMANS; INTERLEUKIN-13; NF-KAPPA B; PANCREAS; PANCREATITIS, CHRONIC; PROMOTER REGIONS, GENETIC; RATS; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS;

EID: 77249152140     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.078     Document Type: Article

References (34)

1. Chiaramonte M.G., Mentink-Kane M., Jacobson B.A., et al. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J. Exp. Med. 197 (2003) 687-701
2. de Lalla C., Galli G., Aldrighetti L., et al. Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis. J. Immunol. 173 (2004) 1417-1425
3. Fuss I.J., Heller F., Boirivant M., et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113 (2004) 1490-1497
4. Hasegawa M., Fujimoto M., Kikuchi K., et al. Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis. J. Rheumatol. 24 (1997) 663-665
5. Ray A., and Cohn L. Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J. Clin. Invest. 104 (1999) 985-993
6. Fichtner-Feigl S., Strober W., Kawakami K., et al. IL-13 signaling through the IL-13[alpha]2 receptor is involved in induction of TGF-[beta]1 production and fibrosis. Nat. Med. 12 (2006) 99-106
7. Wynn T.A. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol. 4 (2004) 583-594
8. Chiaramonte M.G., Donaldson D.D., Cheever A.W., et al. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104 (1999) 777-785
9. Lee C.G., Homer R.J., Zhu Z., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor b1. J. Exp. Med. 194 (2001) 809-822
10. Kelly-Welch A.E., Hanson E.M., Boothby M.R., et al. Interleukin-4 and interleukin-13 signaling connections maps. Science 300 (2003) 1527-1528
11. Apte M.V., Haber P.S., Applegate T.L., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43 (1998) 128-133
12. Mews P., Phillips P., Fahmy R., et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 50 (2002) 535-541
13. Phillips P.A., Wu M.J., Kumar R.K., et al. Cell migration: a novel aspect of pancreatic stellate cell biology. Gut 52 (2003) 677-682
14. Shinozaki S., Ohnishi H., Hama K., et al. Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane. J. Cell. Physiol. 216 (2008) 38-46
15. Apte M.V., Haber P.S., Darby S.J., et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 44 (1999) 534-541
16. Ohnishi H., Ernst S.A., Yule D.I., et al. Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen granules is involved in calcium-regulated amylase secretion. J. Biol. Chem. 272 (1997) 16056-16061
17. Kanamaru C., Yasuda H., Takeda M., et al. Smad7 is induced by norepinephrine and protects rat hepatocytes from activin A-induced growth inhibition. J. Biol. Chem. 276 (2001) 45636-45641
18. Kim S.J., Jeang K.T., Glick A.B., et al. Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction. J. Biol. Chem. 264 (1989) 7041-7045
19. Ohmori Y., and Hamilton T.A. Interleukin-4/STAT6 represses STAT1 and NF-kappa B-dependent transcription through distinct mechanisms. J. Biol. Chem. 275 (2000) 38095-38103
20. Kruse M.-L., Hildebrand P.B., Timke C., et al. TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul. Pept. 90 (2000) 47-52
21. Baldwin A.S. THE NF-κB and I-κB proteins: new discoveries and insights. Annu. Rev. Immunol. 14 (1996) 649-681
22. Lentsch A.B., Shanley T.P., Sarma V., et al. In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13. J. Clin. Invest. 100 (1997) 2443-2448
23. Lan Y., Zhou Q., and Wu Z.L. NF-kappa B involved in transcription enhancement of TGF-beta 1 induced by Ox-LDL in rat mesangial cells. Chin. Med. J. 117 (2004) 225-230
24. Zhu Z., Homer R.J., Wang Z., et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103 (1999) 779-788
25. McKenzie G.J., Emson C.L., Bell S.E., et al. Impaired development of Th2 cells in IL-13-deficient mice. Immunity 9 (1998) 423-432
26. Hershey G.K.K. IL-13 receptors and signaling pathways: an evolving web. J. Allergy Clin. Immunol. 111 (2003) 677-690
27. Murata T., Husain S.R., Mohri H., et al. Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway. Int. Immunol. 10 (1998) 1103-1110
28. Blomhoff R., and Wake K. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 5 (1991) 271-277
29. Friedman S.L. Liver fibrosis - from bench to bedside. J. Hepatol. 38 (2003) 38-53
30. Kaviratne M., Hesse M., Leusink M., et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent. J. Immunol. 173 (2004) 4020-4029
31. Fichtner-Feigl S., Strober W., Kawakami K., et al. IL-13 signaling through the IL-13a2 receptor is involved in induction of TGF-β1 production and fibrosis. Nat. Med. 12 (2006) 99-106
32. Sugimoto R., Enjoji M., Nakamuta M., et al. Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cells. Liver Int. 25 (2005) 420-428
33. Blease K., Schuh J.M., Jakubzick C., et al. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am. J. Pathol. 160 (2002) 481-490
34. Webb D.C., Mahalingam S., Cai Y., et al. Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity. Eur. J. Immunol. 33 (2003) 3377-3385