Quantitative plasma biomarker analysis in HDI exposure assessment

Annals of Occupational Hygiene

Volumn 54, Issue 1, 2010, Pages 41-54

  Flack, Sheila L ^a   Fent, Kenneth W ^a   Trelles Gaines, Linda G ^a   Thomasen, Jennifer M ^a   Whittaker, Steve ^b   Ball, Louise M ^a   Nylander French, Leena A ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b Local Hazardous Waste Management Program   (United States)

Author keywords

1,6 hexamethylene diamine (HDA); 1,6 hexamethylene diisocyanate (HDI); Biomarker; Dermal exposure; Inhalation exposure; Plasma

Indexed keywords

1,6-HEXAMETHYLENE DIAMINE (HDA); BIOLOGICAL SAMPLES; BLOOD COLLECTION; DERMAL EXPOSURE; DIISOCYANATES; EXPOSURE ASSESSMENT; HEXAMETHYLENE DIISOCYANATE; IN-VEHICLE; INHALATION EXPOSURE; OCCUPATIONAL EXPOSURE; PAINT BOOTHS; PERSONAL PROTECTIVE EQUIPMENT; PLASMA SAMPLES; REPAIR SHOPS; SPRAY PAINTERS;

BLOOD; CYCLOHEXANE; HYDROLYSIS; NONVOLATILE STORAGE; PAINT; PLASMAS; PROTECTIVE CLOTHING;

DIRECTIVE ANTENNAS;

1,6 HEXANEDIAMINE; 1,6-DIAMINOHEXANE; 1,6-HEXAMETHYLENE DIISOCYANATE; ALBUMINOID; BIOLOGICAL MARKER; CYANIC ACID DERIVATIVE; DIAMINE; HEMOGLOBIN; HEXAMETHYLENE DIISOCYANATE; PAINT;

AIR POLLUTANT; ARTICLE; BLOOD; CAR; ENVIRONMENTAL MONITORING; EXPOSURE; HUMAN; HYDROLYSIS; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; OCCUPATIONAL EXPOSURE; PROTECTIVE EQUIPMENT; SKIN ABSORPTION; STANDARD; STATISTICAL ANALYSIS; STATISTICAL MODEL; TIME; UTILIZATION REVIEW; WORKPLACE;

AIR POLLUTANTS, OCCUPATIONAL; ALBUMINS; AUTOMOBILES; BIOLOGICAL MARKERS; CYANATES; DATA INTERPRETATION, STATISTICAL; DIAMINES; ENVIRONMENTAL MONITORING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HUMANS; HYDROLYSIS; INHALATION EXPOSURE; LINEAR MODELS; MALE; OCCUPATIONAL EXPOSURE; PAINT; PROTECTIVE DEVICES; SKIN ABSORPTION; TIME FACTORS; WORKPLACE;

EID: 77249139785     PISSN: 00034878     EISSN: 14753162     Source Type: Journal    
DOI: 10.1093/annhyg/mep069     Document Type: Article

References (41)

1. Adams WC. (1993) Measurement of breathing rate and volume in routinely performed daily activities. Prepared for the California Air Resources Board, Contract No. A033-205 Submitted by Human Performance Laboratory. Davis, CA: University of California. Available at http:// www.arb.ca.gov/research/ abstracts/a033-205.htm. Accessed 22 September 2009.
2. Austin S. (2007) Biologicalmonitoring ofTDI-derived amines in polyurethane foamproduction.OccupMed (Lond); 57: 444-448
3. Berode M, Testa B, Savolainen H. (1991) Bicarbonatecatalyzed hydrolysis of hexamethylene diisocyanate to 1,6-diaminohexane. Toxicol Lett; 56: 173-178
4. Brorson T, Skarping G, Nielsen J. (1990a) Biological monitoring of isocyanates and related amines. II. Test chamber exposure of humans to 1,6-hexamethylene diisocyanate (HDI). Int Arch Occup Environ Health; 62: 385-389
5. Brorson T, Skarping G, Sandstrom JF et al. (1990b) Biological monitoring of isocyanates and related amines. I. Determination of 1,6-hexamethylene diamine (HDA) in hydrolysed human urine after oral administration of HDA. Int Arch Occup Environ Health; 62: 79-84.
6. Cockcroft DW, Mink JT. (1979) Isocyanate-induced asthma in an automobile spray painter. Can Med Assoc J; 121: 602-604
7. Cocker J. (2007) Biological monitoring for isocyanates. Occup Med (Lond); 57: 391-393
8. Creely KS, Hughson GW, Cocker J et al. (2006) Assessing isocyanate exposures in polyurethane industry sectors using biological and air monitoring methods. Ann Occup Hyg; 50: 609-621
9. Fent KW, Gaines LGT, Thomasen JM et al. (2009a) Quantification and statistical modeling-Part I: breathing-zone concentrations of monomeric and polymeric 1,6-hexamethylene diisocyanate. Ann Occup Hyg; ISSN 1475-3162 (electronic).
10. FentKW, Gaines LGT, Thomasen JM et al. (2009b) Quantification and statistical modeling-Part II: dermal concentrations of monomeric and polymeric 1,6-hexamethylene diisocyanate. Ann Occup Hyg; ISSN 1475-3162 (electronic).
11. Glaser JA, Foerst DL, McKee GD et al. (1981) Trace analysis for wastewaters. Environ Sci Technol; 15: 1426-1435
12. Herrick CA, Xu L, Wisnewski AV et al. (2002) A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. J Allergy Clin Immunol; 109: 873-878
13. Kaaria K, Hirvonen A, Norppa H et al. (2001) Exposure to 4,49-methylenediphenyl diisocyanate (MDI) during moulding of rigid polyurethane foam: determination of airborne MDI and urinary 4,49-methylenedianiline (MDA). Analyst; 126: 476-479
14. Keselman HJ, Algina J, Kowalchuck RK et al. (1998) A comparison of two approaches for selecting covariance structures in the analysis of repeated measurements. Commun Stat Simul Comput; 27: 591-604.
15. Lind P, Dalene M, Lindstrom Vet al. (1997a) Albumin adducts in plasma from workers exposed to toluene diisocyanate. Analyst; 122: 151-154
16. Lind P, Dalene M, Tinnerberg H et al. (1997b) Biomarkers in hydrolysed urine, plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam. Analyst; 122: 51-56
17. Liu Y, Berode M, Stowe MH et al. (2004) Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: a human inhalation study. Int J Occup Environ Health; 10: 262-271
18. Maitre A, Berode M, Perdrix A et al. (1993) Biological monitoring of occupational exposure to toluene diisocyanate. Int Arch Occup Environ Health; 65: 97-100.
19. Maitre A, Berode M, Perdrix A et al. (1996) Urinary hexane diamine as an indicator of occupational exposure to hexamethylene diisocyanate. Int Arch Occup Environ Health; 69: 65-68
20. Marand A, Karlsson D, Dalene M et al. (2004) Determination of amines as pentafluoropropionic acid anhydride derivatives in biological samples using liquid chromatography and tandem mass spectrometry. Analyst; 129: 522-528
21. OSHA. (2006) Respiratory protection - 1910.134, Regulation (Standards - 29 CFR) US Department of Labor. Available at http://www.osha.gov/. Accessed 22 September 2009.
22. Pauluhn J, Lewalter J. (2002) Analysis of markers of exposure to polymeric methylene-diphenyl diisocyanate (pMDI) in rats: a comparison of dermal and inhalation routes of exposure. Exp Toxicol Pathol; 54: 135-146
23. Pauluhn J, Mohr U. (1994) Assessment of respiratory hypersensitivity in guinea-pigs sensitized to diphenylmethane-4,49-diisocyanate (MDI) and challenged with MDI, acetylcholine or MDI-albumin conjugate. Toxicology; 92: 53-74.
24. Poovey HG, Rando RJ. (2002) Workplace TRIG and airpurifying respiratory protection. In: Lesage J, DeGraff I, Danchik RS, editors. Isocyanates: sampling, analysis, and health effects, ASTM STP 1408. West Conshohocken, PA: American Society for Testing and Materials; pp. 110-122
25. Pronk A, Preller L, Raulf-Heimsoth M et al. (2007) Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates. Am J Respir Crit Care Med; 176: 1090-1097
26. Pronk A, Yu F, Vlaanderen J et al. (2006) Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters. Occup Environ Med; 63: 624-631
27. Rattray NJ, Botham PA, Hext PMet al. (1994) Induction of respiratory hypersensitivity to diphenylmethane-4,49-diisocyanate (MDI) in guinea pigs. Influence of route of exposure. Toxicology; 88: 15-30.
28. Rosenberg C, Nikkila K, Henriks-Eckerman ML et al. (2002) Biological monitoring of aromatic diisocyanates in workers exposed to thermal degradation products of polyurethanes. J Environ Monit; 4: 711-716
29. Rosenberg C, Savolainen H. (1986) Determination of occupational exposure to toluene diisocyanate by biological monitoring. J Chromatogr; 367: 385-392
30. Sennbro CJ, Lindh CH, Mattsson C et al. (2006) Biological monitoring of exposure to 1,5-naphthalene diisocyanate and 4,49-methylenediphenyl diisocyanate. Int Arch Occup Environ Health; 79: 647-653
31. Sennbro CJ, Lindh CH, Tinnerberg H et al. (2004) Biological monitoring of exposure to toluene diisocyanate. Scand J Work Environ Health; 30: 371-378
32. Sepai O, Henschler D, Sabbioni G. (1995a) Albumin adducts, hemoglobin adducts and urinary metabolites in workers exposed to 4,49-methylenediphenyl diisocyanate. Carcinogenesis; 16: 2583-2587
33. Sepai O, Schutze D, Heinrich U et al. (1995b) Hemoglobin adducts and urine metabolites of 4,49-methylenedianiline after 4,49-methylenediphenyl diisocyanate exposure of rats. Chem Biol Interact; 97: 185-198
34. Svirbely JR, Iyengar S. (1997) The Medical Algorithms Project, Release 24.0. Chapter 2: Body dimensions and blood volumes. Blood volume from height and weight. Available at http://www.medal.org. Accessed 22 September 2009.
35. Tinnerberg H, Skarping G, Dalene M et al. (1995) Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate. Int Arch Occup Environ Health; 67: 367-374
36. USEPA. Definition and procedure for determination of the method detection limit. Title 40, Appendix B to Part 136 Revision 1.11. Available at http://ecfr.gpoaccess.gov. Accessed 22 September 2009.
37. Vandenplas O, Malo JL, Saetta M et al. (1993) Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives. Br J Ind Med; 50: 213-228
38. Wikman H, Piirila P, Rosenberg C et al. (2002) Nacetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. Pharmacogenetics; 12: 227-233
39. Wisnewski AV, Srivastava R, Herick C et al. (2000) Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care Med; 162: 2330-2336
40. Woskie SR, Sparer J, Gore RJ et al. (2004) Determinants of isocyanate exposures in auto body repair and refinishing shops. Ann Occup Hyg; 48: 393-403.
41. Zissu D, Binet S, Limasset JC. (1998) Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs. Contact Dermatitis; 39: 248-251