Optically active antifungal azoles. VI. Synthesis and antifungal activity of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 2, 1996, Pages 314-327

  Kitazaki, Tomoyuki ^a   Tamura, Norikazu ^a   Tasaka, Akihiro ^a   Matsushita, Yoshihiro ^a   Hayashi, Ryogo ^a   Okonogi, Kenji ^a   Itoh, Katsumi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

1,2,3 trisubstituted 2 butanol; Antifungal activity; Optically active antifungal azole; Stereocontrolled synthesis; Tetrazolone; Triazolone

Indexed keywords

1 [2 (2,4 DIFLUOROPHENYL) 2 OXIRANYL]ETHANOL; 4 (4 TRIFLUOROMETHOXYPHENYL) 3(2H,4H) 1,2,4 TRIAZOLONE; PYRROLE DERIVATIVE; TETRAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MYCOSIS; NONHUMAN; PHYSICAL CHEMISTRY;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CHEMISTRY, PHYSICAL; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; STEREOISOMERISM; TETRAZOLES; TRIAZOLES;

EID: 0029987005     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.314     Document Type: Article

References (31)

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