MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients

Cancer Genetics and Cytogenetics

Volumn 197, Issue 2, 2010, Pages 142-151

  Naghibalhossaini, Fakhraddin ^a   Mokarram, Pooneh ^a,b   Khalili, Islam ^a   Vasei, Mohammad ^a   Hosseini, Seyed Vahid ^b,c   Ashktorab, Hassan ^d   Rasti, Mozhgan ^a   Abdollahi, Kourosh ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d HOWARD UNIVERSITY CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; ARTICLE; BASE MISPAIRING; CANCER INCIDENCE; CANCER PATIENT; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; IRAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; SPORADIC COLORECTRAL CANCER;

AGED; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IRAN; LOGISTIC MODELS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICROSATELLITE INSTABILITY; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 77249090777     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.11.014     Document Type: Article

References (36)

1. Yazdizadeh B., Jarrahi A.M., Mortazavi H., Mohagheghi M.A., Tahmasebi S., and Nahvijo A. Time trends in the occurrence of major GI cancers in Iran. Asian Pac J Cancer Prev 6 (2005) 130-134
2. Jass J.R. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50 (2007) 113-130
3. Shen L., Toyota M., Kondo Y., Lin E., Zhang L., Guo Y., Hernandez N.S., Chen X., Ahmed S., Konishi K., Hamilton S.R., and Issa J.P. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci USA 104 (2007) 18654-18659
4. Botto L.D., and Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151 (2000) 862-877
5. Van der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet1998;62:1044-1051.
6. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., Boers G.J.H., den Heijer M., Kluijtmans L.A.J., van den Heuve L.P., and Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10 (1995) 111-113
7. Murtaugh M.A., Curtin K., Sweeney C., Wolff R.K., Holubkov R., Caan B.J., and Slattery M.L. Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Cancer Causes Control 18 (2007) 153-163
8. Yin G., Kono S., Toyomura K., Hagiwara T., Nagano J., Mizoue T., Mibu R., Tanaka M., Kakeji Y., Maehara Y., Okamura T., Ikejiri K., Futami K., Yasunami Y., Maekawa T., Takenaka K., Ichimiya H., and Imaizumi N. Methylenetetrahydrofolate reductase C677 T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Sci 95 (2004) 908-913
9. Hubner R.A., and Houlston R.S. MTHFR C677 T and colorectal cancer risk: a meta-analysis of 25 populations. Int J Cancer 120 (2007) 1027-1035
10. Kim D.H. The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer. Mutat Res 622 (2007) 14-18
11. Guerreiro C.S., Carmona B., Gonçalves S., Carolino E., Fidalgo P., Brito M., Leitão C.N., and Cravo M. Risk of colorectal cancer associated with the C677 T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. Am J Clin Nutr 88 (2008) 1413-1418
12. Kim D.H., Ahn Y.O., Lee B.H., Tsuji E., Kiyohara C., and Kono S. Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea. Cancer Lett 216 (2004) 199-205
13. Chapusot C., Martin L., Bouvier A.M., Bonithon-Kopp C., Ecarnot-Laubriet A., Rageot D., Ponnelle T., Laurent Puig P., Faivre J., and Piard F. Microsatellite instability and intratumoural heterogeneity in 100 right-sided sporadic colon carcinomas. Br J Cancer 87 (2002) 400-404
14. Shannon B., Gnanasampanthan S., Beilby J., and Iacopetta B. A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 50 (2002) 520-524
15. Hubner R.A., Lubbe S., Chandler I., and Houlston R.S. MTHFR C677 T has differential influence on risk of MSI and MSS colorectal cancer. Hum Mol Genet 16 (2007) 1072-1077
16. Clarizia A.D., Bastos-Rodrigues L., Pena H.B., Anacleto C., Rossi B., Soares F.A., Lopes A., Rocha J.C., Caballero O., Camargo A., Simpson A.J., and Pena S.D. Relationship of the methylenetetrahydrofolate reductase C677 T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer. Genet Mol Res 5 (2006) 315-322
17. Chang S.C., Lin P.C., Lin J.K., Yang S.H., Wang H.S., and Li A.F. Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers. Int J Colorectal Dis 22 (2007) 483-489
18. Eaton A.M., Sandler R., Carethers J.M., Millikan R.C., Galanko J., and Keku T.O. 5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer. Cancer Epidemiol Biomarkers Prev 14 (2005) 2023-2029
19. Toffoli G., Gafà R., Russo A., Lanza G., Dolcetti R., Sartor F., Libra M., Viel A., and Boiocchi M. Methylenetetrahydrofolate reductase 677 C → T polymorphism and risk of proximal colon cancer in north Italy. Clin Cancer Res 9 (2003) 43-48
20. Mokarram P., Naghibalhossaini F., Saberi Firoozi M., Hosseini S.V., Izadpanah A., Salahi H., Malek-Hosseini S.A., Talei A., and Mojallal M. Methylenetetrahydrofolate reductase C677 T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. World J Gastroenterol 14 (2008) 3662-3671
21. Naghibalhossaini F., Mokarram P., and Khalili I. Easy detection of 5, 10-methylenetetrahydrofolate reductase 1298A/C genotype by mutagenically separated PCR assay. Clin Chem Lab Med 46 (2008) 987-989
22. Boland C.R., Thibodeau S.N., Hamilton S.R., Sidransky D., Eshleman J.R., Burt R.W., Meltzer S.J., Rodriguez-Bigas M.A., Fodde R., Ranzani G.N., and Srivastava S. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58 (1998) 5248-5257
23. Watanabe T., Kobunai T., Toda E., Yamamoto Y., Kanazawa T., Kazama Y., Tanaka J., Tanaka T., Konishi T., Okayama Y., Sugimoto Y., Oka T., Sasaki S., Muto T., and Nagawa H. Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers. Cancer Res 66 (2006) 9804-9808
24. Ueland P.M., Hustad S., Schneede J., Refsum H., and Vollset S.E. Biological and clinical implications of the MTHFR C677 T polymorphism. Trends Pharmacol Sci 22 (2001) 195-201
25. Slattery M.L., Potter J.D., Samowitz W., Schaffer D., and Leppert M. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 8 (1999) 513-518
26. Ma J., Stampfer M.J., Giovannucci E., Artigas C., Hunter D.J., Fuchs C., Willett W.C., Selhub J., Hennekens C.H., and Rozen R. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57 (1997) 1098-1102
27. Keku T., Millikan R., Worley K., Winkel S., Eaton A., Biscocho L., Martin C., and Sandler R. 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev 11 (2002) 1611-1621
28. Heijmans B.T., Boer J.M., Suchiman H.E., Cornelisse C.J., Westendorp R.G., Kromhout D., Feskens E.J., and Slagboom P.E. A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer. Cancer Res 63 (2003) 1249-1253
29. Weisberg I., Tran P., Christensen B., Sibani S., and Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64 (1998) 169-172
30. Lipton L.R., Johnson V., Cummings C., Fisher S., Risby P., Eftekhar Sadat A.T., Cranston T., Izatt L., Sasieni P., Hodgson S.V., Thomas H.J., and Tomlinson I.P. Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic. J Clin Oncol 22 (2004) 4934-4943
31. Sugai T., Habano W., Jiao Y.F., Tsukahara M., Takeda Y., Otsuka K., and Nakamura S. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct path ways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. J Mol Diagn 8 (2006) 193-201
32. Slattery M.L., Curtin K., Anderson K., Ma K.N., Ballard L., Edwards S., Schaffer D., Potter J., Leppert M., and Samowitz W.S. Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J Natl Cancer Inst 92 (2000) 1831-1836
33. Yang P., Cunningham J.M., Halling K.C., Lesnick T.G., Burgart L.J., Wiegert E.M., Christensen E.R., Lindor N.M., Katzmann J.A., and Thibodeau S.N. Higher risk of mismatch repair-deficient colorectal cancer in alpha(1)-antitrypsin deficiency carriers and cigarette smokers. Mol Genet Metab 71 (2000) 639-645
34. Noda H., Kato Y., Yoshikawa H., Arai M., Togashi K., Nagai H., Konishi F., and Miki Y. Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer. Oncology 69 (2005) 354-362
35. Giardiello F.M., Brensinger J.D., and Petersen G.M. AGA technical review on hereditary colorectal cancer and genetic testing. Gastroenterology 121 (2001) 198-213
36. Grady W.M., Rajput A., Lutterbaugh J.D., and Markowitz S.D. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res 61 (2001) 900-902