Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients

American Journal of Clinical Nutrition

Volumn 88, Issue 5, 2008, Pages 1413-1418

  Guerreiro, Catarina Sousa ^a,b   Carmona, Bruno ^b   Gonçalves, Susana ^b   Carolino, Elisabete ^b   Fidalgo, Paulo ^c   Brito, Miguel ^b   Leitão, Carlos Nobre ^c   Cravo, Marília ^c  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO POLITÉCNICO DE LISBOA   (Portugal)

^c INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; METHIONINE SYNTHASE; METHYL GROUP;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; MTR GENE; NUTRIENT; ONCOGENE; PORTUGAL; SHMT GENE;

EID: 55849091713     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.25877     Document Type: Article

References (32)

1. Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C. 5, 10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev 2002;11:1611-21.
2. Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 2002;132(suppl):2412S-8S.
3. Kune G, Watson L. Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins B6, B12, C, E, selenium, and lycopene. Nutr Cancer 2006;56(1):11-21.
4. Crott J, Mason J. MTHFR polymorphisms and colorectal neoplasia. In: Ueland PM, and Rozen R, eds. MTHFR polymorphisms and disease. Austin, TX: Landes Bioscience, 2004;
5. Ma J, Stampfer MJ, Christensen B, et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 1999;8:825-9.
6. Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E, Ueland PM. Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS Cohort. Cancer Epidemiol Biomarkers Prev 2004;13:2175-80.
7. Luebeck EG, Moolgavkar SH, Liu AY, et al. Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions. Cancer Epidemiol Biomarkers Prev 2008;17(6):1360-7.
8. Chen J, Kyte C, Valcin M, et al. Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 2004;1:110(4):617-20.
9. Guerreiro CS, Cravo ML, Brito M, Vidal PM, Fidalgo PO, Leitão CN. The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons. Am J Clin Nutr 2007;85(6):1592-7.
10. Lopes CM. Reprodutibilidade e validação do questionário semi quantitativo de frequência alimentar. In: Alimentação e Enfarte agudo do miocárdio: Estudo de caso-controlo de base comunitária. PhD thesis. Facaldade de Medicina da Universidade do Porto Porto. 2000;78-115.
11. Arroll B, Jackson R, Beaglehole R. Validation of a three-month physical activity recall questionnaire with a seven-day food intake and physical activity diary. Epidemiology 1991;2:296-9.
12. Kim YI. Folate and carcinogenesis: evidence, mechanisms and implications. J Nutr Biochem 1999;10:66-85.
13. Fenech M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat Res 2001;475:57-67.
14. Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 2001;475:7-20.
15. Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 1999;55:578-92.
16. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Alcohol, low-methionine, low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 1995;15:87(4):265-73.
17. Su LJ, Arab L. Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Ann Epidemiol 2001;11(1):65-72.
18. Mason JB, Dickstein A, Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 2007;16(7):1325-9.
19. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
20. Friso S, Choi S, Girelli D, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 2002;99(8):5606-11.
21. Chen J, Giovannucci E, Kelsey K, et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996;56:4862-64.
22. Cravo LG, Camilo ME, Resende M, et al. DNA methylation and subclinical vitamin deficiency of folate, pyridioxal-phosphate and vitamin B12 in chronic alcoholics. Clin Nutrition 1997;16:29-33.
23. Ma J, Stampfer MJ, Giovannucci E, et al. Methyltetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997;57:1098-102.
24. Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomark Prev 1999;8:513-8.
25. Le Marchand L, Donlon T, Hankin JH, Kolonel LN, Wilkens LR, Seifreid A. B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control 2002;13:239-48.
26. Ryan BM, Molloy AM, McManus R, et al. The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumour development and significance of allelic loss in tumor progression. Int J Gastrointest Cancer 2001;30(3):105-11.
27. Sachse C, Smith G, Wilkie M, et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis 2002;23(11):1839-50.
28. Plaschke J, Schwanebeck U, Pistorius S, Saeger HD, Schackert HK. Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability. Cancer Lett 2003;10:191(2):179-85.
29. Delgado-Enciso I, Martinez-Garza SG, Rojas-Martinez A, et al. 677T mutation of MTHFR gene in adenomas and colorectal cancer in a population sample from the Northeastern Mexico. Preliminary results. Rev Gastroenterol Mex 2001;66(1):32-7.
30. Shannon B, Gnasampanthan S, Beilby J, Lacopetta BA. Polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 2002;50(4):520-4.
31. Leclerc D, Wilson A, Dumas R, et al. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci U S A 1998;95(6):3059-64.
32. Van den Donk M, Visker MH, Harryvan JL, Kok FJ, Kampman E. Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study. Cancer Lett 2007;18:250(1):146-53.