Prevention of diet-induced obesity by safflower oil: Insights at the levels of PPAR, Orexin, and Ghrelin gene expression of adipocytes in mice

Acta Biochimica et Biophysica Sinica

Volumn 42, Issue 3, 2010, Pages 202-208

  Zhang, Zhong ^a   Li, Qiang ^a   Liu, Fengchen ^a   Sun, Yuqian ^a   Zhang, Jinchao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Adiposity; Ghrelin; Orexin; PPAR; Safflower oil

Indexed keywords

GHRELIN; NEUROPEPTIDE; OREXINS; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SAFFLOWER OIL; SIGNAL PEPTIDE;

ADIPOCYTE; ANIMAL; ARTICLE; C57BL MOUSE; DIET; DIET THERAPY; GENE EXPRESSION REGULATION; MALE; METABOLISM; MOUSE; OBESITY; ORAL DRUG ADMINISTRATION;

ADIPOCYTES; ADMINISTRATION, ORAL; ANIMALS; DIET; GENE EXPRESSION REGULATION; GHRELIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; OBESITY; PPAR ALPHA; SAFFLOWER OIL;

CARTHAMUS TINCTORIUS; MUS;

EID: 77249085125     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmq010     Document Type: Article

References (29)

1. Zalilah MS, Khor GL, Mirnalini K, Norimah AK and Ang M. Dietary intake, physical activity and energy expenditure of Malaysian adolescents. Singapore Med J 2006, 47: 491-498.
2. Greenberg AS and Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr 2006, 83: 461S-465S.
3. Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R and Rosenfeld MG, et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 1998, 395: 137-143.
4. Ma XM, Yu H and Huai N. Peroxisome proliferator-activated receptorgamma is essential in the pathogenesis of gastric carcinoma. World J Gastroenterol 2009, 15: 3874-3883.
5. Ge Xu, Li Y, An WJ and Zhang WZ. Ghrelin and cell differentiation. Acta Biochim Biophys Sin 2008, 40: 841-847.
6. Zhang M, Yuan F, Liu H, Chen H, Qiu XB and Fang WY. Inhibition of proliferation and apoptosis of vascular smooth muscle cells by Ghrelin. Acta Biochim Biophys Sin 2008, 40: 769-776.
7. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N and Makino S, et al. Ghrelin is an appetite-stimulatory signal from the stomach with structural resemblance to motilin. Gastroenterology 2001, 120: 337-345.
8. Benoit SC, Tracy AL, Davis JF, Choi D and Clegg DJ. Novel functions of orexigenic hypothalamic peptides: from genes to behavior. Nutrition 2008, 24: 843-847.
9. Bray GA, Paeratakul S and Popkin BM. Dietary fat and obesity: A review of animal, clinical and epidemiological studies. Physiol Behav 2004, 83: 549-555.
10. Raynor HA, Jeffery RW, Phelan S, Hill JO and Wing RR. Amount of food group variety consumed in the diet and long-term weight loss maintenance. Obes Res 2005, 13: 883-890.
11. Wang H, Storlien L and Huang X. Effects of dietary fat types on body fatness, leptin, and Arc leptin receptor, NPY and AgRP mRNA expression. Am J Physiol Endocrinol Metab 2002, 282: E1352-E1359.
12. Ghafoorunissa, Ibrahim A, Rajkumar L and Acharya V. Dietary (n-3) long chain polyunsaturated fatty acids prevent sucrose-induced insulin resistance in rats. J Nutr 2005, 135: 2634-2638.
13. Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Schö lmerich J and Bollheimer LC. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol 2006, 36: 485-501.
14. Pellizzon M, Buison A, Ordiz F, Jr, Santa Ana L and Jen KL. Effects of dietary fatty acids and exercise on body-weight regulation and metabolism in rats. Obes Res 2002, 10: 947-955.
15. Ren B, Thelen AP, Peters JM, Gonzalez FJ and Jump DB. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Biol Chem 1997, 272: 26827-26832.
16. Nakatani T, Kim HJ, Kaburagi Y, Yasuda K and Ezaki O. A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity. J Lipid Res 2003, 44: 369-379.
17. Takeuchi H, Matsuo T, Tokuyama K, Shimomura Y and Suzuki M. Diet-induced thermogenesis is lower in rats fed a lard diet than in those fed a high oleic acid safflower oil diet, a safflower oil diet or a linseed oil diet. J Nutr 1995, 125: 920-925.
18. Schena M, Shalon D, Davis RW and Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995, 270: 467-470.
19. Czechowski T, Stitt M, Altmann T, Udvardi MK and Scheible WR. Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis. Plant Physiol 2005, 139: 5-17.
20. Xu DM, Jin Y and Xu WP. Carthamus tinctorius injection in treating stable angina pectoris. Chin J New Drugs Clin Rem 2003, 22: 13-15.
21. Dong B, Zhang SX, Liu M and Li YL. Carthamus tinctorius injection for coronary heart disease with hyperlipidemia and hyperviscosaemia in 40 patients. J Pract Trad Chin Int Med 2004, 18: 244.
22. Wilkes JJ, Bonen A and Bell RC. A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes. Am J Physiol 1998, 275: E679-E686.
23. Clore JN, Stillman JS, Li J, O'Keefe SJ and Levy JR. Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans. Am J Physiol Endocrinol Metab 2004, 287: E358-E365.
24. Zhou Y, Song GY, Gao Y, Feng ZS and Bian YZ. Effects of high sucrose, high saturated fatty acid and high unsaturated fatty acid diets on insulin resistance in aging rats. Chin J Gerontol 2006, 26: 222-224.
25. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B and Pérusse L, et al. The human obesity gene map: The 2005 update. Obesity (Silver Spring) 2006, 14: 529-644.
26. Yang W, Kelly T and He J. Genetic epidemiology of obesity. Epidemiol Rev 2007, 29: 49-61.
27. Ribet C, Montastier E, Valle C, Bezaire V, Mazzucotelli A, Mairal A and Viguerie N, et al. Peroxisome proliferator-activated receptor-a control of lipid and glucose metabolism in human white adipocytes. Endocrinology 2010, 151: 123-133.
28. Hsu SC and Huang CJ. Changes in liver PPARa mRNA expression in response to two levels of high-safflower-oil diets correlate with changes in adiposity and serum leptin in rats and mice. J Nutr Biochem 2007, 18: 86-96.
29. Hsu SC and Huang CJ. Reduced fat mass in rats fed a high oleic acid-rich safflower oil diet is associated with changes in expression of hepatic PPARa and adipose SREBP-1c-regulated genes. J Nutr 2006, 136: 1779-1785.