Inhibition of proliferation and apoptosis of vascular smooth muscle cells by ghrelin

Acta Biochimica et Biophysica Sinica

Volumn 40, Issue 9, 2008, Pages 769-776

  Zhang, Min ^a   Yuan, Fang ^a   Liu, Hua ^a   Chen, Hui ^a   Qiu, Xingbiao ^a   Fang, Weiyi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Atherosclerosis; Ghrelin; Proliferation; Vascular smooth muscle cell

Indexed keywords

CYCLINE; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; FORMAZAN; GHRELIN; LIPOCORTIN 5; MTT FORMAZAN; TETRAZOLIUM;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CULTURE MEDIUM; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; RAT; SMOOTH MUSCLE FIBER; THORACIC AORTA; ULTRASTRUCTURE; VASCULAR SMOOTH MUSCLE; WISTAR RAT;

ANIMALS; ANNEXIN A5; AORTA, THORACIC; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; FORMAZANS; GHRELIN; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; TETRAZOLIUM SALTS;

RATTUS;

EID: 54749146658     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2008.00457.x     Document Type: Article

References (21)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402 : 656 660.
2. Katugampola SD, Maguire JJ, Kuc RE, Wiley KE, Davenport AP. Discovery of recently adopted orphan receptors for apelin, urotensin II, and ghrelin identified using novel radioligands and functional role in the human cardiovascular system. Can J Physiol Pharmacol 2002, 80 : 369 374.
3. Chang L, Ren Y, Liu X, Li WG, Yang J, Geng B, Weintraub NL et al. Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart. J Cardiovasc Pharmacol 2004, 43 : 165 170.
4. Shimizu Y, Nagaya N, Teranishi Y, Imazu M, Yamamoto H, Shokawa T, Kangawa K et al. Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats. Biochem Biophys Res Commun 2003, 310 : 830 835.
5. Li GZ, Jiang W, Zhao J, Pan CS, Cao J, Tang CS, Chang L. Ghrelin blunted vascular calcification in vivo and in vitro in rats. Regul Pept 2005, 129 : 167 176.
6. Avallone R, Demers A, Rodrigue-Way A, Bujold K, Harb D, Anghel S, Wahli W et al. A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor γ-dependent pathway. Mol Endocrinol 2006, 20 : 3165 3178.
7. Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML et al. Ghrelin inhibits proinflammatory responses and nuclear factor-κB activation in human endothelial cells. Circulation 2004, 109 : 2221 2226.
8. Zhang M, Yuan F, Chen H, Qiu X, Fang W. Effect of exogenous ghrelin on cell differentiation antigen 40 expression in endothelial cells. Acta Biochim Biophys Sin 2007, 39 : 974 981.
9. Lavezzi AM, Ottaviani G, Matturri L. Biology of the smooth muscle cells in human atherosclerosis. APMIS 2005, 113 : 112 121.
10. Deng DX, Spin JM, Tsalenko A, Vailaya A, Ben-Dor A, Yakhini Z, Tsao P et al. Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli. Arterioscler Thromb Vasc Biol 2006, 26 : 1058 1065.
11. Bochaton-Piallat ML, Gabbiani G. Modulation of smooth muscle cell proliferation and migration: role of smooth muscle cell heterogeneity. Handb Exp Pharmacol 2005, 170 : 645 663.
12. Niemann-Jonsson A, Ares MP, Yan ZQ, Bu DX, Fredrikson GN, Branen L, Porn-Ares I et al. Increased rate of apoptosis in intimal arterial smooth muscle cells through endogenous activation of TNF receptors. Arterioscler Thromb Vasc Biol 2001, 21 : 1909 1914.
13. Yan Z, Hansson GK. Overexpression of inducible nitric oxide syn-thase by neointimal smooth muscle cells. Circ Res 1998, 82 : 21 29.
14. Zhang YK, Shen GF, Ru BG. Survival of human metallothionein-2 transplastomic Chlamydomonas reinhardtii to ultraviolet B exposure. Acta Biochim Biophys Sin 2006, 38 : 187 193.
15. + T cell responses in mice infected with Schisto-soma japonicum. Acta Biochim Biophys Sin 2006, 38 : 327 334.
16. Pellicciari C, Danova M, Giordano M, Fuhrman Conti AM, Mazzini G, Wang E, Ronchetti E et al. Expression of cell cycle related proteins - proliferating cell nuclear antigen (PCNA) and statin - during adaptation and de-adaptation of EUE cells to a hypertonic medium. Cell Prolif 1991, 24 : 469 479.
17. Young Cruz CR, Smith RG. The growth hormone secretagogue receptor. Vitam Horm 2008, 77 : 47 88.
18. Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000, 279 : 909 913.
19. Nishi Y, Hiejima H, Mifune H, Sato T, Kangawa K, Kojima M. Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelin in murine stomach. Endocrinology 2005, 146 : 2709 2715.
20. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI3K-AKT. J Cell Biol 2002, 159 : 1029 1037.
21. Muccioli G, Pons N, Ghe C, Catapano F, Granata R, Ghigo E. Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type la growth hormone secretagogue receptor. Eur J Pharmacol 2004, 498 : 27 35.