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Volumn 59, Issue 2, 2010, Pages 149-151

Interleukin-6: A therapeutic Jekyll and Hyde in gastrointestinal and hepatic diseases

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLOID A PROTEIN; C REACTIVE PROTEIN; ENDOTOXIN; FIBRINOGEN; GLYCOPROTEIN GP 130; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; RECEPTOR ANTIBODY; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

EID: 77149147422     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2008.173534     Document Type: Note
Times cited : (11)

References (16)
  • 1
    • 84925549112 scopus 로고    scopus 로고
    • The paradigm of IL-6: From basic science to medicine
    • Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res 2002;4:S233-42.
    • (2002) Arthritis Res , vol.4
    • Naka, T.1    Nishimoto, N.2    Kishimoto, T.3
  • 2
    • 33748121115 scopus 로고    scopus 로고
    • Interleukin-6 and chronic inflammation
    • Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther 2006;8:S3.
    • (2006) Arthritis Res Ther , vol.8
    • Gabay, C.1
  • 3
    • 44949130806 scopus 로고    scopus 로고
    • Signaling molecules: The pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
    • Atreya R, Neurath MF. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr Drug Targets 2008;9:369-74.
    • (2008) Curr Drug Targets , vol.9 , pp. 369-374
    • Atreya, R.1    Neurath, M.F.2
  • 4
    • 51049089284 scopus 로고    scopus 로고
    • The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis
    • Weigmann B, Lehr HA, Yancopoulos G, et al. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med 2008;205:2099-110.
    • (2008) J Exp Med , vol.205 , pp. 2099-2110
    • Weigmann, B.1    Lehr, H.A.2    Yancopoulos, G.3
  • 5
    • 46749154270 scopus 로고    scopus 로고
    • The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    • Mudter J, Amoussina L, Schenk M, et al. The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest 2008;118:2415-26.
    • (2008) J Clin Invest , vol.118 , pp. 2415-2426
    • Mudter, J.1    Amoussina, L.2    Schenk, M.3
  • 6
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000;6:583-8.
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3
  • 7
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004;126:989-96.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 8
    • 77149154988 scopus 로고    scopus 로고
    • IL-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice
    • Jin X, Zimmers T, Zhang Z, et al. IL-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut 2010;59:186-96.
    • (2010) Gut , Issue.59 , pp. 186-196
    • Jin, X.1    Zimmers, T.2    Zhang, Z.3
  • 9
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, Fantini MC, Schramm C, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004;21:491-501.
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3
  • 10
    • 32944463507 scopus 로고    scopus 로고
    • Cytokines, STATs and liver disease
    • Gao B. Cytokines, STATs and liver disease. Cell Mol Immunol 2005;2:92-100.
    • (2005) Cell Mol Immunol , vol.2 , pp. 92-100
    • Gao, B.1
  • 11
    • 16844387413 scopus 로고    scopus 로고
    • The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury
    • Klein C, Wustefeld T, Assmus U, et al. The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J Clin Invest 2005;115:860-9.
    • (2005) J Clin Invest , vol.115 , pp. 860-869
    • Klein, C.1    Wustefeld, T.2    Assmus, U.3
  • 12
    • 0242348793 scopus 로고    scopus 로고
    • Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms
    • Haga S, Terui K, Zhang HQ, et al. Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest 2003;112:989-98.
    • (2003) J Clin Invest , vol.112 , pp. 989-998
    • Haga, S.1    Terui, K.2    Zhang, H.Q.3
  • 13
    • 41349098793 scopus 로고    scopus 로고
    • Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury
    • Horiguchi N, Wang L, Mukhopadhyay P, et al. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 2008;134:1148-58.
    • (2008) Gastroenterology , vol.134 , pp. 1148-1158
    • Horiguchi, N.1    Wang, L.2    Mukhopadhyay, P.3
  • 14
    • 4644237206 scopus 로고    scopus 로고
    • Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
    • Hong F, Radaeva S, Pan HN, et al. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology 2004;40:933-41.
    • (2004) Hepatology , vol.40 , pp. 933-941
    • Hong, F.1    Radaeva, S.2    Pan, H.N.3
  • 15
    • 0038575467 scopus 로고    scopus 로고
    • In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats
    • Sun Z, Klein AS, Radaeva S, et al. In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology 2003;125:202-15.
    • (2003) Gastroenterology , vol.125 , pp. 202-215
    • Sun, Z.1    Klein, A.S.2    Radaeva, S.3
  • 16
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121-4.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.