Possible adverse effect of high δ-alpha-tocopherol intake on hepatic iron overload: Enhanced production of vitamin C and the genotoxin, 8-hydroxy-2′- deoxyguanosine

Toxicology Mechanisms and Methods

Volumn 20, Issue 2, 2010, Pages 96-104

  Asare, George A ^a   Ntombini, Bicky ^b   Kew, Michael C ^a   Kahler Venter, Christina P ^b   Nortey, Ezekiel N ^c  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY   (South Africa)

^c UNIVERSITY OF GHANA   (Ghana)

Author keywords

Tocopherol; 8 hydroxy 2 deoxyguanosine; Antioxidants; Iron overload

Indexed keywords

8 HYDROXY 2A DEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; DELTA ALPHA TOCOPHEROL; FERROCENE; GLUTATHIONE; OXYGEN RADICAL; TOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET; ENZYME BLOOD LEVEL; HEMOCHROMATOSIS; HUMAN; IRON BLOOD LEVEL; IRON OVERLOAD; LIPID PEROXIDATION; LIVER; LIVER CELL; LIVER INJURY; MACROPHAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CATALASE; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; FERROUS COMPOUNDS; GLUTATHIONE; IRON; IRON OVERLOAD; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; TIME FACTORS; UP-REGULATION; VITAMINS;

RATTUS;

EID: 77149140835     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376510903572888     Document Type: Article

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