Use of 8-Substituted-FAD Analogues to Investigate the Hydroxylation Mechanism of the Flavoprotein 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase

Biochemistry

Volumn 43, Issue 13, 2004, Pages 3933-3943

  Chaiyen, Pimchai ^a   Sucharitakul, Jeerus ^a   Svasti, Jisnuson ^a   Entsch, Barrie ^b   Massey, Vincent ^b   Ballou, David P ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CATALYSIS; ENZYME KINETICS; HYDROXYLATION; OXYGENATORS; PROTEINS; REDOX REACTIONS; SUBSTITUTION REACTIONS; THERMODYNAMIC PROPERTIES;

FLAVOPROTEINS; MARCUS ELECTRON TRANSFER THEORY; OXYGENATION REACTIONS;

BIOCHEMISTRY;

2 METHYL 3 HYDROXYPYRIDINE 5 CARBOXYLIC ACID; 2 METHYL 3 HYDROXYPYRIDINE 5 CARBOXYLIC ACID OXYGENASE; 4 HYDROXYBENZOATE HYDROXYLASE; 5 HYDROXYNICOTINATE; ALPHA (N ACETYLAMINOMETHYLENE)SUCCINIC ACID; FLAVINE ADENINE NUCLEOTIDE; FLAVOPROTEIN; NICOTINIC ACID; OXYGENASE; PHENOL DERIVATIVE; PYRIDINE DERIVATIVE; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; DISSOCIATION CONSTANT; ELECTRON TRANSPORT; ENZYME KINETICS; ENZYME RECONSTITUTION; HYDROXYLATION; LIGAND BINDING; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXYGEN TRANSPORT; OXYGENATION; PKA; PRIORITY JOURNAL; REDUCTION; THERMODYNAMICS;

APOENZYMES; BINDING SITES; CATALYSIS; FLAVIN-ADENINE DINUCLEOTIDE; FLAVOPROTEINS; HYDROXYLATION; KINETICS; MIXED FUNCTION OXYGENASES; NICOTINIC ACIDS; OXIDATION-REDUCTION; OXYGEN; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 1842591347     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035734d     Document Type: Article

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