Lymphocyte subset recovery following allogeneic bone marrow transplantation: CD4+-cell count and transplant-related mortality

Bone Marrow Transplantation

Volumn 41, Issue 1, 2008, Pages 19-21

  Talmadge, J E ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE LYMPHOCYTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC MYELOID LEUKEMIA; COHORT ANALYSIS; CORRELATION ANALYSIS; HUMAN; INFECTION RISK; LYMPHOCYTE COUNT; MORTALITY; MULTIVARIATE ANALYSIS; NATURAL KILLER CELL; NOTE; OPPORTUNISTIC INFECTION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; RISK REDUCTION; T LYMPHOCYTE SUBPOPULATION;

CD4 LYMPHOCYTE COUNT; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; TRANSPLANTATION, HOMOLOGOUS;

EID: 38349019425     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705871     Document Type: Note

References (19)

1. Mills KC, Gross TG, Varney ML, Heimann DG, Reed EC, Kessinger A et al Immunologic phenotype and function in human bong marww, blood stem cells and umbilical cord blood. Bone Marrow Transplant 1996; 18 53-61.
2. Pavletic ZS, Bishop MR, Tarantolo SR, Martin-Algarra S, Bierman PJ, Vose JM et al. Hematopoietic recovery after allogeneic blood stem-cell transplantation compared with bone marrow transplantation in patients withl hematologic malignancies. J Chn Oncol 1997; 15 1608-1616.
3. Tayebi H, Tiberghien P, Ferrand C, Lienard A, Duperrier A, Cahn JY et al. Allogeneic peripheral bloodw stem cell transplantation results in less alteration of early T cell compartment homeostasis than bone, marrow-transplantation, Bone Marrow Transplant 2001; 27: 167-175.
4. Aversa F, Tabiho A, Velardi A, Cunningham I, Terenzi A, Falzetti F et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors. with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186-1193.
5. Chakrabarti S, MacDonald D, Hale G, Holder, K, Turner V, Czarnecka H et al. T-cell depletion with Campath-1H 'in the bag' for matched related allogeneic peripheral, blood stem cell transplantatiqp is associated with reduced graft-versus-host disease, rapid immune constitution and improved survival. Br J Haematol 2003; 121: 109-118.
6. Menendez P, Perez-Simon JA, Mateos MV, Caballero MD, Gonzalez M, San-Miguel F et al. Influence of the different CD34+ and CD34 cell subsets infused on clinical outcome after non-myeloablative allogeneic peripheral blood transplantation from human leucocyte antigen-identical sibling donors: Br J Haematol 2002; 119: 135-143.
7. Storek J, Dawson MA, Maloney DG. Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation. Biol Blood Marrow Transplant 2003; 9: 781-784.
8. Kim DH, Sohn SK, Won DI, Lee NY, Suh JS, Lee KB. Rapid helper T-cell recovery above 200 × 10 6/1 at 3 months correlatesr to successful transplant outcomes after allogeneic stem cell transplantation. Bone Marrow Transplant 2006; 37: 1119-1128.
9. Koehl U, Bochennek K, Zimmermann SY, Lehrnbecher T, Sorensen J, Esser R et al. Immune recovery in children undergoing allogeneic Aterl cell transplantation: Absolute CD8 + CD3 + count reconstitution is associated with survival. Bone Marrow Transplant 2007; 39: 269-278.
10. Novitzky N, Davison GM, Hale G, Waldmann H. Immune reconstruction at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome. Transplantation 2002; 74 1551-1559.
11. Chakrabarti S, Brown J, Guttridge M, Pamphilon DH, Lankester A, Marks DI. Early lymphocyte recovery is an important determinant of outcome following allogeneic transplantation with CD34+ selected graft and limited T-cell addback. Bone Marrow Transplant 2003; 32: 23-30.
12. Savani BN, Mielke S, Adams S, Uribe M, Rezvani K, Yong AS, et al. Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in, patients with myeloid leukemias but not with acute lymphoblastic leukemia. Leukemia 2007 (E-pub ahead of print).
13. Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R. Infectious morbidity in long-term survivors of allogeneic marrow transplantion is associated with low CD4 T cell counts. Am J Hentatol 1997; 54 131-138.
14. + cell count and transplant related mortality. Bone Marrow Transplant 2008; 41: 55-62.
15. Savani BN, Rezvani K, Mielke S, Montero A, Kurlander R, Carter CS et al. Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia. Blood 2006; 107: 1688-1095.
16. Storek J, Witherspoon RP, Storb R. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplant 1995; 16: 413-425.
17. Atkinson K, Hansen JA, Storb R, Goehle S, Goldstein G, Thomas ED. T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets. Blood 1982; 59: 1292-1298.
18. Heining C, Spyridonidis A, Bernhardt E, Schulte-Monting J, Behringer D, Grullich C et al. Lymphocyte reconstitution following allogeneic: hematopoietid stem cell transplantation: A retrospective study. including 148 patients. Bone Marrow Transplant 2007; 39: 613-622.
19. Talmadge JE. Pathways mediating the expansion and immunosuppressive activity of MDSCs, and their relevance to cancer therapy. Clin Cancer Res 2007 (E-pub ahead of print).