SCOPUS 정보 검색 플랫폼

Volumn 28, Issue 10, 2009, Pages 1130-1147

A three dimensional pharmacophore modeling for KDR and tie-2 receptor tyrosine kinase inhibitors and virtual screening for new multikinase inhibitors

(3) Kansal, Neha a Silakari, Om a Ravikumar, Muttineni b

a PUNJABI UNIVERSITY (India)

b GVK BIOSCIENCES PVT LTD (India)

Author keywords

CATALYST; Database screening; Drug design; KDR; Molecular modeling; Pharmacophore; Receptor tyrosine kinase; Tie 2

Indexed keywords

PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TIE RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CATALYSIS; CATALYST; CONTROLLED STUDY; CORRELATION COEFFICIENT; COST BENEFIT ANALYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; PHARMACOPHORE; PRIORITY JOURNAL; RANDOMIZATION; VALIDATION STUDY;

EID: 77049117046 PISSN: 1611020X EISSN: 16110218 Source Type: Journal
DOI: 10.1002/qsar.200860200 Document Type: Article

Times cited : (3)

References (37)

1
- 0025343230
- A. Ullrich, J. Schlessinger, Cell 1990, 61, 203-212.
- (1990) Cell , vol.61 , pp. 203-212
- Ullrich, A.¹ Schlessinger, J.²

2
- 0033786922
- S. R. Hubbard, J. H. Till, Ann. Rev. Biochem. 2000, 69, 373-398.
- (2000) Ann. Rev. Biochem , vol.69 , pp. 373-398
- Hubbard, S.R.¹ Till, J.H.²

3
- 0034648765
- P. Carmeliet, R. K. Jain, Nature 2000, 407, 249-257.
- (2000) Nature , vol.407 , pp. 249-257
- Carmeliet, P.¹ Jain, R.K.²

4
- 84975525035
- J. Folkman, N. Engl. J. Med. 1995, 333, 1757-1763.
- (1995) N. Engl. J. Med , vol.333 , pp. 1757-1763
- Folkman, J.¹

5
- 0028929803
- J. Folkman, Nat. Med. 1995, 1, 27-31.
- (1995) Nat. Med , vol.1 , pp. 27-31
- Folkman, J.¹

6
- 0031969264
- B. R. Zetter, Ann. Rev. Med. 1998, 49, 407-424.
- (1998) Ann. Rev. Med , vol.49 , pp. 407-424
- Zetter, B.R.¹

7
- 17044375054
- J. T. Kuethe, A. Wong, C. X. Qu, J. Smitrovich, I.W. Davies, D. L. Hughes, J. Org. Chem. 2005, 70, 2555-2567.
- (2005) J. Org. Chem , vol.70 , pp. 2555-2567
- Kuethe, J.T.¹ Wong, A.² Qu, C.X.³ Smitrovich, J.⁴ Davies, I.W.⁵ Hughes, D.L.⁶

8
- 0034648793
- G. D. Yancopoulos, S. Davis, N. W. Gale, J. S. Rudge, Wiegand, S. J. Holash, J. Nature 2000, 407, 242-248.
- (2000) Nature , vol.407 , pp. 242-248
- Yancopoulos, G.D.¹ Davis, S.² Gale, N.W.³ Rudge, J.S.⁴ Wiegand, S.J.⁵ Holash, J.⁶

9
- 0036269854
- M. T.; Bilodeau, M. E.; Fraley, G. D. Hartman, Expert Opin. Invest. Drugs 2002, 11, 737-745.
- (2002) Expert Opin. Invest. Drugs , vol.11 , pp. 737-745
- T, M.¹ Bilodeau, M.E.² Fraley³ Hartman, G.D.⁴

10
- 0029006696
- F. Shalaby, J. Rossant, T. P. Yamaguchi, M. Gertsenstein, X. F. Wu, M. L. Breitman, A. C. Schuh, Nature 1995, 376, 62-66.
- (1995) Nature , vol.376 , pp. 62-66
- Shalaby, F.¹ Rossant, J.² Yamaguchi, T.P.³ Gertsenstein, M.⁴ Wu, X.F.⁵ Breitman, M.L.⁶ Schuh, A.C.⁷

11
- 0342657703
- I. Kim, H. G. Kim, S. O. Moon, S.W. Chae, J.-N. So, K. N. Koh, B. C. Ahn, G. Y. Koh, Circ. Res. 2000, 86, 952-959.
- (2000) Circ. Res , vol.86 , pp. 952-959
- Kim, I.¹ Kim, H.G.² Moon, S.O.³ Chae, S.W.⁴ So, J.-N.⁵ Koh, K.N.⁶ Ahn, B.C.⁷ Koh, G.Y.⁸

12
- 33947721745
- S. Huang, R. Li, P. J. Connolly, S. Emanuel, A. Fuentes-Pesquera, M. Adams, R. H. Gruninger, J. Seraj, S. A. Middleton, J. M. Davis, D. F. C. Moffat, Biorg. Med. Chem. Lett. 2007, 17, 2179-2183.
- (2007) Biorg. Med. Chem. Lett , vol.17 , pp. 2179-2183
- Huang, S.¹ Li, R.² Connolly, P.J.³ Emanuel, S.⁴ Fuentes-Pesquera, A.⁵ Adams, M.⁶ Gruninger, R.H.⁷ Seraj, J.⁸ Middleton, S.A.⁹ Davis, J.M.¹⁰ Moffat, D.F.C.¹¹

13
- 33847159338
- Y. Miyazaki, J. Tang, Y. Maeda, M. Nakano, L. Wang, R. T. Nolte, H. Sato, M. Sugai, Y. Okamoto, A. T. Truesdale, D. F. Hassler, E. N. Nartey, D. R. Patrick, M. L. Ho, K. Ozawa, Biorg. Med. Chem. Lett. 2007, 17, 1773-1778.
- (2007) Biorg. Med. Chem. Lett , vol.17 , pp. 1773-1778
- Miyazaki, Y.¹ Tang, J.² Maeda, Y.³ Nakano, M.⁴ Wang, L.⁵ Nolte, R.T.⁶ Sato, H.⁷ Sugai, M.⁸ Okamoto, Y.⁹ Truesdale, A.T.¹⁰ Hassler, D.F.¹¹ Nartey, E.N.¹² Patrick, D.R.¹³ Ho, M.L.¹⁴ Ozawa, K.¹⁵

14
- 20244380969
- Y. Miyazaki, S. Matsunaga, J. Tang, Y. Maeda, M. Nakano, R. J. Philippe, M. Shibahara, W. Liu, H. Sato, L. Wang, R. T. Nolte, Biorg. Med. Chem. Lett. 2005, 15, 2203-2207.
- (2005) Biorg. Med. Chem. Lett , vol.15 , pp. 2203-2207
- Miyazaki, Y.¹ Matsunaga, S.² Tang, J.³ Maeda, Y.⁴ Nakano, M.⁵ Philippe, R.J.⁶ Shibahara, M.⁷ Liu, W.⁸ Sato, H.⁹ Wang, L.¹⁰ Nolte, R.T.¹¹

15
- 34147137124
- Y. Dai, K. Ji, Z. Hartandi, A. A. Ahmed, D. H. Albert, J. L. Bauch, J. J. Bouska, P. F. Bousquet, G. A. Cunha, K. B. Glaser, C. M. Harris, D. Hickman, J. Guo, J. Li, P. A. Marcotte, K. C. Marsh, M. D. Moskey, R. L. Martin, A. M. Olson, D. J. Osterling, L. J. Pease, N. B. Soni, K. D. Stewart, V. S. Stoll, P. Tapang, D. R. Reuter, S. K. Davidsen, M. R. Michaelides, J. Med. Chem. 2007, 50, 1584-1597.
- (2007) J. Med. Chem , vol.50 , pp. 1584-1597
- Dai, Y.¹ Ji, K.² Hartandi, Z.³ Ahmed, A.A.⁴ Albert, D.H.⁵ Bauch, J.L.⁶ Bouska, J.J.⁷ Bousquet, P.F.⁸ Cunha, G.A.⁹ Glaser, K.B.¹⁰ Harris, C.M.¹¹ Hickman, D.¹² Guo, J.¹³ Li, J.¹⁴ Marcotte, P.A.¹⁵ Marsh, K.C.¹⁶ Moskey, M.D.¹⁷ Martin, R.L.¹⁸ Olson, A.M.¹⁹ Osterling, D.J.²⁰ more..

16
- 33847413104
- V. J. Cee, B. K. Albrecht, S. G. Meyer, P. Hughes, S. Bellon, J. Bready, S. Caenepeel, S. C. Chaffee, A. Coxon, M. Emery, J. Fretland, P. Gallant, Y. Gu, B. L. Hodous, D. Hoffman, R. E. Johnson, R. Kendall, J. L. Kim, A. M. Long, D. McGowan, M. Morrison, P. R. Olivieri, V. F. Patel, A. Polverino, D. Powers, P. Rose, L. Wang, H. Zhao, J. Med. Chem. 2007, 50, 627-640.
- (2007) J. Med. Chem , vol.50 , pp. 627-640
- Cee, V.J.¹ Albrecht, B.K.² Meyer, S.G.³ Hughes, P.⁴ Bellon, S.⁵ Bready, J.⁶ Caenepeel, S.⁷ Chaffee, S.C.⁸ Coxon, A.⁹ Emery, M.¹⁰ Fretland, J.¹¹ Gallant, P.¹² Gu, Y.¹³ Hodous, B.L.¹⁴ Hoffman, D.¹⁵ Johnson, R.E.¹⁶ Kendall, R.¹⁷ Kim, J.L.¹⁸ Long, A.M.¹⁹ McGowan, D.²⁰ more..

17
- 33751032849
- S. Huang, R. Li, P. J. Connolly, G. Xu, M. D. Gaul, S. L. Emanuel, K. R. Lamontagne, L. M. Greenberger, Biorg. Med. Chem. Lett. 2006, 16, 6063-6066.
- (2006) Biorg. Med. Chem. Lett , vol.16 , pp. 6063-6066
- Huang, S.¹ Li, R.² Connolly, P.J.³ Xu, G.⁴ Gaul, M.D.⁵ Emanuel, S.L.⁶ Lamontagne, K.R.⁷ Greenberger, L.M.⁸

18
- 37549019605
- Y. Dai, K. Hartandi, N. B. Soni, L. J. Pease, D. R. Reuter, A. M. Olson, D. J. Osterling, S. Z. Doktor, D. H. Albert, J. J. Bouska, K. B. Glaser, P. A. Marcotte, K. D. Stewart, S. K. Davidsen, M. R. Michaelides, Biorg. Med. Chem. Lett. 2008, 18, 386-390.
- (2008) Biorg. Med. Chem. Lett , vol.18 , pp. 386-390
- Dai, Y.¹ Hartandi, K.² Soni, N.B.³ Pease, L.J.⁴ Reuter, D.R.⁵ Olson, A.M.⁶ Osterling, D.J.⁷ Doktor, S.Z.⁸ Albert, D.H.⁹ Bouska, J.J.¹⁰ Glaser, K.B.¹¹ Marcotte, P.A.¹² Stewart, K.D.¹³ Davidsen, S.K.¹⁴ Michaelides, M.R.¹⁵

19
- 34249698235
- T. V. Hughes, S. L. Emanuel, A. K. Beck, S. K. Wetter, P. J. Connolly, P. Karnachi, M. Reuman, J. Seraj, A. R. Fuentes-Pesquera, R. H. Gruninger, S. A. Middleton, R. Lin, J. M. Davis, D. F. C. Moffat, Biorg. Med. Chem. Lett. 2007, 17, 3266-3270.
- (2007) Biorg. Med. Chem. Lett , vol.17 , pp. 3266-3270
- Hughes, T.V.¹ Emanuel, S.L.² Beck, A.K.³ Wetter, S.K.⁴ Connolly, P.J.⁵ Karnachi, P.⁶ Reuman, M.⁷ Seraj, J.⁸ Fuentes-Pesquera, A.R.⁹ Gruninger, R.H.¹⁰ Middleton, S.A.¹¹ Lin, R.¹² Davis, J.M.¹³ Moffat, D.F.C.¹⁴

20
- 33748313108
- N. C. Becknell, A. L. Zulli, T. S. Angeles, S. Yang, M. S. Albom, L. D. Aimone, C. Robinson, H. Chang, R. L. Hudkins, Biorg. Med. Chem. Lett. 2006, 16, 5368-5372.
- (2006) Biorg. Med. Chem. Lett , vol.16 , pp. 5368-5372
- Becknell, N.C.¹ Zulli, A.L.² Angeles, T.S.³ Yang, S.⁴ Albom, M.S.⁵ Aimone, L.D.⁶ Robinson, C.⁷ Chang, H.⁸ Hudkins, R.L.⁹

21
- 33847377928
- B. L. Hodous, S. D. Geuns-Meyer, P. E. Hughes, B. K. Albrecht, S. Bellon, J. Bready, S. Caenepeel, V. J. Cee, S. C. Chaffee, A. Coxon, M. Emery, J. Fretland, P. Gallant, Y. Gu, D. Hoffman, R. E. Johnson, R. Kendall, J. L. Kim, A. M. Long, M. Morrison, P. R. Olivieri, V. F. Patel, A. Polverino, P. Rose, P. Tempest, L. Wang, D. A. Whittington, H. Zhao, J. Med. Chem. 2007, 50, 611-626.
- (2007) J. Med. Chem , vol.50 , pp. 611-626
- Hodous, B.L.¹ Geuns-Meyer, S.D.² Hughes, P.E.³ Albrecht, B.K.⁴ Bellon, S.⁵ Bready, J.⁶ Caenepeel, S.⁷ Cee, V.J.⁸ Chaffee, S.C.⁹ Coxon, A.¹⁰ Emery, M.¹¹ Fretland, J.¹² Gallant, P.¹³ Gu, Y.¹⁴ Hoffman, D.¹⁵ Johnson, R.E.¹⁶ Kendall, R.¹⁷ Kim, J.L.¹⁸ Long, A.M.¹⁹ Morrison, M.²⁰ more..

22
- 33846902851
- H. R. Heyman, R. R. Frey, P. F. Bousquet, G. A. Cunha, M. D. Moskey, A. A. Ahmed, N. B. Soni, P. A. Marcotte, L. J. Pease, K. B. Glaser, M. Yates, J. J. Bouska, D. H. Albert, C. L. Black-Schaefer, P. J. Dandliker, K. D. Stewart, P. Rafferty, S. K. Davidsen, M. R. Michaelides, M. L. Curtin, Biorg. Med. Chem. Lett. 2007, 17, 1246-1249.
- (2007) Biorg. Med. Chem. Lett , vol.17 , pp. 1246-1249
- Heyman, H.R.¹ Frey, R.R.² Bousquet, P.F.³ Cunha, G.A.⁴ Moskey, M.D.⁵ Ahmed, A.A.⁶ Soni, N.B.⁷ Marcotte, P.A.⁸ Pease, L.J.⁹ Glaser, K.B.¹⁰ Yates, M.¹¹ Bouska, J.J.¹² Albert, D.H.¹³ Black-Schaefer, C.L.¹⁴ Dandliker, P.J.¹⁵ Stewart, K.D.¹⁶ Rafferty, P.¹⁷ Davidsen, S.K.¹⁸ Michaelides, M.R.¹⁹ Curtin, M.L.²⁰ more..

23
- 24944543833
- Y. Dai, Y. Guo, R. R. Frey, Z. Ji, M. L. Curtin, A. A. Ahmed, D. H. Albert, L. Arnold, S. S. Arries, T. Barlozzari, J. L. Bauch, J. L. Bouska, P. F. Bousquet, G. A. Cunha, K. B. Glaser, J. Guo, J. Li, P. A. Marcotte, K. C. Marsh, M. D. Moskey, L. J. Pease, K. D. Stewart, V. S. Stoll, P. Tapang, N. Wishart, S. K. Davidsen, M. R. Michaelides, J. Med. Chem. 2005, 48, 6066-6083.
- (2005) J. Med. Chem , vol.48 , pp. 6066-6083
- Dai, Y.¹ Guo, Y.² Frey, R.R.³ Ji, Z.⁴ Curtin, M.L.⁵ Ahmed, A.A.⁶ Albert, D.H.⁷ Arnold, L.⁸ Arries, S.S.⁹ Barlozzari, T.¹⁰ Bauch, J.L.¹¹ Bouska, J.L.¹² Bousquet, P.F.¹³ Cunha, G.A.¹⁴ Glaser, K.B.¹⁵ Guo, J.¹⁶ Li, J.¹⁷ Marcotte, P.A.¹⁸ Marsh, K.C.¹⁹ Moskey, M.D.²⁰ more..

24
- 34247370247
- B. L. Hodous, S. D. Geuns-Meyer, P. E. Hughes, B. K. Albrecht, S. Bellon, S. Caenepeel, V. J. Cee, S. C. Chaffee, M. Emery, J. Fretland, P. Gallant, Y. Gu, R. E. Johnson, J. L. Kim, A. M. Long, M. Morrison, P. R. Olivieri, V. F. Patel, A. Polverino, P. Rose, L. Wang, H. Zhao, Biorg. Med. Chem. Lett. 2007, 17, 2886-2889.
- (2007) Biorg. Med. Chem. Lett , vol.17 , pp. 2886-2889
- Hodous, B.L.¹ Geuns-Meyer, S.D.² Hughes, P.E.³ Albrecht, B.K.⁴ Bellon, S.⁵ Caenepeel, S.⁶ Cee, V.J.⁷ Chaffee, S.C.⁸ Emery, M.⁹ Fretland, J.¹⁰ Gallant, P.¹¹ Gu, Y.¹² Johnson, R.E.¹³ Kim, J.L.¹⁴ Long, A.M.¹⁵ Morrison, M.¹⁶ Olivieri, P.R.¹⁷ Patel, V.F.¹⁸ Polverino, A.¹⁹ Rose, P.²⁰ Wang, L.²¹ Zhao, H.²² more..

25
- 0031821433
- A. J. Kolb, P. V. Kaplita, D. J. Hayes, Y.-W. Park, C. Pernell, J. S. Major, G. Mathis, Drug Disco. Tod. 1998, 3, 333-342.
- (1998) Drug Disco. Tod , vol.3 , pp. 333-342
- Kolb, A.J.¹ Kaplita, P.V.² Hayes, D.J.³ Park, Y.-W.⁴ Pernell, C.⁵ Major, J.S.⁶ Mathis, G.⁷

26
- 77049104012
- CATALYST 4.10, Accelrys Inc., San Diego, CA, 2005, http://www.accelrys.com/
- CATALYST 4.10, Accelrys Inc., San Diego, CA, 2005, http://www.accelrys.com/

27
- 84986522856
- A. Smellie, S. Teig, P. Towbin, J. Comput. Chem. 1995, 16, 171-187.
- (1995) J. Comput. Chem , vol.16 , pp. 171-187
- Smellie, A.¹ Teig, S.² Towbin, P.³

28
- 84986512474
- B. R. Brooks, R. E. Brucolleri, B. D. Olafson, D. J. States, S. Swaminathan, M. J. Karplus, J. Comput. Chem. 1983, 4, 187-217.
- (1983) J. Comput. Chem , vol.4 , pp. 187-217
- Brooks, B.R.¹ Brucolleri, R.E.² Olafson, B.D.³ States, D.J.⁴ Swaminathan, S.⁵ Karplus, M.J.⁶

29
- 0003675575
- International University Line, La Jolla, CA
- O. F. Güner, Pharmacophore: Perception, Development and Use in Drug Design, International University Line, La Jolla, CA 2000.
- (2000) Pharmacophore: Perception, Development and Use in Drug Design
- Güner, O.F.¹

30
- 12444290270
- 8th ed, Hafner Publishing, New York, Chapter II
- R. Fischer, The Principle of Experimentation Illustrated by a Psycho-Physical Experiment, 8th ed, Hafner Publishing, New York, 1966, Chapter II.
- (1966) The Principle of Experimentation Illustrated by a Psycho-Physical Experiment
- Fischer, R.¹

31
- 77049125899
- homepage;
- InterBioScreen homepage; http://www.ibscreen.com.
- InterBioScreen

32
- 77049094152
- ChemStar homepage; http://www.chemstar.ru.
- ChemStar homepage; http://www.chemstar.ru.

33
- 33645251055
- Molecular Diversity Preservation International homepage; http:// www.mdpi.org.
- Molecular Diversity Preservation International homepage

34
- 77049113179
- Key Organics Ltd homepage; http://www.keyorganics.ltd.uk.
- Key Organics Ltd homepage

35
- 77049111995
- homepage;
- ASINEXs-Intelligent Chemistry homepage; http://www.asinex. com/welcome.htm.
- ASINEXs-Intelligent Chemistry

36
- 77049126131
- http://www.apps1.niaid.nih.gov/struct-search/an/an-search.htm.

37
- 77049103299
- homepage;
- Maybridge homepage; http://www.maybridge.com/html/ home.htm.
- Maybridge

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.