Bisphenol A-induced aromatase activation is mediated by cyclooxygenase-2 up-regulation in rat testicular Leydig cells

Toxicology Letters

Volumn 193, Issue 2, 2010, Pages 200-208

  Kim, Ji Young ^a   Han, Eun Hee ^b   Kim, Hyung Gyun ^b   Oh, Kyo Nyeo ^c   Kim, Sang Kyum ^b   Lee, Kwang Yeol ^a   Jeong, Hye Gwang ^b  

^a Chonnam National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Natural Resources Research Institute   (South Korea)

Author keywords

Aromatase; Bisphenol A; Cyclic AMP response element; Cyclooxygenase 2

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; AROMATASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; TESTOSTERONE SYNTHESIS;

ANIMALS; AROMATASE; CELL LINE; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LEYDIG CELLS; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; PHENOLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, PROSTAGLANDIN E; RNA, MESSENGER; UP-REGULATION;

RATTUS;

EID: 77049102125     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.01.011     Document Type: Article

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