Stem cell-related gene expression in clonal populations of mesenchymal stromal cells from bone marrow

Tissue Engineering - Part A

Volumn 16, Issue 2, 2010, Pages 749-758

  Mareddy, Shobha ^a   Dhaliwal, Navdeep ^a   Crawford, Ross ^a   Xiao, Yin ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOMATERIALS; BONE; CELL CULTURE; CELL PROLIFERATION; CLONE CELLS; FLOWCHARTING; GENE EXPRESSION; MAINTENANCE; PEPTIDES; POLYMERASE CHAIN REACTION;

BONE MARROW; BONE MORPHOGENETIC PROTEIN-2; CELL DIVISION CYCLE; CELL-FATE; CHONDROGENESIS; CLINICAL APPLICATION; CLONAL POPULATION; DEGENERATIVE DISEASE; EX VIVO EXPANSION; EXPRESSED GENES; FIBROBLAST GROWTH FACTOR 2; GENETIC MARKERS; GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR; MESENCHYMAL STEM CELL; MESENCHYMAL STROMAL CELLS; MOLECULAR PROCESS; MULTIPOTENTIAL CELLS; NEURAL STEM CELL; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; STEM CELL;

STEM CELLS;

ARTICLE; BONE MARROW CELL; CELL AGING; CELL CLONE; CELL PROLIFERATION; CYTOLOGY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KARYOTYPING; MESENCHYMAL STEM CELL; METABOLISM; STROMA CELL; TIME; UPREGULATION;

BONE MARROW CELLS; CELL AGING; CELL PROLIFERATION; CLONE CELLS; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; KARYOTYPING; MESENCHYMAL STEM CELLS; STROMAL CELLS; TIME FACTORS; UP-REGULATION;

EID: 77049101566     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0307     Document Type: Conference Paper

References (63)

1. Ohgushi, H., and Caplan, A.I. Stem cell technology and bioceramics: from cell to gene engineering. J Biomed Mater Res 48, 913, 1999.
2. Banfi, A., Muraglia, A., Dozin, B., Mastrogiacomo, M., Can-cedda, R., and Quarto, R. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy. Exp Hematol 28, 707, 2000.
3. Tokalov, S.V., Gruner, S., Schindler, S., Wolf, G., Baumann, M., and Abolmaali, N. Age-related changes in the frequency of mesenchymal stem cells in the bone marrow of rats. Stem Cells Dev 16, 439, 2007.
4. Bruder, S.P., Jaiswal, N., and Haynesworth, S.E. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcul-tivation and following cryopreservation. J Cell Biochem 64, 278, 1997.
5. Digirolamo, C.M., Stokes, D., Colter, D., Phinney, D.G., Class, R., and Prockop, D.J. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 107, 275, 1999.
6. D'Ippolito, G., Schiller, P.C., Ricordi, C., Roos, B.A., and Howard, G.A. Age-related osteogenic potential of mesenchy-mal stromal stem cells from human vertebral bone marrow. J Bone Miner Res 14, 1115, 1999.
7. Oreffo, R.O., Bord, S., and Triffitt, J.T. Skeletal progenitor cells and ageing human populations. Clin Sci 94, 549, 1998.
8. Quarto, R., Thomas, D., and Liang, C.T. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif Tissue Int 56, 123, 1995.
9. Phinney, D.G., Kopen, G., Righter, W., Webster, S., Tremain, N., and Prockop, D.J. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem 75, 424, 1999.
10. Kuznetsov, S.A., Krebsbach, P.H., Satomura, K., Kerr, J., Riminucci, M., Benayahu, D., and Robey, P.G. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res 12, 1335, 1997.
11. Mareddy, S., Crawford, R., Brooke, G., and Xiao, Y. Clonal isolation and characterization of bone marrow stromal cells from patients with osteoarthritis. Tissue Eng 13, 819, 2007.
12. Verfaillie, C.M., Miller, W.J., Boylan, K., and McGlave, P.B. Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression. Blood 79, 1003, 1992.
13. Yuan, J.S., Reed, A., Chen, F., and Stewart, C.N., Jr. Statistical analysis of real-time PCR data. BMC Bioinform 7, 85, 2006.
14. Jiang, Y., Jahagirdar, B.N., Reinhardt, R.L., Schwartz, R.E., Keene, C.D., Ortiz-Gonzalez, X.R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J., Aldrich, S., Lisberg, A., Low, W.C., Largaespada, D.A., and Verfaillie, C.M. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41, 2002.
15. Serafini, M., and Verfaillie, C.M. Pluripotency in adult stem cells: state of the art. Semin Reprod Med 24, 379, 2006.
16. Jeong, J.A., Hong, S.H., Gang, E.J., Ahn, C., Hwang, S.H., Yang, I.H., Han, H., and Kim, H. Differential gene expression profiling of human umbilical cord blood-derived mesenchy-mal stem cells by DNA microarray. Stem Cells 23, 584, 2005.
17. Salasznyk, R.M., Westcott, A.M., Klees, R.F., Ward, D.F., Xiang, Z., Vandenberg, S., Bennett, K., and Plopper, G.E. Comparing the protein expression profiles of human mes-enchymal stem cells and human osteoblasts using gene ontologies. Stem Cells Dev 14, 354, 2005.
18. Wagner, W., Wein, F., Seckinger, A., Frankhauser, M., Wir-kner, U., Krause, U., Blake, J., Schwager, C., Eckstein, V., Ansorge, W., and Ho, A.D. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 33, 1402, 2005.
19. Ulloa-Montoya, F., Kidder, B.L., Pauwelyn, K.A., Chase, L.G., Luttun, A., Crabbe, A., Geraerts, M., Sharov, A.A., Piao, Y., Ko, M.S., Hu, W.S., and Verfaillie, C.M. Comparative transcrip-tome analysis ofembryonic and adult stem cells with extended and limited differentiation capacity. GenomeBiol8,R163, 2007.
20. Liu, T.M., Martina, M., Hutmacher, D.W., Hui, J.H., Lee, E.H., and Lim, B. Identification of common pathways mediating differentiation of bone marrow-and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 25, 750, 2007.
21. de Jong, D.S., Vaes, B.L., Dechering, K.J., Feijen, A., Hendriks, J.M., Wehrens, R., Mummery, C.L., van Zoelen, E.J., Olijve, W., and Steegenga, W.T. Identification of novel regulators associated with early-phase osteoblast differentiation. J Bone Miner Res 19, 947, 2004.
22. Kulterer, B., Friedl, G., Jandrositz, A., Sanchez-Cabo, F., Prokesch, A., Paar, C., Scheideler, M., Windhager, R., Pre-isegger, K.H., and Trajanoski, Z. Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics 8, 70, 2007.
23. Song, L., Webb, N.E., Song, Y., and Tuan, R.S. Identification and functional analysis of candidate genes regulating mes-enchymal stem cell self-renewal and multipotency. Stem Cells 24, 1707, 2006.
24. Gregory, C.A., Ylostalo, J., and Prockop, D.J. Adult bone marrow stem=progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate. Sci STKE 2005, pe37, 2005.
25. Wan, H., Xu, Y., Ikegami, M., Stahlman, M.T., Kaestner, K.H., Ang, S.L., and Whitsett, J.A. Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci USA 101, 14449, 2004.
26. Sandell, L.J., and Adler, P. Developmental patterns of cartilage. Front Biosci 4, D731, 1999.
27. Duncan, A.W., Rattis, F.M., DiMascio, L.N., Congdon, K.L., Pazianos, G., Zhao, C., Yoon, K., Cook, J.M., Willert, K., Gaiano, N., and Reya, T. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 6, 314, 2005.
28. Conboy, I.M., Conboy, M.J., Wagers, A.J., Girma, E.R., Weissman, I.L., and Rando, T.A. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760, 2005.
29. Martin, I., Muraglia, A., Campanile, G., Cancedda, R., and Quarto, R. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138, 4456, 1997.
30. Nurse, P. The Wellcome Lecture, 1992. Cell cycle control. Philos Trans R Soc Lond B Biol Sci 341, 449, 1993.
31. Molofsky, A.V., Pardal, R., and Morrison, S.J. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol 16, 700, 2004.
32. Tremain, N., Korkko, J., Ibberson, D., Kopen, G.C., DiGir-olamo, C., and Phinney, D.G. MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undiffer-entiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells 19, 408, 2001.
33. Zaragosi, L.E., Ailhaud, G., and Dani, C. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 24, 2412, 2006.
34. Mastrogiacomo, M., Cancedda, R., and Quarto, R. Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells. Osteoarthritis Cartilage 9 Suppl A, S36, 2001.
35. Ito, T., Sawada, R., Fujiwara, Y., Seyama, Y., and Tsuchiya, T. FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2. Bio-chem Biophys Res Commun 359, 108, 2007.
36. Bianchi, G., Banfi, A., Mastrogiacomo, M., Notaro, R., Luz-zatto, L., Cancedda, R., and Quarto, R. Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res 287, 98, 2003.
37. Dalton, S. Cell cycle regulation of the human cdc2 gene. EMBO J 11, 1797, 1992.
38. Kato, Y., and Iwamoto, M. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J Biol Chem 265, 5903, 1990.
39. Twal, W.O., Vasilatos-Younken, R., Gay, C.V., and Leach, R.M., Jr. Isolation and localization of basic fibroblast growth factor-immunoreactive substance in the epiphyseal growth plate. J Bone Miner Res 9, 1737, 1994.
40. Molteni, A., Modrowski, D., Hott, M., and Marie, P.J. Differential expression of fibroblast growth factor receptor-1,-2, and-3 and syndecan-1,-2, and-4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro. Bone 24, 337, 1999.
41. Molofsky, A.V., Pardal, R., and Morrison, S.J. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol 16, 700, 2004.
42. Graham, V., Khudyakov, J., Ellis, P., and Pevny, L. SOX2 functions to maintain neural progenitor identity. Neuron 39, 749, 2003.
43. Mansukhani, A., Ambrosetti, D., Holmes, G., Cornivelli, L., and Basilico, C. Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol 168, 1065, 2005.
44. Whitsett, J.A, and Matsuzaki, Y. Transcriptional regulation of perinatal lung maturation. Pediatr Clin North Am 53,873,2006.
45. Kittappa, R., Chang, W.W., Awatramani, R.B., and McKay, R.D. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5, e325, 2007.
46. Quarto, R., Campanile, G., Cancedda, R., and Dozin, B. Modulation of commitment, proliferation, and differentiation of chondrogenic cells in defined culture medium. Endocrinology 138, 4966, 1997.
47. Hill, D.J. Stimulation of cartilage zones of the calf costo-chondral growth plate in vitro by growth hormone dependent rat plasma somatomedin activity. J Endocrinol 83, 219,1979.
48. Bondy, C.A., and Cheng, CM. Signaling by insulin-like growth factor 1 in brain. Eur J Pharmacol 490, 25, 2004.
49. Shetty, A.K., Hattiangady, B., and Shetty, G.A. Stem/ progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes. Glia 51, 173, 2005.
50. Sonntag, W.E., Ramsey, M., and Carter, C.S. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev 4, 195, 2005.
51. Rosen, V., and Thies, R.S. The BMP proteins in bone formation and repair. Trends Genet 8, 97, 1992.
52. Hanada, K., Dennis, J.E., and Caplan, A.I. Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derivedmesenchymalstemcells.JBoneMinerRes12, 1606,1997.
53. Tuan, R.S., Boland, G., and Tuli, R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 5, 32, 2003.
54. Kanzler, B., Foreman, R.K., Labosky, P.A., and Mallo, M. BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest. Development 127, 1095, 2000.
55. Calvi, L.M., Adams, G.B., Weibrecht, K.W., Weber, J.M., Olson, D.P., Knight, M.C., Martin, R.P., Schipani, E., Divieti, P., Bringhurst, F.R., Milner, L.A., Kronenberg, H.M., and Scadden, D.T. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841, 2003.
56. Hansen, D., Wilson-Berry, L., Dang, T., and Schedl, T. Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development 131, 93, 2004.
57. Crowe, R., Zikherman, J., and Niswander, L. Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation. Development 126, 987, 1999.
58. Hardingham, T.E., Oldershaw, R.A., and Tew, S.R. Cartilage, SOX9 and Notch signals in chondrogenesis. J Anat 209, 469, 2006.
59. Dowthwaite, G.P., Bishop, J.C., Redman, S.N., Khan, I.M., Rooney, P., Evans, D.J., Haughton, L., Bayram, Z., Boyer, S., Thomson, B., Wolfe, M.S., and Archer, C.W. The surface of articular cartilage contains a progenitor cell population. J Cell Sci 117, 889, 2004.
60. Bulman, M.P., Kusumi, K., Frayling, T.M., McKeown, C., Garrett, C., Lander, E.S., Krumlauf, R., Hattersley, A.T., Ellard, S., and Turnpenny, P.D. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet 24, 438, 2000.
61. Hermansson, M., Sawaji, Y., Bolton, M., Alexander, S., Wallace, A., Begum, S., Wait, R., and Saklatvala, J. Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes. J Biol Chem 279, 43514, 2004.
62. Foster, C.S., Cornford, P., Forsyth, L., Djamgoz, M.B., and Ke, Y. The cellular and molecular basis of prostate cancer. BJU Int 83, 171, 1999.
63. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.