The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells

Acta Pharmacologica Sinica

Volumn 31, Issue 2, 2010, Pages 211-218

  Cheng, Li Ming ^a   Jiang, Jian Gang ^a   Sun, Zi Yong ^a   Chen, Chen ^a   Dackor, Ryan T ^b   Zeldin, Darryl C ^b   Wang, Dao Wen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

AG1478; Arachidonic acid; CRM197; Cytochrome P450 epoxygenase; EGF R; Epoxyeicosatrienoic acids; ERK1 2; Metalloproteinase; Phenanthroline; Tumor cell proliferation

Indexed keywords

1,10 PHENANTHROLINE; 14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CYTOCHROME P450; DIPHTHERIA TOXOID CRM197; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TYROSINE;

ADENO ASSOCIATED VIRUS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; TRANSACTIVATION;

ARACHIDONIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; METALLOPROTEASES; PHENANTHROLINES; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTIONAL ACTIVATION;

EID: 76949099312     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.184     Document Type: Article

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