Primary cutaneous B-cell lymphoma is associated with somatically hypermutated immunoglobulin variable genes and frequent use of VH1-69 and VH4-59 segments

British Journal of Dermatology

Volumn 162, Issue 3, 2010, Pages 611-618

  Perez, M ^a   Pacchiarotti, A ^a   Frontani, M ^a   Pescarmona, E ^b   Caprini, E ^a   Lombardo, G A ^a   Russo, G ^a   Faraggiana, T ^a,b  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Clonal immunoglobulin rearrangements; Primary cutaneous B cell lymphoma; Somatic mutations; VH gene usage

Indexed keywords

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; FEMALE; GENE; GENE REARRANGEMENT; HISTOPATHOLOGY; HUMAN; IGV GENE; IMMUNOGLOBULIN VARIABLE REGION; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MARGINAL ZONE LYMPHOMA; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SOMATIC MUTATION; ANALYSIS OF VARIANCE; DNA SEQUENCE; GENETICS; IMMUNOGLOBULIN GENE; IMMUNOLOGY; MIDDLE AGED; POLYMERASE CHAIN REACTION; SKIN TUMOR; SOMATIC HYPERMUTATION; VERY ELDERLY;

IMMUNOGLOBULIN VARIABLE REGION;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SKIN NEOPLASMS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 76949097528     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09576.x     Document Type: Article

References (41)

1. Kuppers R, Klein U, Hansmann ML et al. Cellular origin of human B-cell lymphomas. N Engl J Med 1999 341 : 1520 1529.
2. Stevenson F, Sahota S, Zhu D et al. Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes. Immunol Rev 1998 162 : 247 259.
3. Walsh SH, Rosenquist R. Immunoglobulin gene analysis of mature B-cell malignancies: reconsideration of cellular origin and potential antigen involvement in pathogenesis. Med Oncol 2005 22 : 327 341.
4. Fais F, Ghiotto F, Hashimoto S et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998 102 : 1515 1525.
5. Hamblin TJ, Davis Z, Gardiner A et al. Unmutated IgV(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999 94 : 1848 1854.
6. Kienle D, Krober A, Katzenberger T et al. VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood 2003 102 : 3003 3009.
7. Tierens A, Delabie J, Pittaluga S et al. Mutation analysis of the rearranged immunoglobulin heavy chain genes of marginal zone cell lymphomas indicates an origin from different marginal zone B lymphocyte subsets. Blood 1998 91 : 2381 2386.
8. Dunn-Walters D, Thiede C, Alpen B, Spencer J. Somatic hypermutation and B-cell lymphoma. Philos Trans R Soc Lond B Biol Sci 2001 356 : 73 82.
9. Hashimoto T, Takishita M, Kosaka M et al. Superantigens and autoantigens may be involved in the pathogenesis of gastric mucosa-associated lymphoid tissue lymphoma. Int J Hematol 2001 74 : 197 204.
10. Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995 155 : 190 202.
11. Foreman AL, Van de Water J, Gougeon ML et al. B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage. Autoimmun Rev 2007 6 : 387 401.
12. Miklos JA, Swerdlow SH, Bahler DW. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features. Blood 2000 95 : 3878 3884.
13. Chan CH, Hadlock KG, Foung SK et al. V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen. Blood 2001 97 : 1023 1026.
14. Algara P, Mateo MS, Sanchez-Beato M et al. Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course. Blood 2002 99 : 1299 1304.
15. Montesinos-Rongen M, Kuppers R, Schluter D et al. Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment. Am J Pathol 1999 155 : 2077 2086.
16. Walsh SH, Thorselius M, Johnson A et al. Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood 2003 101 : 4047 4054.
17. Cerroni L. Lymphoproliferative lesions of the skin. J Clin Pathol 2006 59 : 813 826.
18. Willemze R, Jaffe ES, Burg G et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005 105 : 3768 3785.
19. Swerdlow S, Campo E, Harris N et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. Lyon : International Agency for Research on Cancer Press, 2008.
20. Aarts WM, Willemze R, Bende RJ et al. VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching. Blood 1998 92 : 3857 3864.
21. Bahler DW, Kim BK, Gao A et al. Analysis of immunoglobulin V genes suggests cutaneous marginal zone B-cell lymphomas recognise similar antigens. Br J Haematol 2006 132 : 571 575.
22. Franco R, Camacho FI, Fernandez-Vazquez A et al. IgV(H) and Bcl6 somatic mutation analysis reveals the heterogeneity of cutaneous B-cell lymphoma, and indicates the presence of undisclosed local antigens. Mod Pathol 2004 17 : 623 630.
23. Gellrich S, Rutz S, Golembowski S et al. Primary cutaneous follicle center cell lymphomas and large B cell lymphomas of the leg descend from germinal center cells. A single cell polymerase chain reaction analysis. J Invest Dermatol 2001 117 : 1512 1520.
24. van Dongen JJ, Langerak AW, Bruggemann M et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003 17 : 2257 2317.
25. Lefranc MP. IMGT, the International ImMunoGeneTics database. Nucleic Acids Res 2003 31 : 307 310.
26. Matsuda F, Shin EK, Nagaoka H et al. Structure and physical map of 64 variable segments in the 3′0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 1993 3 : 88 94.
27. Lossos IS, Tibshirani R, Narasimhan B et al. The inference of antigen selection on Ig genes. J Immunol 2000 165 : 5122 5126.
28. Tschumper RC, Geyer SM, Campbell ME et al. Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients. J Clin Invest 2008 118 : 306 315.
29. Lossos IS, Okada CY, Tibshirani R et al. Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas. Blood 2000 95 : 1797 1803.
30. Krober A, Seiler T, Benner A et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002 100 : 1410 1416.
31. Child FJ, Scarisbrick JJ, Calonje E et al. Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma. J Invest Dermatol 2002 118 : 941 948.
32. Dijkman R, Tensen CP, Jordanova ES et al. Array-based comparative genomic hybridization analysis reveals recurrent chromosomal alterations and prognostic parameters in primary cutaneous large B-cell lymphoma. J Clin Oncol 2006 24 : 296 305.
33. Senff NJ, Zoutman WH, Vermeer MH et al. Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large B-cell lymphoma, leg type. J Invest Dermatol 2009 129 : 1149 1155.
34. Bende RJ, Aarts WM, Riedl RG et al. Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J Exp Med 2005 201 : 1229 1241.
35. Efremov DG, Ivanovski M, Siljanovski N et al. Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia. Blood 1996 87 : 3869 3876.
36. Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997 158 : 235 246.
37. Rosenquist R, Lindstrom A, Holmberg D et al. V(H) gene family utilization in different B-cell lymphoma subgroups. Eur J Haematol 1999 62 : 123 128.
38. Ivanovski M, Silvestri F, Pozzato G et al. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas. Blood 1998 91 : 2433 2442.
39. Marasca R, Vaccari P, Luppi M et al. Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma. Am J Pathol 2001 159 : 253 261.
40. Carbonari M, Caprini E, Tedesco T et al. Hepatitis C virus drives the unconstrained monoclonal expansion of VH1-69-expressing memory B cells in type II cryoglobulinemia: a model of infection-driven lymphomagenesis. J Immunol 2005 174 : 6532 6539.
41. Camacho FI, Algara P, Rodriguez A et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood 2003 101 : 4042 4046.