Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo

International Journal of Molecular Medicine

Volumn 25, Issue 3, 2010, Pages 347-352

  Cho, Jae We ^a   Cho, So Young ^a   Lee, Seong Ryong ^b   Lee, Kyu Suk ^a  

^a Keimyung University School of Medicine   (South Korea)

^b Keimyung University   (South Korea)

Author keywords

Fibroblasts; Matrix metalloproteinase 1; Onion extract; Quercetin

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 1; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; ONION EXTRACT; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; ENZYME INDUCTION; EXTRACELLULAR MATRIX; GENE EXPRESSION; HAIRLESS MOUSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHOTOAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR; SKIN FIBROBLAST; ULTRAVIOLET B RADIATION;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CICATRIX; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KAEMPFEROLS; MATRIX METALLOPROTEINASE 1; MICE; MICE, NUDE; ONIONS; PLANT EXTRACTS; QUERCETIN; SKIN; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 76949094689     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000351     Document Type: Article

References (18)

1. Ross JA and Kasum CM: Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22: 19-34, 2002.
2. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R and Kinae N: Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 30: 2243-2250, 2000.
3. Saric A, Balog T, Sobocanec S, et al: Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen. Food Chem Toxicol 47: 547-554, 2009.
4. Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT and Lee MT: The antitumor activities of flavonoids. In Vivo 19: 895-909, 2005.
5. Hosnuter M, Payasli C, Isikdemir A and Tekerekoglu B: The effects of onion extract on hypertrophic and keloid scars. J Wound Care 16: 251-254, 2007.
6. Ho WS, Ying SY, Chan PC and Chan HH: Use of onion extract, heparin, allantoin gel in prevention of scarring in Chinese patients having laser removal of tattoos: a prospective randomized controlled trial. Dermatol Surg 32: 891-896, 2006.
7. Bran GM, Goessler UR, Hormann K, Riedel F and Sadick H: Keloids: Current concepts of pathogenesis (Review). Int J Mol Med 24: 283-293, 2009.
8. Seifert O and Mrowietz U: Keloid scarring: bench and bedside. Arch Dermatol Res 301: 259-272, 2009.
9. Gill SE and Parks WC: Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol 40: 1334-1337, 2008.
10. Peled ZM, Phelps ED, Updlike DL, et al: Matrix metalloproteinases and the ontogeny of scarless repair: the other side of the wound healing balance. Plast Reconstr Surg 110: 801-811, 2002.
11. Gu Q, Wang D, Gao Y, et al: Expression of MMP1 in surgical and radiation-impaired wound healing and its effects on the healing process. J Environ Pathol Toxicol Oncol 21: 71-78, 2002.
12. Majewski S and Chadzynska M: Effects of heparin, allantoin and cepae extract on the proliferation of keloid fibroblasts and other cells in vitro. Dermatol Monatsschr 174: 106-129, 1988.
13. Moon SK, Cho GO, Jung SY, et al: Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun 301: 1069-1078, 2003.
14. Leeman MF, Curran S and Murray GI: New insights into the roles of matrix metalloproteinases in colorectal cancer development and progression. J Pathol 201: 528-534, 2003.
15. Moon HI, Lee JG, Kwak JH and Chung JH: Isoflavonoid from Viola hondoensis, regulates the expression of matrix metallo-proteinase-1 in human skin fibroblasts. Biol Pharm Bull 28: 925-928, 2005.
16. Westermarck J, Holmstrom T, Ahonen T, et al: Enhancement of fibroblast collagenase-1 (MMP-I) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38. Matrix Biol 17: 547-557, 1998.
17. Moon HJ, Lee SR, Shin SN, et al: Fucoidan inhibits UVB-induced MMP-1 expression in human skin fibroblasts. Biol Pharm Bull 31: 284-289, 2008.
18. Yang B, Ji C, Chen W, Bi Z and Wan Y: Trans-zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinases signaling in human skin fibroblasts. Int J Mol Med 23: 555-560, 2009.