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Volumn 118, Issue 8, 2010, Pages 487-506

Gene variants of the renin-angiotensin system and hypertension: From a trough of disillusionment to a welcome phase of enlightenment?

Author keywords

Angiotensin converting enzyme (ACE); Angiotensinogen (AGT); Gene; Human hypertension; Renin angiotensin system (RAS)

Indexed keywords

ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE;

EID: 76849116545     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090498     Document Type: Review
Times cited : (15)

References (106)
  • 1
    • 34250350040 scopus 로고    scopus 로고
    • Mancia, G., de Backer, G., Dominiczak, A., Cifkova, R., Germano, G., Grassi, G., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., Narkiewitcz, K. et al. (2007) 2007 Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 6, 1105-1187
    • Mancia, G., de Backer, G., Dominiczak, A., Cifkova, R., Germano, G., Grassi, G., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., Narkiewitcz, K. et al. (2007) 2007 Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 6, 1105-1187
  • 2
    • 26444590999 scopus 로고    scopus 로고
    • Racial disparities in hypertension prevalence, awareness and management
    • Hertz, R. P., Unger, A. N., Cornell, J. A. and Saunders, E. (2005) Racial disparities in hypertension prevalence, awareness and management. Arch. Intern. Med. 165, 2098-2104
    • (2005) Arch. Intern. Med , vol.165 , pp. 2098-2104
    • Hertz, R.P.1    Unger, A.N.2    Cornell, J.A.3    Saunders, E.4
  • 3
    • 59649120622 scopus 로고    scopus 로고
    • Effect of treatment and adherence on ethnic differences in blood pressure control among adults with hypertension
    • Natarajan, S., Santa Ana, E. J., Liao, Y., Lipsitz, S. R. and McGee, D. L. (2009) Effect of treatment and adherence on ethnic differences in blood pressure control among adults with hypertension. Ann. Epidemiol. 19, 172-179
    • (2009) Ann. Epidemiol , vol.19 , pp. 172-179
    • Natarajan, S.1    Santa Ana, E.J.2    Liao, Y.3    Lipsitz, S.R.4    McGee, D.L.5
  • 4
    • 0034806024 scopus 로고    scopus 로고
    • Hypertension in South African adults: Results from the Demographic and Health Survey, 1998
    • Steyn, K., Gaziano, T. A., Bradshaw, D., Laubscher, R. and Fourie, J. (2001) Hypertension in South African adults: results from the Demographic and Health Survey, 1998. J. Hypertens. 19, 1717-1725
    • (2001) J. Hypertens , vol.19 , pp. 1717-1725
    • Steyn, K.1    Gaziano, T.A.2    Bradshaw, D.3    Laubscher, R.4    Fourie, J.5
  • 6
    • 0035092195 scopus 로고    scopus 로고
    • Twins in cardiovascular genetic research
    • Luft, F. C. (2001) Twins in cardiovascular genetic research. Hypertension 37, 350-356
    • (2001) Hypertension , vol.37 , pp. 350-356
    • Luft, F.C.1
  • 7
    • 0029931632 scopus 로고    scopus 로고
    • Familial correlations, cohabitation effects, and heritability for cardiovascular risk factors
    • Knuiman, M. W., Divitini, M. L., Welborn, T. A. and Bartholomew, H. C. (1996) Familial correlations, cohabitation effects, and heritability for cardiovascular risk factors. Ann. Epidemiol. 6, 1007-1013
    • (1996) Ann. Epidemiol , vol.6 , pp. 1007-1013
    • Knuiman, M.W.1    Divitini, M.L.2    Welborn, T.A.3    Bartholomew, H.C.4
  • 8
    • 0035001426 scopus 로고    scopus 로고
    • The impact of genetic and environmental influences on blood pressure variance across age-groups
    • Vinck, W. J., Fagard, R. H., Loos, R. and Vlietinck, R. (2001) The impact of genetic and environmental influences on blood pressure variance across age-groups. J. Hypertens. 19, 1007-1013
    • (2001) J. Hypertens , vol.19 , pp. 1007-1013
    • Vinck, W.J.1    Fagard, R.H.2    Loos, R.3    Vlietinck, R.4
  • 10
    • 0032952468 scopus 로고    scopus 로고
    • Freely associating
    • Anonymous
    • Anonymous (1999) Freely associating. Nat. Genet. 22, 1-2
    • (1999) Nat. Genet , vol.22 , pp. 1-2
  • 11
    • 0032979840 scopus 로고    scopus 로고
    • Seven lessons from two candidate genes in human essential hypertension
    • Corvol, P., Persu, A., Gimenez-Roqueplo, A-P. and Jeunemaitre, X. J. (1999) Seven lessons from two candidate genes in human essential hypertension. Hypertension 33, 1324-1331
    • (1999) Hypertension , vol.33 , pp. 1324-1331
    • Corvol, P.1    Persu, A.2    Gimenez-Roqueplo, A.-P.3    Jeunemaitre, X.J.4
  • 12
    • 0033939866 scopus 로고    scopus 로고
    • The future of genetic association studies in hypertension: Improving the signal to noise ratio
    • Sharma, A. M. and Jeunemaitre, X. (2000) The future of genetic association studies in hypertension: improving the signal to noise ratio. J. Hypertens. 18, 811-814
    • (2000) J. Hypertens , vol.18 , pp. 811-814
    • Sharma, A.M.1    Jeunemaitre, X.2
  • 13
    • 0034700892 scopus 로고    scopus 로고
    • Association studies of genetic polymorphisms and complex disease
    • Gambaro, G., Anglani, F. and D'Angelo, A. (2000) Association studies of genetic polymorphisms and complex disease. Lancet 355, 308-311
    • (2000) Lancet , vol.355 , pp. 308-311
    • Gambaro, G.1    Anglani, F.2    D'Angelo, A.3
  • 14
    • 30544444526 scopus 로고    scopus 로고
    • Pharmacogenetics of hypertensive treatment
    • Arnett, D. K., Claas, S. A. and Glasser, S. P. (2006) Pharmacogenetics of hypertensive treatment. Vasc. Pharmacol. 44, 107-118
    • (2006) Vasc. Pharmacol , vol.44 , pp. 107-118
    • Arnett, D.K.1    Claas, S.A.2    Glasser, S.P.3
  • 15
    • 33845202134 scopus 로고    scopus 로고
    • Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension
    • Farahani, P., Dolovich, L. and Levine, M. (2007) Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension. J. Clin. Epidemiol. 60, 1-7
    • (2007) J. Clin. Epidemiol , vol.60 , pp. 1-7
    • Farahani, P.1    Dolovich, L.2    Levine, M.3
  • 16
    • 0037442092 scopus 로고    scopus 로고
    • Population stratification and spurious allelic association
    • Carden, L. R. and Palmer, L. J. (2003) Population stratification and spurious allelic association. Lancet 361, 598-604
    • (2003) Lancet , vol.361 , pp. 598-604
    • Carden, L.R.1    Palmer, L.J.2
  • 20
    • 4344628938 scopus 로고    scopus 로고
    • Heritability of ambulatory and office blood pressure phenotypes in Swedish families
    • Fava, C., Burri, P., Almgren, P., Groop, L., Lennart Huthen, U. and Melander, O. (2004) Heritability of ambulatory and office blood pressure phenotypes in Swedish families. J. Hypertens. 22, 1717-1721
    • (2004) J. Hypertens , vol.22 , pp. 1717-1721
    • Fava, C.1    Burri, P.2    Almgren, P.3    Groop, L.4    Lennart Huthen, U.5    Melander, O.6
  • 24
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism of the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels
    • Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P. and Soubrier, F. (1990) An insertion/deletion polymorphism of the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels. J. Clin. Invest. 86, 1343-1346
    • (1990) J. Clin. Invest , vol.86 , pp. 1343-1346
    • Rigat, B.1    Hubert, C.2    Alhenc-Gelas, F.3    Cambien, F.4    Corvol, P.5    Soubrier, F.6
  • 25
    • 0026651907 scopus 로고
    • Evidence from combined segregation and linkage analysis that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels
    • Tiret, L., Rigat, B., Visvikis, S., Breda, C., Corvol, P., Cambien, F. and Soubrier, F. (1992) Evidence from combined segregation and linkage analysis that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am. J. Hum. Genet. 51, 197-205
    • (1992) Am. J. Hum. Genet , vol.51 , pp. 197-205
    • Tiret, L.1    Rigat, B.2    Visvikis, S.3    Breda, C.4    Corvol, P.5    Cambien, F.6    Soubrier, F.7
  • 27
    • 0029988937 scopus 로고    scopus 로고
    • Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis
    • Villard, E., Tiret, L., Visvikis, S., Rakotova, R., Cambien, F. and Soubrier, F. (1996) Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am. J. Hum. Genet. 58, 1268-1278
    • (1996) Am. J. Hum. Genet , vol.58 , pp. 1268-1278
    • Villard, E.1    Tiret, L.2    Visvikis, S.3    Rakotova, R.4    Cambien, F.5    Soubrier, F.6
  • 31
    • 0033960180 scopus 로고    scopus 로고
    • ACE gene polymorphism in cardiovascular disease: Meta-analyses of small and large studies in whites
    • Agerholm-Larsen, B., Nordestgaard, B. G. and Tybjaerg-Hansen, A. (2000) ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler. Thromb. Vasc. Biol. 20, 484-492
    • (2000) Arterioscler. Thromb. Vasc. Biol , vol.20 , pp. 484-492
    • Agerholm-Larsen, B.1    Nordestgaard, B.G.2    Tybjaerg-Hansen, A.3
  • 33
    • 0344193095 scopus 로고    scopus 로고
    • Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males
    • Fornage, M., Amos, C. I., Kardia, S., Sing, C. F., Turner, S. T. and Boerwinkle, E. (1998) Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males. Circulation. 97, 1773-1779
    • (1998) Circulation , vol.97 , pp. 1773-1779
    • Fornage, M.1    Amos, C.I.2    Kardia, S.3    Sing, C.F.4    Turner, S.T.5    Boerwinkle, E.6
  • 34
    • 0345486977 scopus 로고    scopus 로고
    • Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study
    • O'Donnell, C. J., Lindpainter, K., Larson, M. G., Rao, V. S., Ordovas, J. M., Schaefer, E. J., Myers, R. H. and Levy, D. (1998) Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 97, 1766-1772
    • (1998) Circulation , vol.97 , pp. 1766-1772
    • O'Donnell, C.J.1    Lindpainter, K.2    Larson, M.G.3    Rao, V.S.4    Ordovas, J.M.5    Schaefer, E.J.6    Myers, R.H.7    Levy, D.8
  • 35
    • 0034595316 scopus 로고    scopus 로고
    • Deletion allele of the angiotensin-converting enzyme gene increases risk of essential hypertension in men: The Suita Study
    • Higaki, J., Baba, S., Katsuya, T., Sato, N., Ishikawa, K., Mannami, T., Ogata, J. and Ogihara, T. (2000) Deletion allele of the angiotensin-converting enzyme gene increases risk of essential hypertension in men: the Suita Study. Circulation 101, 2060-2065
    • (2000) Circulation , vol.101 , pp. 2060-2065
    • Higaki, J.1    Baba, S.2    Katsuya, T.3    Sato, N.4    Ishikawa, K.5    Mannami, T.6    Ogata, J.7    Ogihara, T.8
  • 37
    • 0842348050 scopus 로고    scopus 로고
    • Does angiotensin-converting enzyme gene polymorphism affect blood pressure? Findings after 6 years of follow-up in healthy subjects
    • Di Pasquale, P., Cannizzaro, S. and Paterna, S. (2004) Does angiotensin-converting enzyme gene polymorphism affect blood pressure? Findings after 6 years of follow-up in healthy subjects. Eur. J. Heart Failure 6, 611-616
    • (2004) Eur. J. Heart Failure , vol.6 , pp. 611-616
    • Di Pasquale, P.1    Cannizzaro, S.2    Paterna, S.3
  • 38
    • 0026849428 scopus 로고
    • Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension
    • Jeunemaitre, X., Lifton, R., Hunt, S. C., Williams, R. R. and Lalouel, J-M. (1992) Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat. Genet. 1, 72-75
    • (1992) Nat. Genet , vol.1 , pp. 72-75
    • Jeunemaitre, X.1    Lifton, R.2    Hunt, S.C.3    Williams, R.R.4    Lalouel, J.-M.5
  • 39
    • 0030910853 scopus 로고    scopus 로고
    • ACE gene polymorphism: Ischaemic heart disease and longevity in 10,150 individuals: a case referent and retrospective cohort study based on the Copenhagen City Heart Study
    • Agerholm-Larsen, B., Nordestgaard, B. G., Steffensen, R., Sorensen, T. A., Jensen, G. and Tybjaerg-Hansen, A. (1997) ACE gene polymorphism: ischaemic heart disease and longevity in 10,150 individuals: a case referent and retrospective cohort study based on the Copenhagen City Heart Study. Circulation 95, 2358-2367
    • (1997) Circulation , vol.95 , pp. 2358-2367
    • Agerholm-Larsen, B.1    Nordestgaard, B.G.2    Steffensen, R.3    Sorensen, T.A.4    Jensen, G.5    Tybjaerg-Hansen, A.6
  • 41
    • 12444304381 scopus 로고    scopus 로고
    • Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population. The GENIPER Project
    • Castellano, M., Glorioso, N., Cusi, D., Sarzani, R., Fabris, B., Opoocher, G., Zoccali, C., Golin, R., Veglio, F., Volpe, M. et al. (2003) Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population. The GENIPER Project. J. Hypertens. 21, 1853-1860
    • (2003) J. Hypertens , vol.21 , pp. 1853-1860
    • Castellano, M.1    Glorioso, N.2    Cusi, D.3    Sarzani, R.4    Fabris, B.5    Opoocher, G.6    Zoccali, C.7    Golin, R.8    Veglio, F.9    Volpe, M.10
  • 43
    • 0035139696 scopus 로고    scopus 로고
    • Angiotensin converting enzyme genetic polymorphism is not associated with hypertension in a cross-sectional sample of a Japanese population: The Shibata Study
    • Zaman, M. M., Yoshiike, N., Date, C., Yokoyama, T., Matsumura, Y., Ikemoto, S. and Tanaka, H. (2001) Angiotensin converting enzyme genetic polymorphism is not associated with hypertension in a cross-sectional sample of a Japanese population: The Shibata Study. J. Hypertens. 19, 47-53
    • (2001) J. Hypertens , vol.19 , pp. 47-53
    • Zaman, M.M.1    Yoshiike, N.2    Date, C.3    Yokoyama, T.4    Matsumura, Y.5    Ikemoto, S.6    Tanaka, H.7
  • 44
    • 14644404384 scopus 로고    scopus 로고
    • Polymorphisms of the insertion/deletion ACE and M235T AGT genes and hypertension: Surprising new findings and meta-analysis
    • Mondry, A., Loh, M., Liu, P., Zhu, A-L. and Nagel, M. (2005) Polymorphisms of the insertion/deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis. BMC Nephrol. 6, 1
    • (2005) BMC Nephrol , vol.6 , pp. 1
    • Mondry, A.1    Loh, M.2    Liu, P.3    Zhu, A.-L.4    Nagel, M.5
  • 46
    • 9644258901 scopus 로고    scopus 로고
    • Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17 and 22
    • de Lange, M., Spector, T. D. and Andrew, T. (2004) Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17 and 22. Hypertension 44, 872-877
    • (2004) Hypertension , vol.44 , pp. 872-877
    • de Lange, M.1    Spector, T.D.2    Andrew, T.3
  • 49
    • 34248658252 scopus 로고    scopus 로고
    • Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure
    • Jacobs, K. B., Gray-McGuire, C., Cartier, K. C. and Elston, R. C. (2003) Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure. BMC Genet. 4 (Suppl. 1), S82-S86
    • (2003) BMC Genet , vol.4 , Issue.SUPPL. 1
    • Jacobs, K.B.1    Gray-McGuire, C.2    Cartier, K.C.3    Elston, R.C.4
  • 50
    • 0033770421 scopus 로고    scopus 로고
    • Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study
    • Levy, D., DeStefano, A. L., Larson, M. G., O'Donnell, C. J., Lifton, R. P., Gavras, H., Cupples, L. A. and Myers, R. H. (2000) Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension 36, 477-483
    • (2000) Hypertension , vol.36 , pp. 477-483
    • Levy, D.1    DeStefano, A.L.2    Larson, M.G.3    O'Donnell, C.J.4    Lifton, R.P.5    Gavras, H.6    Cupples, L.A.7    Myers, R.H.8
  • 53
    • 4444294188 scopus 로고    scopus 로고
    • Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study
    • Wilk, J. B., Djousse, L., Arnett, D. K., Hunt, S. C., Province, M. A., Heiss, G. and Myers, R. H. (2004) Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study. Am. J. Hypertens. 17, 839-844
    • (2004) Am. J. Hypertens , vol.17 , pp. 839-844
    • Wilk, J.B.1    Djousse, L.2    Arnett, D.K.3    Hunt, S.C.4    Province, M.A.5    Heiss, G.6    Myers, R.H.7
  • 54
  • 55
    • 21644449270 scopus 로고    scopus 로고
    • Genetic effects on blood pressure localized to chromosomes 6 and 7
    • Adeyemo, A., Luke, A., Wu, X., Cooper, R. S., Kan, D., Omotade, O. and Zhu, X. (2005) Genetic effects on blood pressure localized to chromosomes 6 and 7. J. Hypertens. 23, 1367-1373
    • (2005) J. Hypertens , vol.23 , pp. 1367-1373
    • Adeyemo, A.1    Luke, A.2    Wu, X.3    Cooper, R.S.4    Kan, D.5    Omotade, O.6    Zhu, X.7
  • 57
    • 3543026302 scopus 로고    scopus 로고
    • Genome-wide scan for pulse pressure in the National Heart, Lung and Blood Institute's Framingham Heart Study
    • DeStefano, A. L., Larson, M. G., Mitchell, G. F., Benjamin, E. J., Vasan, R. S., Li, J., Corey, D. and Levy, D. (2004) Genome-wide scan for pulse pressure in the National Heart, Lung and Blood Institute's Framingham Heart Study. Hypertension 44, 152-155
    • (2004) Hypertension , vol.44 , pp. 152-155
    • DeStefano, A.L.1    Larson, M.G.2    Mitchell, G.F.3    Benjamin, E.J.4    Vasan, R.S.5    Li, J.6    Corey, D.7    Levy, D.8
  • 58
    • 0037629012 scopus 로고    scopus 로고
    • Evaluating the context-dependent effect of family history of stroke in a genome scan for hypertension
    • Morrison, A. C., Brown, A., Kardia, S. L. R., Turner, S. T. and Boerwinkle, E. (2003) Evaluating the context-dependent effect of family history of stroke in a genome scan for hypertension. Stroke 34, 1170-1175
    • (2003) Stroke , vol.34 , pp. 1170-1175
    • Morrison, A.C.1    Brown, A.2    Kardia, S.L.R.3    Turner, S.T.4    Boerwinkle, E.5
  • 60
    • 68249107559 scopus 로고    scopus 로고
    • Adeyemo, A., Gerry, N., Chen, G., Herbert, A., Doumatey, A., Huang, H., Zhou, J., Lashley, K., Chen, Y., Christman, M. and Rotimi, C. (2009) A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet. 5, e1000564
    • Adeyemo, A., Gerry, N., Chen, G., Herbert, A., Doumatey, A., Huang, H., Zhou, J., Lashley, K., Chen, Y., Christman, M. and Rotimi, C. (2009) A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet. 5, e1000564
  • 61
    • 70450227480 scopus 로고    scopus 로고
    • Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study
    • Ehret, G. B., O'Connor, A. A., Weder, A., Cooper, R. S. and Chakravarti, A. (2009) Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. Eur. J. Hum. Genet. 17, 1650-1657
    • (2009) Eur. J. Hum. Genet , vol.17 , pp. 1650-1657
    • Ehret, G.B.1    O'Connor, A.A.2    Weder, A.3    Cooper, R.S.4    Chakravarti, A.5
  • 62
    • 66149105886 scopus 로고    scopus 로고
    • Org, E., Eyheramendy, S., Juhanson, P., Gieger, C., Lichtner, P., Klopp, N., Veldre, G., Doring, A., Viigimaa, M., Sober, S. et al. (2009) Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum. Mol. Genet. 18, 2288-2296
    • Org, E., Eyheramendy, S., Juhanson, P., Gieger, C., Lichtner, P., Klopp, N., Veldre, G., Doring, A., Viigimaa, M., Sober, S. et al. (2009) Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum. Mol. Genet. 18, 2288-2296
  • 63
    • 67650665283 scopus 로고    scopus 로고
    • Sober, S., Org, E., Kepp, K., Juhanson, P., Eyheramendy, S., Gieger, C., Lichtner, P., Klopp, N., Veldre, G., Viigimaa, M. et al. (2009) Targeting 160 candidate genes for blood pressure regulation with genome-wide genotyping array, PLoS ONE 4, e6034
    • Sober, S., Org, E., Kepp, K., Juhanson, P., Eyheramendy, S., Gieger, C., Lichtner, P., Klopp, N., Veldre, G., Viigimaa, M. et al. (2009) Targeting 160 candidate genes for blood pressure regulation with genome-wide genotyping array, PLoS ONE 4, e6034
  • 64
    • 84969213492 scopus 로고    scopus 로고
    • The Wellcome Trust, Case Control Consortium (2007) Genome-wide association study of 14000 cases of seven common diseases and 3000 shared controls. Nature 447, 661-678
    • The Wellcome Trust, Case Control Consortium (2007) Genome-wide association study of 14000 cases of seven common diseases and 3000 shared controls. Nature 447, 661-678
  • 65
    • 0031037629 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis
    • Krege, J. H., Kim, H-S., Moyer, J. S., Jennette, J. C., Peng, L., Hiller, S. K. and Smithies, O. (1997) Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension 29, 150-157
    • (1997) Hypertension , vol.29 , pp. 150-157
    • Krege, J.H.1    Kim, H.-S.2    Moyer, J.S.3    Jennette, J.C.4    Peng, L.5    Hiller, S.K.6    Smithies, O.7
  • 66
    • 0029861799 scopus 로고    scopus 로고
    • The Y chromosome: Epistatic and ecogenetic interactions in genetic hypertension
    • Kreutz, R., Stock, P., Struk, B. and Linpainter, K. (1996) The Y chromosome: epistatic and ecogenetic interactions in genetic hypertension. Hypertension 28, 895-897
    • (1996) Hypertension , vol.28 , pp. 895-897
    • Kreutz, R.1    Stock, P.2    Struk, B.3    Linpainter, K.4
  • 67
    • 0032708761 scopus 로고    scopus 로고
    • Context-dependent associations of the ACE I/D polymorphism with blood pressure
    • Turner, S. T., Boerwinkle, E. and Sing, C. F. (1999) Context-dependent associations of the ACE I/D polymorphism with blood pressure. Hypertension 34, 773-778
    • (1999) Hypertension , vol.34 , pp. 773-778
    • Turner, S.T.1    Boerwinkle, E.2    Sing, C.F.3
  • 70
    • 1842475073 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme D/I gene polymorphism and age-related changes in pulse pressure in subjects with hypertension
    • Safar, M. E., Lajemi, M., Rudnichi, A., Asmar, R. and Benetos, A. (2004) Angiotensin I-converting enzyme D/I gene polymorphism and age-related changes in pulse pressure in subjects with hypertension. Arterioscler. Thromb. Vasc. Biol. 24, 782-786
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , pp. 782-786
    • Safar, M.E.1    Lajemi, M.2    Rudnichi, A.3    Asmar, R.4    Benetos, A.5
  • 71
    • 1842614374 scopus 로고    scopus 로고
    • Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension
    • Rudnichi, A., Safar, M. E., Lajemi, M. and Benetos, A. (2004) Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension. Am. J. Hypertens. 17, 321-327
    • (2004) Am. J. Hypertens , vol.17 , pp. 321-327
    • Rudnichi, A.1    Safar, M.E.2    Lajemi, M.3    Benetos, A.4
  • 73
    • 33847659558 scopus 로고    scopus 로고
    • Multilocus analyses of renin-angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioural stress in young normotensive subjects
    • Ge, D., Zhu, H., Huang, Y., Treiber, F. A., Harshfield, G. A., Snieder, H. and Dong,. (2007) Multilocus analyses of renin-angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioural stress in young normotensive subjects. Hypertension 49, 107-112
    • (2007) Hypertension , vol.49 , pp. 107-112
    • Ge, D.1    Zhu, H.2    Huang, Y.3    Treiber, F.A.4    Harshfield, G.A.5    Snieder, H.6    Dong7
  • 75
    • 0026574210 scopus 로고
    • Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: A four corners approach to the identification of genetic determinants of blood pressure
    • Watt, G. C., Harrap, S. B., Foy, C. J. W., Holton, D. W., Edwards, H. V., Davidson, H. R., Connor, J. M., Lever, A. F. and Fraser, R. (1992) Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four corners approach to the identification of genetic determinants of blood pressure. J. Hypertens. 10, 473-482
    • (1992) J. Hypertens , vol.10 , pp. 473-482
    • Watt, G.C.1    Harrap, S.B.2    Foy, C.J.W.3    Holton, D.W.4    Edwards, H.V.5    Davidson, H.R.6    Connor, J.M.7    Lever, A.F.8    Fraser, R.9
  • 77
    • 0036862309 scopus 로고    scopus 로고
    • Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregation-linkage analysis
    • Brand, E., Chatelain, N., Pailllard, F., Tiret, L., Visvikis, S., Lathrop, M., Soubrier, F. and Demenais, F. (2002) Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregation-linkage analysis. Eur. J. Hum. Genet. 10, 715-723
    • (2002) Eur. J. Hum. Genet , vol.10 , pp. 715-723
    • Brand, E.1    Chatelain, N.2    Pailllard, F.3    Tiret, L.4    Visvikis, S.5    Lathrop, M.6    Soubrier, F.7    Demenais, F.8
  • 78
    • 0037771145 scopus 로고    scopus 로고
    • Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischaemic heart disease: A meta-analysis
    • Sethi, A. A., Nordestgaardt, B. G. and Tybjaerg-Hansen, A. (2003) Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischaemic heart disease: a meta-analysis. Arterioscler. Thromb. Vasc. Biol. 23, 1269-1275
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 1269-1275
    • Sethi, A.A.1    Nordestgaardt, B.G.2    Tybjaerg-Hansen, A.3
  • 79
    • 0030893575 scopus 로고    scopus 로고
    • A nucleotide substitution in the promoters of human angiotensinogen is associated with essential hypertension and affects basal transcription
    • Inoue, I., Nakajima, T., Williams, C. S., Quackenbush, J., Puryear, R., Powers, M., Cheng, T., Ludwig, E. H., Sharma, A. M., Hata, A. et al. (1997) A nucleotide substitution in the promoters of human angiotensinogen is associated with essential hypertension and affects basal transcription. J. Clin. Invest. 99, 1786-1797
    • (1997) J. Clin. Invest , vol.99 , pp. 1786-1797
    • Inoue, I.1    Nakajima, T.2    Williams, C.S.3    Quackenbush, J.4    Puryear, R.5    Powers, M.6    Cheng, T.7    Ludwig, E.H.8    Sharma, A.M.9    Hata, A.10
  • 80
    • 0010610371 scopus 로고    scopus 로고
    • Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene
    • Zhao, Y. Y., Zhou, J., Narayanan, C. S., Cui, Y. and Kumar, A. (1999) Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene. Hypertension 33, 108-115
    • (1999) Hypertension , vol.33 , pp. 108-115
    • Zhao, Y.Y.1    Zhou, J.2    Narayanan, C.S.3    Cui, Y.4    Kumar, A.5
  • 82
    • 0037184109 scopus 로고    scopus 로고
    • Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans
    • Jain, S., Tang, X., Narayanan, C. S., Agarwal, Y., Peterson, S. M., Brown, C. D., Ott, J. and Kumar, A. (2002) Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans. J. Biol. Chem. 277, 36889-36896
    • (2002) J. Biol. Chem , vol.277 , pp. 36889-36896
    • Jain, S.1    Tang, X.2    Narayanan, C.S.3    Agarwal, Y.4    Peterson, S.M.5    Brown, C.D.6    Ott, J.7    Kumar, A.8
  • 83
    • 0018465575 scopus 로고
    • Relations between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects
    • Walker, W. G., Whelton, P. K., Saito, H., Russel, R. P. and Hermann, J. (1979) Relations between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension 1, 287-291
    • (1979) Hypertension , vol.1 , pp. 287-291
    • Walker, W.G.1    Whelton, P.K.2    Saito, H.3    Russel, R.P.4    Hermann, J.5
  • 88
    • 0035103960 scopus 로고    scopus 로고
    • Angiotensinogen polymorphisms and elevated blood pressure in the general population: The Copenhagen Heart Study
    • Sethi, A. A., Nordestgaardt, B. G., Agerholm-Larsen, B., Frandsen, E., Jensen, G. and Tybjaerg-Hansen, A. (2001) Angiotensinogen polymorphisms and elevated blood pressure in the general population: the Copenhagen Heart Study. Hypertension 37, 875-881
    • (2001) Hypertension , vol.37 , pp. 875-881
    • Sethi, A.A.1    Nordestgaardt, B.G.2    Agerholm-Larsen, B.3    Frandsen, E.4    Jensen, G.5    Tybjaerg-Hansen, A.6
  • 90
    • 0030696254 scopus 로고    scopus 로고
    • Association between the angiotensinogen 235T variant and essential hypertension in whites: A systematic review and methodological appraisal
    • Kunz, R., Kreutz, R., Beige, J., Distler, A. and Sharma, A. M. (1997) Association between the angiotensinogen 235T variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension 30, 1331-1337
    • (1997) Hypertension , vol.30 , pp. 1331-1337
    • Kunz, R.1    Kreutz, R.2    Beige, J.3    Distler, A.4    Sharma, A.M.5
  • 91
    • 0038257706 scopus 로고    scopus 로고
    • Angiotensinogen gene and essential hypertension in the Japanese: Extensive association study and meta-analysis on six reported studies
    • Kato, N., Sugiyama, T., Morita, H., Kurihara, H., Yamori, Y. and Yazaki, Y. (1999) Angiotensinogen gene and essential hypertension in the Japanese: extensive association study and meta-analysis on six reported studies. J. Hypertens. 17, 757-763
    • (1999) J. Hypertens , vol.17 , pp. 757-763
    • Kato, N.1    Sugiyama, T.2    Morita, H.3    Kurihara, H.4    Yamori, Y.5    Yazaki, Y.6
  • 92
    • 36949020051 scopus 로고    scopus 로고
    • The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: A possible explanation for heterogeneity in genetic association studies of AGT and hypertension
    • Baker, M., Rahman, T., Hall, D., Avery, P. J., Mayosi, B. M., Connell, J. M., Farrall, M., Watkins, H. and Keavney, B. (2007) The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension. Int. J. Epidemiol. 36, 1356-1362
    • (2007) Int. J. Epidemiol , vol.36 , pp. 1356-1362
    • Baker, M.1    Rahman, T.2    Hall, D.3    Avery, P.J.4    Mayosi, B.M.5    Connell, J.M.6    Farrall, M.7    Watkins, H.8    Keavney, B.9
  • 95
    • 0032979699 scopus 로고    scopus 로고
    • Linkage analysis of candidate genes and gene-gene interactions in Chinese hypertensive sib-pairs
    • Niu, T., Xu, X., Cordell, H. J., Rogus, J., Zhou, Y., Fang, Z. and Lindpainter, K. (1999) Linkage analysis of candidate genes and gene-gene interactions in Chinese hypertensive sib-pairs. Hypertension 33, 1332-1337
    • (1999) Hypertension , vol.33 , pp. 1332-1337
    • Niu, T.1    Xu, X.2    Cordell, H.J.3    Rogus, J.4    Zhou, Y.5    Fang, Z.6    Lindpainter, K.7
  • 96
    • 0031974469 scopus 로고    scopus 로고
    • Niu, T., Xu, X., Rogus, J., Zhou, Y., Chen, C., Yang, Z., Schmitz, C., Zhao, J. and Rao, V. S, (1998) Lindpainter K. Angiotensinogen gene and hypertension in Chinese. J. Clin. Invest. 101, 188-194
    • Niu, T., Xu, X., Rogus, J., Zhou, Y., Chen, C., Yang, Z., Schmitz, C., Zhao, J. and Rao, V. S, (1998) Lindpainter K. Angiotensinogen gene and hypertension in Chinese. J. Clin. Invest. 101, 188-194
  • 98
    • 0033527610 scopus 로고    scopus 로고
    • Exclusion of angiotensinogen gene in molecular basis of human hypertension: Sibpair linkage and association analyses in Australian Anglo-Caucasians
    • Wang, W. Y. S., Glenn, C. L., Zhang, W., Benjafield, A. V., Nyholt, D. R. and Morris, B. J. (1999) Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian Anglo-Caucasians. Am. J. Med. 87, 53-60
    • (1999) Am. J. Med , vol.87 , pp. 53-60
    • Wang, W.Y.S.1    Glenn, C.L.2    Zhang, W.3    Benjafield, A.V.4    Nyholt, D.R.5    Morris, B.J.6
  • 99
    • 0033941303 scopus 로고    scopus 로고
    • Lack of association of the angiotensinogen -6 polymorphism with blood pressure levels in the comprehensive NHLBI Family Blood Pressure Program
    • Province, M. A., Boerwinkle, E., Chakravarti, A., Cooper, R., Fornage, M., Leppert, M., Risch, N. and Ranade, K. (2000) Lack of association of the angiotensinogen -6 polymorphism with blood pressure levels in the comprehensive NHLBI Family Blood Pressure Program. J. Hypertens. 18, 867-876
    • (2000) J. Hypertens , vol.18 , pp. 867-876
    • Province, M.A.1    Boerwinkle, E.2    Chakravarti, A.3    Cooper, R.4    Fornage, M.5    Leppert, M.6    Risch, N.7    Ranade, K.8
  • 100
    • 0034131317 scopus 로고    scopus 로고
    • Lack of association of 3 functional gene variants with hypertension in African Americans
    • Larson, N., Hutchinson, R. and Boerwinkle, E. (2000) Lack of association of 3 functional gene variants with hypertension in African Americans. Hypertension 35, 1297-1300
    • (2000) Hypertension , vol.35 , pp. 1297-1300
    • Larson, N.1    Hutchinson, R.2    Boerwinkle, E.3
  • 101
    • 0037126078 scopus 로고    scopus 로고
    • Angiotensinogen gene promoter region variant modifies body-size-ambulatory blood pressure relations in hypertension
    • Tiago, A. D., Samani, N. J., Candy, G. P., Brooksbank, R., Libhaber, E., Sareli, P., Woodiwiss, A. J. and Norton, G. R. (2002) Angiotensinogen gene promoter region variant modifies body-size-ambulatory blood pressure relations in hypertension. Circulation. 106, 1483-1487
    • (2002) Circulation , vol.106 , pp. 1483-1487
    • Tiago, A.D.1    Samani, N.J.2    Candy, G.P.3    Brooksbank, R.4    Libhaber, E.5    Sareli, P.6    Woodiwiss, A.J.7    Norton, G.R.8
  • 102
  • 104
    • 0142089521 scopus 로고    scopus 로고
    • An association study of angiotensinogen polymorphism with serum level and hypertension in an African American population
    • Wu, X., Luke, A., Rieder, M., Lee, K., Toth, E. J., Nickerson, D., Zhu, X., Kan, D. and Cooper, R. S. (2003) An association study of angiotensinogen polymorphism with serum level and hypertension in an African American population. J. Hypertens. 21, 1847-1852
    • (2003) J. Hypertens , vol.21 , pp. 1847-1852
    • Wu, X.1    Luke, A.2    Rieder, M.3    Lee, K.4    Toth, E.J.5    Nickerson, D.6    Zhu, X.7    Kan, D.8    Cooper, R.S.9
  • 106
    • 3843067473 scopus 로고    scopus 로고
    • Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: Single locus genotype vs haplotype analysis
    • Wu, S. J., Chiang, F. T., Chen, W. J., Liu, P. H., Hus, K. L., Hwang, J. J., Lai, P. P., Lin, J. L., Tseng, C. D. and Tseng, Y. Z. (2004) Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs haplotype analysis. Physiol. Genomics 17, 79-86
    • (2004) Physiol. Genomics , vol.17 , pp. 79-86
    • Wu, S.J.1    Chiang, F.T.2    Chen, W.J.3    Liu, P.H.4    Hus, K.L.5    Hwang, J.J.6    Lai, P.P.7    Lin, J.L.8    Tseng, C.D.9    Tseng, Y.Z.10


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