-
1
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., Puc J., Miliaresis C., Rodgers L., McCombie R., Bigner S.H., Giovanella B.C., Ittmann M., Tycko B., Hibshoosh H., Wigler M.H., and Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275 (1997) 1943-1947
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
2
-
-
51849096491
-
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
-
Knobbe C.B., Lapin V., Suzuki A., and Mak T.W. The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene 27 (2008) 5398-5415
-
(2008)
Oncogene
, vol.27
, pp. 5398-5415
-
-
Knobbe, C.B.1
Lapin, V.2
Suzuki, A.3
Mak, T.W.4
-
3
-
-
51849084360
-
The PTEN-PI3K pathway: of feedbacks and cross-talks
-
Carracedo A., and Pandolfi P.P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 27 (2008) 5527-5541
-
(2008)
Oncogene
, vol.27
, pp. 5527-5541
-
-
Carracedo, A.1
Pandolfi, P.P.2
-
4
-
-
33846493564
-
Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity
-
Wong J.T., Kim P.T., Peacock J.W., Yau T.Y., Mui A.L., Chung S.W., Sossi V., Doudet D., Green D., Ruth T.J., Parsons R., Verchere C.B., and Ong C.J. Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Diabetologia 50 (2007) 395-403
-
(2007)
Diabetologia
, vol.50
, pp. 395-403
-
-
Wong, J.T.1
Kim, P.T.2
Peacock, J.W.3
Yau, T.Y.4
Mui, A.L.5
Chung, S.W.6
Sossi, V.7
Doudet, D.8
Green, D.9
Ruth, T.J.10
Parsons, R.11
Verchere, C.B.12
Ong, C.J.13
-
5
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu P.P., and Sabatini D.M. Cancer cell metabolism: Warburg and beyond. Cell 134 (2008) 703-707
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
6
-
-
11444255268
-
On respiratory impairment in cancer cells
-
Warburg O. On respiratory impairment in cancer cells. Science 124 (1956) 269-270
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
7
-
-
20444487358
-
PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
-
Tang X., Powelka A.M., Soriano N.A., Czech M.P., and Guilherme A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J. Biol. Chem. 280 (2005) 22523-22529
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22523-22529
-
-
Tang, X.1
Powelka, A.M.2
Soriano, N.A.3
Czech, M.P.4
Guilherme, A.5
-
8
-
-
17844371042
-
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes
-
Ono H., Katagiri H., Funaki M., Anai M., Inukai K., Fukushima Y., Sakoda H., Ogihara T., Onishi Y., Fujishiro M., Kikuchi M., Oka Y., and Asano T. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes. Mol. Endocrinol. 15 (2001) 1411-1422
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 1411-1422
-
-
Ono, H.1
Katagiri, H.2
Funaki, M.3
Anai, M.4
Inukai, K.5
Fukushima, Y.6
Sakoda, H.7
Ogihara, T.8
Onishi, Y.9
Fujishiro, M.10
Kikuchi, M.11
Oka, Y.12
Asano, T.13
-
9
-
-
0042971700
-
PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1
-
Radu A., Neubauer V., Akagi T., Hanafusa H., and Georgescu M.M. PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol. Cell Biol. 23 (2003) 6139-6149
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 6139-6149
-
-
Radu, A.1
Neubauer, V.2
Akagi, T.3
Hanafusa, H.4
Georgescu, M.M.5
-
10
-
-
0024503537
-
Estradiol stimulates in vitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106
-
Gray T.K., Mohan S., Linkhart T.A., and Baylink D.J. Estradiol stimulates in vitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106. Biochem. Biophys. Res. Commun. 158 (1992) 407-412
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.158
, pp. 407-412
-
-
Gray, T.K.1
Mohan, S.2
Linkhart, T.A.3
Baylink, D.J.4
-
11
-
-
0024516964
-
A colorimetric assay for the measurement of D-glucose consumption by cultured cells
-
Blake D.A., and McLean N.V. A colorimetric assay for the measurement of D-glucose consumption by cultured cells. Anal. Biochem. 177 (1989) 156-160
-
(1989)
Anal. Biochem.
, vol.177
, pp. 156-160
-
-
Blake, D.A.1
McLean, N.V.2
-
12
-
-
0024551564
-
Rabbit brain glucose transporter responds to insulin when expressed in insulin-sensitive Chinese hamster ovary cells
-
Asano T., Shibasaki Y., Ohno S., Taira H., Lin J.L., Kasuga M., Kanazawa Y., Akanuma Y., Takaku F., and Oka Y. Rabbit brain glucose transporter responds to insulin when expressed in insulin-sensitive Chinese hamster ovary cells. J. Biol. Chem. 264 (1989) 3416-3420
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 3416-3420
-
-
Asano, T.1
Shibasaki, Y.2
Ohno, S.3
Taira, H.4
Lin, J.L.5
Kasuga, M.6
Kanazawa, Y.7
Akanuma, Y.8
Takaku, F.9
Oka, Y.10
-
13
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
Wu M., Neilson A., Swift A.L., Moran R., Tamagnine J., Parslow D., Armistead S., Lemire K., Orrell J., Teich J., Chomicz S., and Ferrick D.A. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am. J. Physiol. Cell Physiol. 292 (2007) C125-C136
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.292
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
Moran, R.4
Tamagnine, J.5
Parslow, D.6
Armistead, S.7
Lemire, K.8
Orrell, J.9
Teich, J.10
Chomicz, S.11
Ferrick, D.A.12
-
14
-
-
33750619348
-
Glucose metabolism and cancer
-
Shaw R.J. Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18 (2006) 598-608
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 598-608
-
-
Shaw, R.J.1
-
15
-
-
37449024702
-
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis R.J., Lum J.J., Hatzivassiliou G., and Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7 (2008) 11-20
-
(2008)
Cell Metab.
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
16
-
-
44449147036
-
Tumor cell metabolism: cancer's Achilles′ heel
-
Kroemer G., and Pouyssegur J. Tumor cell metabolism: cancer's Achilles′ heel. Cancer Cell 13 (2008) 472-482
-
(2008)
Cancer Cell
, vol.13
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
17
-
-
25644446718
-
PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2
-
Levitt R.J., Georgescu M.M., and Pollak M. PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2. Biochem. Biophys. Res. Commun. 336 (2005) 1056-1061
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.336
, pp. 1056-1061
-
-
Levitt, R.J.1
Georgescu, M.M.2
Pollak, M.3
-
18
-
-
33746879141
-
Glycolysis inhibition for anticancer treatment
-
Pelicano H., Martin D.S., Xu R.H., and Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 25 (2006) 4633-4646
-
(2006)
Oncogene
, vol.25
, pp. 4633-4646
-
-
Pelicano, H.1
Martin, D.S.2
Xu, R.H.3
Huang, P.4
-
19
-
-
56749161667
-
2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer
-
Tagg S.L., Foster P.A., Leese M.P., Potter B.V., Reed M.J., Purohit A., and Newman S.P. 2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer. Brit. J. Cancer 99 (2008) 1842-1848
-
(2008)
Brit. J. Cancer
, vol.99
, pp. 1842-1848
-
-
Tagg, S.L.1
Foster, P.A.2
Leese, M.P.3
Potter, B.V.4
Reed, M.J.5
Purohit, A.6
Newman, S.P.7
-
20
-
-
23044456402
-
2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro
-
Zhu Z., Jiang W., McGinley J.N., and Thompson H.J. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 65 (2005) 7023-7030
-
(2005)
Cancer Res.
, vol.65
, pp. 7023-7030
-
-
Zhu, Z.1
Jiang, W.2
McGinley, J.N.3
Thompson, H.J.4
-
21
-
-
57749089652
-
Phosphorylated insulin-like growth factor-1/insulin receptor is present in all breast cancer subtypes and is related to poor survival
-
Law J.H., Habibi G., Hu K., Masoudi H., Wang M.Y.C., Stratford A.L., Park E., Gee J.M.W., Finlay P., Jones H.E., Nicholson R.I., Pollak M., and Dunn S.E. Phosphorylated insulin-like growth factor-1/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res. 68 (2008) 10238-10246
-
(2008)
Cancer Res.
, vol.68
, pp. 10238-10246
-
-
Law, J.H.1
Habibi, G.2
Hu, K.3
Masoudi, H.4
Wang, M.Y.C.5
Stratford, A.L.6
Park, E.7
Gee, J.M.W.8
Finlay, P.9
Jones, H.E.10
Nicholson, R.I.11
Pollak, M.12
Dunn, S.E.13
-
22
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer 8 (2008) 915-928
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
23
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom R.L., Bauer D.E., Buzzai M., Karnauskas R., Harris M.H., Plas D.R., Zhuang H., Cinalli R.M., Alavi A., Rudin C.M., and Thompson C.B. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 64 (2004) 3892-3899
-
(2004)
Cancer Res.
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
24
-
-
84855230675
-
The endocrine pancreas
-
Nussey S.S., and Whitehead S.A. (Eds), Taylor & Francis, London
-
Nussey S.S., and Whitehead S.A. The endocrine pancreas. In: Nussey S.S., and Whitehead S.A. (Eds). Endocrinology: An Integrated Approach (2001), Taylor & Francis, London
-
(2001)
Endocrinology: An Integrated Approach
-
-
Nussey, S.S.1
Whitehead, S.A.2
-
25
-
-
34547838420
-
PTEN, more than the AKT pathway
-
Blanco-Aparicio C., Renner O., Leal J.F., and Carnero A. PTEN, more than the AKT pathway. Carcinogenesis 28 (2007) 1379-1386
-
(2007)
Carcinogenesis
, vol.28
, pp. 1379-1386
-
-
Blanco-Aparicio, C.1
Renner, O.2
Leal, J.F.3
Carnero, A.4
-
26
-
-
0030860466
-
Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis
-
Cheng J.Q., Altomare D.A., Klein M.A., Lee W.C., Kruh G.D., Lissy N.A., and Testa J.R. Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene 14 (1997) 2793-2801
-
(1997)
Oncogene
, vol.14
, pp. 2793-2801
-
-
Cheng, J.Q.1
Altomare, D.A.2
Klein, M.A.3
Lee, W.C.4
Kruh, G.D.5
Lissy, N.A.6
Testa, J.R.7
-
27
-
-
0034671745
-
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-kinase/AKT pathway
-
Gesbert F., Sellers W.R., Signoretti S., Loda M., and Griffin J.D. BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-kinase/AKT pathway. J. Biol. Chem. 275 (2000) 39223-39230
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39223-39230
-
-
Gesbert, F.1
Sellers, W.R.2
Signoretti, S.3
Loda, M.4
Griffin, J.D.5
-
28
-
-
27544450742
-
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation
-
Brandts C.H., Sargin B., Rode M., Biermann C., Lindtner B., Schwable J., Buerger H., Muller-Tidow C., Choudhary C., McMahon M., Berdel W.E., and Serve H. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res. 65 (2005) 9643-9650
-
(2005)
Cancer Res.
, vol.65
, pp. 9643-9650
-
-
Brandts, C.H.1
Sargin, B.2
Rode, M.3
Biermann, C.4
Lindtner, B.5
Schwable, J.6
Buerger, H.7
Muller-Tidow, C.8
Choudhary, C.9
McMahon, M.10
Berdel, W.E.11
Serve, H.12
-
29
-
-
60549111398
-
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
-
Robey R.B., and Hay N. Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin. Cancer Biol. 19 (2009) 25-31
-
(2009)
Semin. Cancer Biol.
, vol.19
, pp. 25-31
-
-
Robey, R.B.1
Hay, N.2
-
30
-
-
61349164207
-
Glucose avidity of carcinomas
-
Ortega A.D., Sanchez-Arago M., Giner-Sanchez D., Sanchez-Cenizo L., Willers I., and Cuezva J.M. Glucose avidity of carcinomas. Cancer Lett. 276 (2009) 125-135
-
(2009)
Cancer Lett.
, vol.276
, pp. 125-135
-
-
Ortega, A.D.1
Sanchez-Arago, M.2
Giner-Sanchez, D.3
Sanchez-Cenizo, L.4
Willers, I.5
Cuezva, J.M.6
-
31
-
-
0037093411
-
Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells
-
Guppy M., Leedman P., Zu X., and Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem. J. 364 (2002) 309-315
-
(2002)
Biochem. J.
, vol.364
, pp. 309-315
-
-
Guppy, M.1
Leedman, P.2
Zu, X.3
Russell, V.4
-
33
-
-
53849118108
-
Metformin attenuates the stimulatory effect of a high energy diet on in vivo H59 carcinoma growth
-
Algire C., Zakikhani M., Blouin M.-J., Shuai J.H., and Pollak M. Metformin attenuates the stimulatory effect of a high energy diet on in vivo H59 carcinoma growth. Endocr. Relat. Cancer 15 (2008) 833-839
-
(2008)
Endocr. Relat. Cancer
, vol.15
, pp. 833-839
-
-
Algire, C.1
Zakikhani, M.2
Blouin, M.-J.3
Shuai, J.H.4
Pollak, M.5
-
34
-
-
38449105596
-
Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts
-
Venkateswaran V., Haddad A.Q., Fleshner N.E., Fan R., Sugar L.M., Nam R., Klotz L.H., and Pollak M. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J. Nat. Cancer Inst. 99 (2007) 1793-1800
-
(2007)
J. Nat. Cancer Inst.
, vol.99
, pp. 1793-1800
-
-
Venkateswaran, V.1
Haddad, A.Q.2
Fleshner, N.E.3
Fan, R.4
Sugar, L.M.5
Nam, R.6
Klotz, L.H.7
Pollak, M.8
-
35
-
-
54349083481
-
Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
-
Ma J., Li H., Giovannucci E., Mucci L., Qiu W., Nguyen P., Gaziano J.M., Pollak M., and Stampfer M. Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol. 9 (2008) 1039-1047
-
(2008)
Lancet Oncol.
, vol.9
, pp. 1039-1047
-
-
Ma, J.1
Li, H.2
Giovannucci, E.3
Mucci, L.4
Qiu, W.5
Nguyen, P.6
Gaziano, J.M.7
Pollak, M.8
Stampfer, M.9
-
36
-
-
11844259994
-
Fasting serum glucose level and cancer risk in Korean men and women
-
Jee S.H., Ohrr H., Sull J.W., Yun J.E., Ji M., and Samet J.M. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293 (2005) 194-202
-
(2005)
JAMA
, vol.293
, pp. 194-202
-
-
Jee, S.H.1
Ohrr, H.2
Sull, J.W.3
Yun, J.E.4
Ji, M.5
Samet, J.M.6
-
37
-
-
0037639715
-
Abnormal glucose tolerance and the risk of cancer death in the United States
-
Saydah S.H., Loria C.M., Eberhardt M.S., and Brancati F.L. Abnormal glucose tolerance and the risk of cancer death in the United States. Am. J. Epidemiol. 157 (2003) 1092-1100
-
(2003)
Am. J. Epidemiol.
, vol.157
, pp. 1092-1100
-
-
Saydah, S.H.1
Loria, C.M.2
Eberhardt, M.S.3
Brancati, F.L.4
-
38
-
-
33847650108
-
Prospective study of hyperglycemia and cancer risk
-
Stattin P., Bjor O., Ferrari P., Lukanova A., Lenner P., Lindahl B., Hallmans G., and Kaaks R. Prospective study of hyperglycemia and cancer risk. Diabetes Care 30 (2007) 561-567
-
(2007)
Diabetes Care
, vol.30
, pp. 561-567
-
-
Stattin, P.1
Bjor, O.2
Ferrari, P.3
Lukanova, A.4
Lenner, P.5
Lindahl, B.6
Hallmans, G.7
Kaaks, R.8
-
39
-
-
58249092146
-
Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
-
Wolpin B.M., Meyerhardt J.A., Chan A.T., Ng K., Chan J.A., Wu K., Pollak M.N., Giovannucci E.L., and Fuchs C.S. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J. Clin. Oncol. 27 (2008) 176-185
-
(2008)
J. Clin. Oncol.
, vol.27
, pp. 176-185
-
-
Wolpin, B.M.1
Meyerhardt, J.A.2
Chan, A.T.3
Ng, K.4
Chan, J.A.5
Wu, K.6
Pollak, M.N.7
Giovannucci, E.L.8
Fuchs, C.S.9
-
40
-
-
20444494440
-
Therapy insight: influence of type 2 diabetes on the development, treatment and outcomes of cancer
-
Richardson L.C., and Pollack L.A. Therapy insight: influence of type 2 diabetes on the development, treatment and outcomes of cancer. Nat. Clin. Pract. Oncol. 2 (2005) 48-53
-
(2005)
Nat. Clin. Pract. Oncol.
, vol.2
, pp. 48-53
-
-
Richardson, L.C.1
Pollack, L.A.2
|